{"id":"https://openalex.org/W2472467404","doi":"https://doi.org/10.1212/wnl.0000000000002975","title":"Should the symptomatic region be included in dissemination in space in MRI criteria for MS?","display_name":"Should the symptomatic region be included in dissemination in space in MRI criteria for MS?","publication_year":2016,"publication_date":"2016-07-16","ids":{"openalex":"https://openalex.org/W2472467404","doi":"https://doi.org/10.1212/wnl.0000000000002975","mag":"2472467404","pmid":"https://pubmed.ncbi.nlm.nih.gov/27421541","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4999167"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000002975","doi":"https://doi.org/10.1212/wnl.0000000000002975","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000002975","pdf_url":"https://n.neurology.org/content/neurology/87/7/680.full.pdf","source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://n.neurology.org/content/neurology/87/7/680.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069134946","display_name":"Wallace J. Brownlee","orcid":"https://orcid.org/0000-0003-0481-8902","observed_orcids":["https://orcid.org/0000-0003-0481-8902"]},"institutions":[{"id":"https://openalex.org/I4210138523","display_name":"UCL Biomedical Research Centre","ror":"https://ror.org/03r9qc142","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I124357947","https://openalex.org/I1340918713","https://openalex.org/I34931013","https://openalex.org/I4210138523","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wallace J. Brownlee","raw_affiliation_strings":["From the Queen Square Multiple Sclerosis Centre (W.J.B., J.K.S., D.H.M., O.C.), Department of Neuroinflammation, UCL Institute of Neurology, London; Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London; and NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London","NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Queen Square Multiple Sclerosis Centre (W.J.B., J.K.S., D.H.M., O.C.), Department of Neuroinflammation, UCL Institute of Neurology, London; Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London; and NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","institution_ids":["https://openalex.org/I4210138523","https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London","institution_ids":["https://openalex.org/I4210151618"]},{"raw_affiliation_string":"NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","institution_ids":["https://openalex.org/I4210138523","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113480505","display_name":"Josephine K. Swanton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138523","display_name":"UCL Biomedical Research Centre","ror":"https://ror.org/03r9qc142","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I124357947","https://openalex.org/I1340918713","https://openalex.org/I34931013","https://openalex.org/I4210138523","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Josephine K. Swanton","raw_affiliation_strings":["From the Queen Square Multiple Sclerosis Centre (W.J.B., J.K.S., D.H.M., O.C.), Department of Neuroinflammation, UCL Institute of Neurology, London; Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London; and NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London","NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Queen Square Multiple Sclerosis Centre (W.J.B., J.K.S., D.H.M., O.C.), Department of Neuroinflammation, UCL Institute of Neurology, London; Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London; and NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","institution_ids":["https://openalex.org/I4210138523","https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London","institution_ids":["https://openalex.org/I4210151618"]},{"raw_affiliation_string":"NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","institution_ids":["https://openalex.org/I4210138523","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112212209","display_name":"Katherine Miszkiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138523","display_name":"UCL Biomedical Research Centre","ror":"https://ror.org/03r9qc142","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I124357947","https://openalex.org/I1340918713","https://openalex.org/I34931013","https://openalex.org/I4210138523","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katherine A. Miszkiel","raw_affiliation_strings":["From the Queen Square Multiple Sclerosis Centre (W.J.B., J.K.S., D.H.M., O.C.), Department of Neuroinflammation, UCL Institute of Neurology, London; Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London; and NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London","NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Queen Square Multiple Sclerosis Centre (W.J.B., J.K.S., D.H.M., O.C.), Department of Neuroinflammation, UCL Institute of Neurology, London; Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London; and NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","institution_ids":["https://openalex.org/I4210138523","https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London","institution_ids":["https://openalex.org/I4210151618"]},{"raw_affiliation_string":"NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","institution_ids":["https://openalex.org/I4210138523","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103380063","display_name":"David H. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138523","display_name":"UCL Biomedical Research Centre","ror":"https://ror.org/03r9qc142","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I124357947","https://openalex.org/I1340918713","https://openalex.org/I34931013","https://openalex.org/I4210138523","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David H. Miller","raw_affiliation_strings":["From the Queen Square Multiple Sclerosis Centre (W.J.B., J.K.S., D.H.M., O.C.), Department of Neuroinflammation, UCL Institute of Neurology, London; Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London; and NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London","NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Queen Square Multiple Sclerosis Centre (W.J.B., J.K.S., D.H.M., O.C.), Department of Neuroinflammation, UCL Institute of Neurology, London; Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London; and NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","institution_ids":["https://openalex.org/I4210138523","https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London","institution_ids":["https://openalex.org/I4210151618"]},{"raw_affiliation_string":"NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","institution_ids":["https://openalex.org/I4210138523","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067383775","display_name":"Olga Ciccarelli","orcid":"https://orcid.org/0000-0001-7485-1367","observed_orcids":["https://orcid.org/0000-0001-7485-1367","https://orcid.org/0000-0003-0638-1660"]},"institutions":[{"id":"https://openalex.org/I4210138523","display_name":"UCL Biomedical Research Centre","ror":"https://ror.org/03r9qc142","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I124357947","https://openalex.org/I1340918713","https://openalex.org/I34931013","https://openalex.org/I4210138523","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Olga Ciccarelli","raw_affiliation_strings":["From the Queen Square Multiple Sclerosis Centre (W.J.B., J.K.S., D.H.M., O.C.), Department of Neuroinflammation, UCL Institute of Neurology, London; Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London; and NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London","NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Queen Square Multiple Sclerosis Centre (W.J.B., J.K.S., D.H.M., O.C.), Department of Neuroinflammation, UCL Institute of Neurology, London; Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London; and NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","institution_ids":["https://openalex.org/I4210138523","https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Lysholm Department of Neuroradiology (K.A.M.), National Hospital for Neurology and Neurosurgery, London","institution_ids":["https://openalex.org/I4210151618"]},{"raw_affiliation_string":"NIHR University College London Hospitals Biomedical Research Centre (D.H.M., O.C.), London, UK","institution_ids":["https://openalex.org/I4210138523","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.641,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.97466497,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"87","issue":"7","first_page":"680","last_page":"683"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12574","display_name":"Clinical Reasoning and Diagnostic Skills","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dissemination-in-space","display_name":"dissemination in space","score":0.7620000243186951},{"id":"https://openalex.org/keywords/clinically-isolated-syndrome","display_name":"clinically isolated syndrome","score":0.9100000262260437},{"id":"https://openalex.org/keywords/multiple-sclerosis-diagnosis","display_name":"multiple sclerosis diagnosis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/asymptomatic-lesions","display_name":"asymptomatic lesions","score":0.753000020980835},{"id":"https://openalex.org/keywords/mcdonald-criteria","display_name":"McDonald criteria","score":0.5529999732971191},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.4569999873638153},{"id":"https://openalex.org/keywords/spinal-cord-syndromes","display_name":"spinal cord syndromes","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8336880207061768},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8037519454956055},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7862011194229126},{"id":"https://openalex.org/C2781028063","wikidata":"https://www.wikidata.org/wiki/Q338802","display_name":"Clinically isolated syndrome","level":3,"score":0.6332272887229919},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5546139478683472},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4979555606842041},{"id":"https://openalex.org/C187382586","wikidata":"https://www.wikidata.org/wiki/Q1208166","display_name":"McDonald criteria","level":3,"score":0.480898380279541},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4427463710308075},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24862700700759888},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24292629957199097},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1212/wnl.0000000000002975","doi":"https://doi.org/10.1212/wnl.0000000000002975","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000002975","pdf_url":"https://n.neurology.org/content/neurology/87/7/680.full.pdf","source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:27421541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27421541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4999167","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4999167/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10057966","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10057966/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroIogy , 87 (7) pp. 680-683. (2016)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1212/wnl.0000000000002975","doi":"https://doi.org/10.1212/wnl.0000000000002975","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000002975","pdf_url":"https://n.neurology.org/content/neurology/87/7/680.full.pdf","source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G661966807","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0508-10058","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2472467404.pdf","grobid_xml":"https://content.openalex.org/works/W2472467404.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1943838624","https://openalex.org/W2020947088","https://openalex.org/W2105026328","https://openalex.org/W2122545833","https://openalex.org/W2127304332","https://openalex.org/W2130355701","https://openalex.org/W2132444350","https://openalex.org/W2135900660","https://openalex.org/W2142577589","https://openalex.org/W2144361404","https://openalex.org/W2280334572","https://openalex.org/W2916040650"],"related_works":["https://openalex.org/W4401115208","https://openalex.org/W2890810701","https://openalex.org/W2510596572","https://openalex.org/W2479795811","https://openalex.org/W2020947088","https://openalex.org/W2400091534","https://openalex.org/W2105026328","https://openalex.org/W3111998338","https://openalex.org/W2776062928","https://openalex.org/W7098194822"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"investigate":[2],"whether":[3],"inclusion":[4,94,107],"of":[5,14,23,57,66,95,108,119,133,143,199,216,245,260],"lesions":[6,78,97,164,189,238],"in":[7,16,29,79,98,102,111,115,165,179,185,190,194,239,272],"the":[8,12,55,64,71,80,93,99,106,112,120,126,131,144,154,166,180,191,197,217,240,246,254,258,265],"symptomatic":[9,81,100,113,167,181,192,241],"region":[10,101,114,168,182,193,242],"influences":[11],"performance":[13,118],"dissemination":[15],"space":[17],"(DIS)":[18],"criteria":[19,75,124,129,146,201,219,247],"for":[20,63,130,153,202,220,233,248,256],"a":[21,32],"diagnosis":[22],"clinically":[24,33],"definite":[25],"multiple":[26,204,221],"sclerosis":[27,205],"(CDMS)":[28],"patients":[30,41,234],"with":[31,42,44,235],"isolated":[34],"syndrome":[35],"(CIS).":[36],"METHODS:":[37],"We":[38,68],"studied":[39],"30":[40],"CIS":[43,58],"brainstem/cerebellar":[45],"and":[46,59,87,104,125,141,151,160,171,174],"spinal":[47],"cord":[48],"syndromes":[49],"who":[50],"had":[51],"MRI":[52,85,200],"scans":[53,86],"at":[54],"time":[56],"were":[60,169],"followed":[61],"up":[62],"development":[65,132,259],"CDMS.":[67,261],"retrospectively":[69],"applied":[70],"McDonald":[72,121,155],"2010":[73,122,156],"DIS":[74,90,123,145,195,249],"(excluding":[76],"all":[77],"region)":[82],"to":[83,267],"baseline":[84],"2":[88,127],"modified":[89,128],"criteria:":[91],"(1)":[92],"asymptomatic":[96,163],"DIS,":[103],"(2)":[105],"any":[109,177],"lesion":[110,178],"DIS.":[116,186],"The":[117,138,262],"CDMS":[134],"was":[135,183],"compared.":[136],"RESULTS:":[137],"sensitivity,":[139],"specificity,":[140],"accuracy":[142,255],"was,":[147],"respectively,":[148],"73%,":[149,150,159,173],"73%":[152],"criteria,":[157],"80%,":[158],"77%":[161],"when":[162,176],"included,":[170],"87%,":[172],"80%":[175],"included":[184],"CONCLUSIONS:":[187],"Including":[188],"increases":[196],"sensitivity":[198],"diagnosing":[203],"without":[206],"compromising":[207],"specificity.":[208],"These":[209],"findings":[210],"may":[211],"help":[212],"inform":[213],"future":[214],"revisions":[215],"diagnostic":[218],"sclerosis.":[222],"CLASSIFICATION":[223],"OF":[224],"EVIDENCE:":[225],"This":[226],"study":[227,263],"provides":[228],"Class":[229],"II":[230],"evidence":[231],"that":[232],"CIS,":[236],"including":[237],"as":[243],"part":[244],"does":[250],"not":[251],"significantly":[252],"increase":[253],"predicting":[257],"lacks":[264],"precision":[266],"detect":[268],"an":[269],"important":[270],"change":[271],"accuracy.":[273]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-07-22T00:00:00"}
