{"id":"https://openalex.org/W2473340971","doi":null,"title":"Rapid barrier restitution in an in vitro model of intestinal epithelial injury.","display_name":"Rapid barrier restitution in an in vitro model of intestinal epithelial injury.","publication_year":1989,"publication_date":"1989-02-01","ids":{"openalex":"https://openalex.org/W2473340971","mag":"2473340971","pmid":"https://pubmed.ncbi.nlm.nih.gov/2915518"},"language":"en","primary_location":{"id":"pmid:2915518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2915518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Moore","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110092361","display_name":"Susan Carlson","orcid":"https://orcid.org/0000-0002-4968-7697","observed_orcids":["https://orcid.org/0000-0002-4968-7697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Carlson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077113398","display_name":"Madara Jl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Madara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.0319,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.95543139,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"60","issue":"2","first_page":"237","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.20430000126361847,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.20430000126361847,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.13349999487400055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.13259999454021454,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-epithelial-injury","display_name":"intestinal epithelial damage","score":0.8339999914169312},{"id":"https://openalex.org/keywords/epithelial-repair","display_name":"epithelial repair","score":0.7409999966621399},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.7730000019073486},{"id":"https://openalex.org/keywords/transepithelial-potential-difference","display_name":"transepithelial potential difference","score":0.9909999966621399},{"id":"https://openalex.org/keywords/paracellular-permeability","display_name":"paracellular permeability","score":0.7089999914169312},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.5989999771118164},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.5090000033378601},{"id":"https://openalex.org/keywords/ussing-chamber","display_name":"Ussing chamber","score":0.6769999861717224},{"id":"https://openalex.org/keywords/triton-x-100","display_name":"Triton X-100","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C28938303","wikidata":"https://www.wikidata.org/wiki/Q17122952","display_name":"Transepithelial potential difference","level":4,"score":0.6827836036682129},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.6327744722366333},{"id":"https://openalex.org/C2778445172","wikidata":"https://www.wikidata.org/wiki/Q407646","display_name":"Mannitol","level":2,"score":0.5230494737625122},{"id":"https://openalex.org/C2993711000","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell injury","level":3,"score":0.5080327987670898},{"id":"https://openalex.org/C2779932011","wikidata":"https://www.wikidata.org/wiki/Q581885","display_name":"Ussing chamber","level":3,"score":0.5072411894798279},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48026227951049805},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.4473685622215271},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4185657799243927},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.38541215658187866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3205387592315674},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.2403838038444519},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10715654492378235},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.10298308730125427},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2915518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2915518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:2473340971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2915518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2165505209","https://openalex.org/W2063169895","https://openalex.org/W2415539806","https://openalex.org/W1996912527","https://openalex.org/W383540525","https://openalex.org/W4282006914","https://openalex.org/W2258854732","https://openalex.org/W2059663026","https://openalex.org/W1972958208","https://openalex.org/W2018815492"],"abstract_inverted_index":{"Mild":[0],"forms":[1,266],"of":[2,30,61,67,69,74,127,159,172,186,214,264,267],"intestinal":[3,31,268],"epithelial":[4,18,32,244],"injury":[5,117],"commonly":[6],"occur":[7],"in":[8,27,41,59,246],"many":[9],"disease":[10],"states.":[11],"In":[12,123],"order":[13],"to":[14,50,78,137,163],"study":[15],"how":[16],"such":[17],"\"wounds\"":[19],"heal,":[20],"we":[21],"have":[22],"developed":[23],"a":[24,72,156],"highly":[25],"reproducible":[26],"vitro":[28],"model":[29],"injury.":[33,141,269],"Guinea":[34],"pig":[35],"ileal":[36],"mucosal":[37,46],"sheets":[38],"were":[39,48,148],"mounted":[40],"Ussing":[42],"chambers":[43],"and":[44,94,133,196,230,232],"the":[45,62,65,128,173,184,201,215,220,247,260],"surfaces":[47],"exposed":[49],"0.06%":[51],"Triton-X":[52],"100":[53],"for":[54,92,114,166],"5":[55],"minutes.":[56],"This":[57],"resulted":[58],"denudation":[60,187,216],"epithelium":[63],"at":[64],"tips":[66,147],"86%":[68],"villi.":[70],"As":[71],"result":[73],"this":[75],"injury,":[76,95,145,209],"resistance":[77],"passive":[79],"ion":[80],"flow":[81],"decreased":[82],"significantly":[83],"(56.5":[84],"+/-":[85,89,107,111],"1.3":[86],"versus":[87,109,116],"38.4":[88],"2.3":[90],"ohm.cm2":[91],"control":[93,115,237],"respectively,":[96,118],"p":[97,119],"less":[98,120],"than":[99,121],"0.01),":[100],"as":[101],"did":[102],"transepithelial":[103,125,226],"potential":[104,228],"difference":[105],"(-11.9":[106],"0.7":[108],"-4.3":[110],"0.4":[112],"mV":[113],"0.01).":[122],"parallel,":[124],"fluxes":[126,234],"extracellular":[129],"space":[130],"markers":[131],"mannitol":[132,231],"inulin":[134,233],"increased":[135],"3-":[136],"5-fold":[138],"immediately":[139],"after":[140,144,191,208],"Two":[142],"hours":[143],"villus":[146],"again":[149],"confluently":[150],"covered":[151],"by":[152,167],"columnar":[153],"absorptive":[154,181],"cells,":[155],"time":[157],"course":[158],"healing":[160],"too":[161],"fast":[162],"be":[164,251],"accounted":[165],"enhanced":[168],"cell":[169,198],"proliferation.":[170],"Analysis":[171],"structural":[174,224],"events":[175],"occurring":[176],"during":[177],"recovery":[178],"showed":[179],"that":[180,242],"cells":[182,210],"shouldering":[183],"foci":[185],"rapidly":[188,252],"changed":[189],"shape":[190],"injury:":[192],"they":[193],"became":[194],"flattened":[195],"sent":[197],"projections":[199],"over":[200],"denuded":[202],"basement":[203],"membrane.":[204],"By":[205],"60":[206],"minutes":[207],"from":[211],"opposite":[212],"shoulders":[213],"abutted,":[217],"thus":[218],"resealing":[219],"defect.":[221],"Paralleling":[222],"these":[223],"changes,":[225],"resistance,":[227],"difference,":[229],"returned":[235],"toward":[236],"values.":[238],"These":[239],"data":[240],"show":[241],"focal":[243],"discontinuities":[245],"small":[248],"intestine":[249],"may":[250,257],"resealed.":[253],"Such":[254],"reparative":[255],"processes":[256],"substantially":[258],"limit":[259],"deleterious":[261],"physiologic":[262],"impact":[263],"superficial":[265]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
