{"id":"https://openalex.org/W2473211501","doi":"https://doi.org/10.1080/1028415x.2016.1199114","title":"Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease","display_name":"Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease","publication_year":2016,"publication_date":"2016-06-22","ids":{"openalex":"https://openalex.org/W2473211501","doi":"https://doi.org/10.1080/1028415x.2016.1199114","mag":"2473211501","pmid":"https://pubmed.ncbi.nlm.nih.gov/27329428"},"language":"en","primary_location":{"id":"doi:10.1080/1028415x.2016.1199114","doi":"https://doi.org/10.1080/1028415x.2016.1199114","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1028415x.2016.1199114","pdf_url":null,"source":{"id":"https://openalex.org/S132280141","display_name":"Nutritional Neuroscience","issn_l":"1028-415X","issn":["1028-415X","1476-8305"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutritional Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://eprints.lib.hokudai.ac.jp/repo/huscap/all/67709/WoS_81097_Hata.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044909522","display_name":"Chiori Omori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chiori Omori","raw_affiliation_strings":["Department of Integrated Bioscience, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8562, Japan","Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Bioscience, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8562, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036312661","display_name":"Rika Motodate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rika Motodate","raw_affiliation_strings":["Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039101754","display_name":"Yuzuha Shiraki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuzuha Shiraki","raw_affiliation_strings":["Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069577528","display_name":"Kyoko Chiba","orcid":"https://orcid.org/0000-0001-6919-2782","observed_orcids":["https://orcid.org/0000-0001-6919-2782"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyoko Chiba","raw_affiliation_strings":["Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039317060","display_name":"Yuriko Sobu","orcid":"https://orcid.org/0000-0003-1178-005X","observed_orcids":["https://orcid.org/0000-0003-1178-005X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuriko Sobu","raw_affiliation_strings":["Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102237013","display_name":"Ayano Kimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayano Kimura","raw_affiliation_strings":["Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007583494","display_name":"Tadashi Nakaya","orcid":"https://orcid.org/0000-0002-0743-9062","observed_orcids":["https://orcid.org/0000-0002-0743-9062"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Nakaya","raw_affiliation_strings":["Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000270883","display_name":"Hikaru Kondo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115801","display_name":"SBI Pharmaceuticals (Japan)","ror":"https://ror.org/028mhrr87","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115801"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hikaru Kondo","raw_affiliation_strings":["SBI Pharmaceuticals Co., Ltd, Tokyo 106-6020, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SBI Pharmaceuticals Co., Ltd, Tokyo 106-6020, Japan","institution_ids":["https://openalex.org/I4210115801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066866446","display_name":"Satoshi Kurumiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115801","display_name":"SBI Pharmaceuticals (Japan)","ror":"https://ror.org/028mhrr87","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115801"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Kurumiya","raw_affiliation_strings":["SBI Pharmaceuticals Co., Ltd, Tokyo 106-6020, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SBI Pharmaceuticals Co., Ltd, Tokyo 106-6020, Japan","institution_ids":["https://openalex.org/I4210115801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101471439","display_name":"Toru Tanaka","orcid":"https://orcid.org/0000-0002-1054-9211","observed_orcids":["https://orcid.org/0000-0002-1054-9211"]},"institutions":[{"id":"https://openalex.org/I4210115801","display_name":"SBI Pharmaceuticals (Japan)","ror":"https://ror.org/028mhrr87","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115801"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Tanaka","raw_affiliation_strings":["SBI Pharmaceuticals Co., Ltd, Tokyo 106-6020, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SBI Pharmaceuticals Co., Ltd, Tokyo 106-6020, Japan","institution_ids":["https://openalex.org/I4210115801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086388019","display_name":"Kazuo Yamamoto","orcid":"https://orcid.org/0000-0001-7466-2443","observed_orcids":["https://orcid.org/0000-0001-7466-2443"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Yamamoto","raw_affiliation_strings":["Department of Integrated Bioscience, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8562, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Bioscience, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8562, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021593247","display_name":"Motowo Nakajima","orcid":"https://orcid.org/0000-0001-7687-6365","observed_orcids":["https://orcid.org/0000-0001-7687-6365"]},"institutions":[{"id":"https://openalex.org/I4210115801","display_name":"SBI Pharmaceuticals (Japan)","ror":"https://ror.org/028mhrr87","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115801"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motowo Nakajima","raw_affiliation_strings":["SBI Pharmaceuticals Co., Ltd, Tokyo 106-6020, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SBI Pharmaceuticals Co., Ltd, Tokyo 106-6020, Japan","institution_ids":["https://openalex.org/I4210115801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065167441","display_name":"Toshiharu Suzuki","orcid":"https://orcid.org/0000-0002-1655-2374","observed_orcids":["https://orcid.org/0000-0002-1655-2374"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiharu Suzuki","raw_affiliation_strings":["Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102983829","display_name":"Saori Hata","orcid":"https://orcid.org/0000-0003-4723-5993","observed_orcids":["https://orcid.org/0000-0003-4723-5993"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Saori Hata","raw_affiliation_strings":["Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102983829"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":null,"apc_paid":null,"fwci":0.7176,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.61906937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"20","issue":"9","first_page":"538","last_page":"546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.08209999650716782,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.7710000276565552},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8690000176429749},{"id":"https://openalex.org/keywords/synaptotagmin","display_name":"synaptotagmin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7839999794960022},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7320502400398254},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.7293699979782104},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.5757361650466919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5547595024108887},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.49485868215560913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47839486598968506},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44068339467048645},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.43609923124313354},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.4360799789428711},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4133034944534302},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39255490899086},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38265880942344666},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3551631271839142},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3423963189125061},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.31637609004974365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23227769136428833},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07927143573760986}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050857","descriptor_name":"Synaptotagmins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/1028415x.2016.1199114","doi":"https://doi.org/10.1080/1028415x.2016.1199114","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1028415x.2016.1199114","pdf_url":null,"source":{"id":"https://openalex.org/S132280141","display_name":"Nutritional Neuroscience","issn_l":"1028-415X","issn":["1028-415X","1476-8305"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutritional Neuroscience","raw_type":"journal-article"},{"id":"pmid:27329428","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27329428","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutritional neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01364:0007182962","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2115/67709","pdf_url":"https://eprints.lib.hokudai.ac.jp/repo/huscap/all/67709/WoS_81097_Hata.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutritional neuroscience","raw_type":"journal article"},{"id":"pmh:oai:eprints.lib.hokudai.ac.jp:2115/67709","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2115/67709","pdf_url":null,"source":{"id":"https://openalex.org/S4306400549","display_name":"Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205349734","host_organization_name":"Hokkaido University","host_organization_lineage":["https://openalex.org/I205349734"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article (author version)"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01364:0007182962","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2115/67709","pdf_url":"https://eprints.lib.hokudai.ac.jp/repo/huscap/all/67709/WoS_81097_Hata.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutritional neuroscience","raw_type":"journal article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4890741302","display_name":"Alzheimer's disease-related peptides as a biomarker for diagnosis in early stage Alzheimer's disease","funder_award_id":"15K18854","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G537454738","display_name":"\u30ad\u30cd\u30b7\u30f3\u8efd\u9396\uff08\uff2b\uff2c\uff23\uff09\u30ea\u30f3\u9178\u5316\u306b\u3088\u308b\uff21\uff30\uff30\u8ef8\u7d22\u8f38\u9001\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e","funder_award_id":"15J02220","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5769272341","display_name":"\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u65b0\u898f\u8840\u6db2\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u78ba\u7acb","funder_award_id":"17J06504","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2473211501.pdf","grobid_xml":"https://content.openalex.org/works/W2473211501.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W39375236","https://openalex.org/W1529447899","https://openalex.org/W1967464880","https://openalex.org/W1968900405","https://openalex.org/W1973276273","https://openalex.org/W1984222168","https://openalex.org/W1992285081","https://openalex.org/W1996656968","https://openalex.org/W2006909664","https://openalex.org/W2007136766","https://openalex.org/W2016750393","https://openalex.org/W2022852477","https://openalex.org/W2037321375","https://openalex.org/W2038013184","https://openalex.org/W2040953865","https://openalex.org/W2043773978","https://openalex.org/W2044329567","https://openalex.org/W2052309340","https://openalex.org/W2061656250","https://openalex.org/W2072453593","https://openalex.org/W2075080704","https://openalex.org/W2075604126","https://openalex.org/W2080124845","https://openalex.org/W2080225612","https://openalex.org/W2089670732","https://openalex.org/W2109352508","https://openalex.org/W2112299930","https://openalex.org/W2118479885","https://openalex.org/W2129787742","https://openalex.org/W2135220503","https://openalex.org/W2147386004","https://openalex.org/W2150771555","https://openalex.org/W2171776741","https://openalex.org/W2290293100","https://openalex.org/W2321151839","https://openalex.org/W2336745021"],"related_works":["https://openalex.org/W3023420624","https://openalex.org/W2890363323","https://openalex.org/W2980786560","https://openalex.org/W2124432028","https://openalex.org/W2036661299","https://openalex.org/W2105442740","https://openalex.org/W1968877051","https://openalex.org/W2155460466","https://openalex.org/W7008723358","https://openalex.org/W255435190"],"abstract_inverted_index":{"The":[0],"activities":[1,185],"of":[2,22,108,126,145,169,179,189,197],"mitochondrial":[3,37,83,118,183],"enzymes,":[4],"which":[5],"are":[6],"essential":[7,47],"for":[8,101],"neural":[9,198],"function,":[10],"decline":[11],"with":[12,31,60,78],"age":[13],"and":[14,112,166],"in":[15,29,49,64,72,85,124,130,139,154,163,186],"age-related":[16],"disease.":[17],"In":[18],"particular,":[19],"the":[20,50,69,86,187,195],"activity":[21,84,111],"cytochrome":[23],"c":[24],"oxidase":[25],"(COX/complex":[26],"IV)":[27],"decreases":[28],"patients":[30],"Alzheimer's":[32],"disease":[33],"(AD).":[34],"COX,":[35],"a":[36,91],"inner":[38],"membrane":[39,119],"protein":[40,113,133],"complex":[41],"that":[42,54,76,175],"contains":[43],"heme,":[44],"plays":[45],"an":[46],"role":[48],"electron":[51],"transport":[52],"chain":[53],"generates":[55],"ATP.":[56],"Heme":[57],"synthesis":[58],"begins":[59],"5-aminolevulinic":[61],"acid":[62],"(5-ALA)":[63],"mitochondria.":[65],"5-ALA":[66,79,94,180],"synthetase":[67],"is":[68],"rate-limiting":[70],"enzyme":[71,184],"heme":[73],"synthesis,":[74],"suggesting":[75,142],"supplementation":[77],"might":[80],"help":[81],"preserve":[82,182],"aged":[87,190],"brain.":[88],"We":[89],"administered":[90],"diet":[92],"containing":[93],"to":[95,152,194],"triple-transgenic":[96],"AD":[97],"(3xTg-AD)":[98],"model":[99],"mice":[100,128],"6":[102],"months,":[103],"starting":[104],"at":[105],"3":[106],"months":[107],"age.":[109],"COX":[110],"expression,":[114],"as":[115,117],"well":[116],"potential,":[120],"were":[121,135],"significantly":[122,137],"higher":[123,138],"brains":[125,188],"5-ALA-fed":[127,140,155],"than":[129],"controls.":[131],"Synaptotagmin":[132],"levels":[134,150],"also":[136],"mice,":[141,156],"improved":[143],"preservation":[144,196],"synapses.":[146],"Although":[147],"brain":[148],"A\u03b2":[149],"tended":[151],"decrease":[153],"we":[157],"observed":[158],"no":[159],"other":[160,164],"significant":[161],"changes":[162],"biochemical":[165],"pathological":[167],"hallmarks":[168],"AD.":[170],"Nevertheless,":[171],"our":[172],"study":[173],"suggests":[174],"daily":[176],"oral":[177],"administration":[178],"could":[181],"individuals,":[191],"thereby":[192],"contributing":[193],"activity.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}