{"id":"https://openalex.org/W2473390472","doi":"https://doi.org/10.1182/blood.v122.21.3621.3621","title":"Dietary Alpha-Linolenic Acid Does Not Protect From Venous Thrombosis In The Vena Cava Stenosis Model","display_name":"Dietary Alpha-Linolenic Acid Does Not Protect From Venous Thrombosis In The Vena Cava Stenosis Model","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2473390472","doi":"https://doi.org/10.1182/blood.v122.21.3621.3621","mag":"2473390472"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.3621.3621","doi":"https://doi.org/10.1182/blood.v122.21.3621.3621","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.3621.3621","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084708009","display_name":"Martin F. Reiner","orcid":"https://orcid.org/0000-0002-9887-2469","observed_orcids":["https://orcid.org/0000-0002-9887-2469"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Martin F Reiner","raw_affiliation_strings":["Cardiovascular Research, Laboratory for Platelet Research, Institute of Physiology, Zurich University, Zurich, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research, Laboratory for Platelet Research, Institute of Physiology, Zurich University, Zurich, Switzerland,","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010854401","display_name":"Simona Stivala","orcid":"https://orcid.org/0000-0003-1549-8932","observed_orcids":["https://orcid.org/0000-0003-1549-8932"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Simona Stivala","raw_affiliation_strings":["Cardiovascular Research, Laboratory for Platelet Research, Institute of Physiology, Zurich University, Zurich, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research, Laboratory for Platelet Research, Institute of Physiology, Zurich University, Zurich, Switzerland,","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085374151","display_name":"Kimberly Martinod","orcid":"https://orcid.org/0000-0002-1026-6107","observed_orcids":["https://orcid.org/0000-0002-1026-6107"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kimberly Martinod","raw_affiliation_strings":["Children\u2019s Hospital, Harvard Medical School, Program in Cellular and Molecular Medicine, Boston, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital, Harvard Medical School, Program in Cellular and Molecular Medicine, Boston, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055832234","display_name":"Giovanni Guido Camici","orcid":"https://orcid.org/0000-0002-0523-0695","observed_orcids":["https://orcid.org/0000-0002-0523-0695"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Giovanni G Camici","raw_affiliation_strings":["Cardiovascular Research, University of Zurich/Institute of Physiology, Zurich, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research, University of Zurich/Institute of Physiology, Zurich, Switzerland,","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113435275","display_name":"Thomas Felix L\u00fcscher","orcid":"https://orcid.org/0000-0002-5259-538X","observed_orcids":["https://orcid.org/0000-0002-5259-538X"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Thomas F L\u00fcscher","raw_affiliation_strings":["Department of Cardiology, University Hospital Zurich, Z\u00fcrich, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, University Hospital Zurich, Z\u00fcrich, Switzerland,","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032584210","display_name":"Denisa D. Wagner","orcid":"https://orcid.org/0000-0002-4494-413X","observed_orcids":["https://orcid.org/0000-0002-4494-413X"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denisa D. Wagner","raw_affiliation_strings":["Department of Pediatrics, Harvard Medical School, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA,","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019077055","display_name":"J\u00fcrg Hans Beer","orcid":"https://orcid.org/0000-0002-7199-0406","observed_orcids":["https://orcid.org/0000-0002-7199-0406"]},"institutions":[{"id":"https://openalex.org/I4210123091","display_name":"Kantonsspital Baden","ror":"https://ror.org/034e48p94","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210123091"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Juerg H. Beer","raw_affiliation_strings":["Internal Medicine, Cantonal Hospital Baden, Baden, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Cantonal Hospital Baden, Baden, Switzerland","institution_ids":["https://openalex.org/I4210123091"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010854401","https://openalex.org/A5055832234","https://openalex.org/A5084708009","https://openalex.org/A5085374151","https://openalex.org/A5113435275"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I202697423","https://openalex.org/I4210100468"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37264985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"21","first_page":"3621","last_page":"3621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-linolenic-acid","display_name":"alpha-linolenic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9010000228881836},{"id":"https://openalex.org/keywords/venous-thrombosis","display_name":"venous thrombosis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pulmonary-embolism","display_name":"pulmonary embolism","score":0.9229999780654907},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/platelet-turnover","display_name":"platelet turnover","score":0.7289999723434448},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.7770000100135803},{"id":"https://openalex.org/keywords/antiplatelet-activity","display_name":"antiplatelet activity","score":0.6320000290870667},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/anticoagulant-activity","display_name":"anticoagulant activity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/thrombus-formation","display_name":"thrombus formation","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8795690536499023},{"id":"https://openalex.org/C2910216633","wikidata":"https://www.wikidata.org/wiki/Q745438","display_name":"Inferior vena cava","level":2,"score":0.7413941621780396},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.7283065319061279},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.7108494639396667},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5424481630325317},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5089766979217529},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.4928126633167267},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.483347624540329},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.47393590211868286},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4392281770706177},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3714984059333801},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3508470058441162},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32485026121139526}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.3621.3621","doi":"https://doi.org/10.1182/blood.v122.21.3621.3621","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.3621.3621","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1996665160","https://openalex.org/W51798655","https://openalex.org/W2170221270","https://openalex.org/W7098846503","https://openalex.org/W2559153866","https://openalex.org/W2981983559","https://openalex.org/W2098516514","https://openalex.org/W2069124360","https://openalex.org/W2239485227","https://openalex.org/W2557067611"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Deep":[2],"vein":[3,187],"thrombosis":[4,58,121,291],"(DVT)":[5],"and":[6,16,32,40,59,72,101,133,177,194,202,221,232,251,338,406,421],"pulmonary":[7],"embolism":[8],"(PE)":[9],"are":[10,23,411],"major":[11],"causes":[12],"of":[13,35,82,87,119,147,216,243,253,289,349,374,394,403,412,417,428,437],"cardiovascular":[14,36],"morbidity":[15],"mortality.":[17],"Omega-3":[18],"fatty":[19],"acids":[20],"(n-3":[21],"FA)":[22],"well":[24],"known":[25],"for":[26,248,257],"their":[27],"beneficial":[28],"effects":[29,81],"on":[30,84],"primary":[31],"secondary":[33],"prevention":[34],"disease":[37],"(CVD).":[38],"We":[39],"others":[41],"have":[42],"previously":[43],"reported":[44],"that":[45,114,354],"n-3":[46],"FA,":[47],"particularly":[48],"the":[49,80,85,90,117,170,184,192,240,254,274,371,392,395,401],"plant-derived":[50],"alpha-linolenic":[51],"acid":[52],"(ALA),":[53],"inhibits":[54],"atherosclerosis,":[55],"reduces":[56],"arterial":[57,384],"decreases":[60],"platelet":[61,99,249,255,329,341,404,423],"activation":[62,100,405],"in":[63,89,95,109,122,188,199,307,328,343,358,370,383,391],"mice":[64,123,143,217,345],"fed":[65],"an":[66,334],"n-3-enriched":[67],"diet":[68],"by":[69,409],"antiinflammatory,":[70],"antiplatelet":[71],"anticoagulant":[73,132],"mechanisms.":[74],"In":[75],"this":[76],"study":[77],"we":[78,112,227,332],"investigated":[79],"ALA":[83,115,269,364,386],"development":[86,118],"DVT":[88,369],"vena":[91,125,164,172,375],"cava":[92,126,165,173,376],"stenosis":[93,127,377],"model":[94,373],"mice.":[96,361],"Hypothesis":[97],"Because":[98],"inflammatory":[102],"processes":[103],"may":[104],"play":[105],"a":[106,178,197,246,339,352],"relevant":[107,435],"role":[108],"venous":[110,120,290,350,397],"thromboembolism,":[111],"hypothesized":[113],"prevents":[116],"undergoing":[124],"due":[128],"to":[129,138,163,183,190,195,264,388,439],"its":[130,380],"antiplatelet,":[131],"antiinflammatory":[134],"properties.":[135],"Methods":[136],"12":[137],"14":[139],"weeks":[140,146],"old":[141],"C57/BL6":[142],"underwent":[144],"4":[145],"high-":[148],"(7.3g%;":[149],"hiALA)":[150],"or":[151],"low-ALA":[152],"(0.03g%;":[153],"loALA)":[154],"treatment":[155,267],"(n=11":[156],"per":[157,284,300,322],"group)":[158],"before":[159],"they":[160],"were":[161,168,208,224],"exposed":[162,176],"stenosis.":[166],"Rodents":[167],"anaesthetized,":[169],"inferior":[171],"(IVC)":[174],"was":[175,180,305,355],"ligature":[179],"placed":[181],"proximal":[182],"left":[185],"renal":[186],"order":[189],"narrow":[191],"IVC":[193],"provoke":[196],"reduction":[198],"blood":[200,229],"flow":[201],"thereby":[203],"induce":[204],"thrombus":[205,219,222],"formation.":[206],"Mice":[207],"examined":[209],"48":[210,347,426],"hours":[211,348],"after":[212,346,425],"initial":[213],"surgery;":[214],"percentage":[215],"with":[218,268],"formation":[220],"length":[223],"determined.":[225],"Additionally,":[226],"performed":[228],"count":[230,337,342,420,424],"analysis":[231],"determined":[233],"plasma":[234],"glycocalicin":[235],"index":[236,304],"(ug/ml/250":[237],"000":[238,313,319],"platelets),":[239],"extramembranous":[241],"portion":[242],"GPIbalpha,":[244],"as":[245],"marker":[247],"turnover":[250],"shedding":[252],"receptor":[256],"von":[258],"Willebrand":[259],"factor":[260],"(vWF).":[261],"Results":[262],"Contrary":[263],"our":[265],"hypothesis,":[266],"did":[270,365],"neither":[271],"significantly":[272],"reduce":[273],"incidence":[275],"(hiALA,":[276,292,310],"55":[277],"%":[278],"vs":[279,295,315],"loALA,":[280,296,316],"64":[281],"%;":[282],"n=11":[283,299],"group,":[285,301,323],"p=ns)":[286],"nor":[287],"size":[288],"2.4":[293],"mm":[294],"2.3":[297],"mm;":[298],"p=ns).":[302],"Glycocalicin":[303],"comparable":[306],"both":[308],"groups":[309],"15.0\u00b18.1":[311],"ug/ml/250":[312,318],"platelets":[314],"11.1\u00b14.5":[317],"platelets;":[320],"n=8":[321],"p=ns),":[324],"indicating":[325],"no":[326],"difference":[327,353],"consumption.":[330],"Interestingly,":[331],"observed":[333,357],"increased":[335,418],"leukocyte":[336,419],"reduced":[340],"hiALA-treated":[344],"thrombosis,":[351,385,398],"not":[356,366],"sham":[359],"operated":[360],"Conclusions":[362],"Dietary":[363],"protect":[367],"from":[368],"mouse":[372],"chosen.":[378],"Despite":[379],"protective":[381],"properties":[382],"seems":[387],"be":[389],"ineffective":[390],"pathogenesis":[393],"stenosis-induced":[396],"possibly":[399],"because":[400],"pathways":[402],"inflammation,":[407],"modified":[408],"ALA,":[410],"lower":[413],"penetrance.":[414],"The":[415],"findings":[416],"decreased":[422],"h":[427],"VT":[429],"warrant":[430],"further":[431],"investigation.":[432],"Disclosures:":[433],"No":[434],"conflicts":[436],"interest":[438],"declare.":[440]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-07-22T00:00:00"}
