{"id":"https://openalex.org/W2472482880","doi":"https://doi.org/10.1016/j.ygcen.2016.06.007","title":"Ancient origins of metazoan gonadotropin-releasing hormone and their receptors revealed by phylogenomic analyses","display_name":"Ancient origins of metazoan gonadotropin-releasing hormone and their receptors revealed by phylogenomic analyses","publication_year":2016,"publication_date":"2016-06-27","ids":{"openalex":"https://openalex.org/W2472482880","doi":"https://doi.org/10.1016/j.ygcen.2016.06.007","mag":"2472482880","pmid":"https://pubmed.ncbi.nlm.nih.gov/27318276"},"language":"en","primary_location":{"id":"doi:10.1016/j.ygcen.2016.06.007","doi":"https://doi.org/10.1016/j.ygcen.2016.06.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ygcen.2016.06.007","pdf_url":null,"source":{"id":"https://openalex.org/S12418545","display_name":"General and Comparative Endocrinology","issn_l":"0016-6480","issn":["0016-6480","1095-6840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General and Comparative Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.sciencedirect.com/science/article/pii/S0016648016301654","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038350329","display_name":"David C. Plachetzki","orcid":"https://orcid.org/0000-0002-6255-7117","observed_orcids":["https://orcid.org/0000-0002-6255-7117","https://orcid.org/0000-0002-3629-5862"]},"institutions":[{"id":"https://openalex.org/I161057412","display_name":"University of New Hampshire","ror":"https://ror.org/01rmh9n78","country_code":"US","type":"education","lineage":["https://openalex.org/I161057412"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David C. Plachetzki","raw_affiliation_strings":["Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA. Electronic address: david.plachetzki@unh.edu","Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA. Electronic address: david.plachetzki@unh.edu","institution_ids":["https://openalex.org/I161057412"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA","institution_ids":["https://openalex.org/I161057412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063039957","display_name":"Pei\u2010San Tsai","orcid":"https://orcid.org/0000-0002-8650-647X","observed_orcids":["https://orcid.org/0000-0002-8650-647X"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pei-San Tsai","raw_affiliation_strings":["Department of Integrative Physiology, University of Colorado, Boulder, CO 80301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Physiology, University of Colorado, Boulder, CO 80301, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056327955","display_name":"Scott I. Kavanaugh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott I. Kavanaugh","raw_affiliation_strings":["Department of Integrative Physiology, University of Colorado, Boulder, CO 80301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Physiology, University of Colorado, Boulder, CO 80301, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109251635","display_name":"Stacia A. Sower","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161057412","display_name":"University of New Hampshire","ror":"https://ror.org/01rmh9n78","country_code":"US","type":"education","lineage":["https://openalex.org/I161057412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacia A. Sower","raw_affiliation_strings":["Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA","institution_ids":["https://openalex.org/I161057412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038350329"],"corresponding_institution_ids":["https://openalex.org/I161057412"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":5.6275,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.95383539,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"234","issue":null,"first_page":"10","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":1.0},{"id":"https://openalex.org/keywords/gnrh-receptor","display_name":"GnRH receptor","score":0.9750000238418579},{"id":"https://openalex.org/keywords/animal-evolution","display_name":"animal evolution","score":0.7580000162124634},{"id":"https://openalex.org/keywords/phylogenomics","display_name":"phylogenomics","score":0.7929999828338623},{"id":"https://openalex.org/keywords/gene-family-evolution","display_name":"gene family evolution","score":0.6169999837875366},{"id":"https://openalex.org/keywords/functional-diversification","display_name":"functional diversification","score":0.7080000042915344},{"id":"https://openalex.org/keywords/complete-genome-sequence","display_name":"complete genome sequence","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9066246747970581},{"id":"https://openalex.org/C70343354","wikidata":"https://www.wikidata.org/wiki/Q3381973","display_name":"Phylogenomics","level":5,"score":0.7988977432250977},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.6619021892547607},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.6494272947311401},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.621185302734375},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5774970054626465},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4942324459552765},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48044058680534363},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47421884536743164},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.4395908713340759},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40973734855651855},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3222537040710449},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2780829071998596},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1538301408290863},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.07281801104545593},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ygcen.2016.06.007","doi":"https://doi.org/10.1016/j.ygcen.2016.06.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ygcen.2016.06.007","pdf_url":null,"source":{"id":"https://openalex.org/S12418545","display_name":"General and Comparative Endocrinology","issn_l":"0016-6480","issn":["0016-6480","1095-6840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General and Comparative Endocrinology","raw_type":"journal-article"},{"id":"pmid:27318276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27318276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General and comparative endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:scholars.unh.edu:nhaes-1394","doi":null,"is_oa":true,"landing_page_url":"http://www.sciencedirect.com/science/article/pii/S0016648016301654","pdf_url":null,"source":{"id":"https://openalex.org/S4377196362","display_name":"University of New Hampshire Scholars Repository (University of New Hampshire at Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179093154","host_organization_name":"University of New Hampshire at Manchester","host_organization_lineage":["https://openalex.org/I179093154"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"New Hampshire Agricultural Experiment Station Publications","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:scholars.unh.edu:nhaes-1394","doi":null,"is_oa":true,"landing_page_url":"http://www.sciencedirect.com/science/article/pii/S0016648016301654","pdf_url":null,"source":{"id":"https://openalex.org/S4377196362","display_name":"University of New Hampshire Scholars Repository (University of New Hampshire at Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179093154","host_organization_name":"University of New Hampshire at Manchester","host_organization_lineage":["https://openalex.org/I179093154"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"New Hampshire Agricultural Experiment Station Publications","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W114860795","https://openalex.org/W340499956","https://openalex.org/W1519799765","https://openalex.org/W1535234579","https://openalex.org/W1970120281","https://openalex.org/W1973146503","https://openalex.org/W1977872165","https://openalex.org/W1979680271","https://openalex.org/W1982202404","https://openalex.org/W1988283772","https://openalex.org/W1996890142","https://openalex.org/W2004746698","https://openalex.org/W2006506216","https://openalex.org/W2010099444","https://openalex.org/W2010156002","https://openalex.org/W2011815428","https://openalex.org/W2015390387","https://openalex.org/W2017362191","https://openalex.org/W2018991353","https://openalex.org/W2020168144","https://openalex.org/W2021035293","https://openalex.org/W2030480841","https://openalex.org/W2031493923","https://openalex.org/W2032513215","https://openalex.org/W2041612616","https://openalex.org/W2047267343","https://openalex.org/W2058803523","https://openalex.org/W2067558229","https://openalex.org/W2070443686","https://openalex.org/W2090189198","https://openalex.org/W2090707309","https://openalex.org/W2095575977","https://openalex.org/W2108434344","https://openalex.org/W2112813788","https://openalex.org/W2115888213","https://openalex.org/W2124484137","https://openalex.org/W2129714767","https://openalex.org/W2130653478","https://openalex.org/W2141052558","https://openalex.org/W2141582604","https://openalex.org/W2158714788","https://openalex.org/W2160378127","https://openalex.org/W2164026798","https://openalex.org/W2170747616","https://openalex.org/W2171336109","https://openalex.org/W2176014258"],"related_works":["https://openalex.org/W2058803523","https://openalex.org/W2015390387","https://openalex.org/W2081962689","https://openalex.org/W2090189198","https://openalex.org/W7101096871","https://openalex.org/W2112813788","https://openalex.org/W2084013566","https://openalex.org/W7100864616","https://openalex.org/W2133147677","https://openalex.org/W2386277062"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-07-22T00:00:00"}