{"id":"https://openalex.org/W2472314652","doi":null,"title":"Effects of Microgravity on the Phenotype, Genome and Transcriptome ofStreptococcus pneumonia","display_name":"Effects of Microgravity on the Phenotype, Genome and Transcriptome ofStreptococcus pneumonia","publication_year":2016,"publication_date":"2016-07-07","ids":{"openalex":"https://openalex.org/W2472314652","mag":"2472314652"},"language":"en","primary_location":{"id":"mag:2472314652","doi":null,"is_oa":false,"landing_page_url":"https://www.rroij.com/open-access/effects-of-microgravity-on-the-phenotype-genome-and-transcriptome-ofstreptococcus-pneumonia-.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764950498","display_name":"Research and Reviews: Journal of Microbiology and Biotechnology","issn_l":"2320-3528","issn":["2320-3528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Research and Reviews: Journal of Microbiology and Biotechnology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101816720","display_name":"Jia Li","orcid":"https://orcid.org/0000-0002-5931-3058","observed_orcids":["https://orcid.org/0000-0002-5931-3058","https://orcid.org/0009-0009-8688-9878","https://orcid.org/0009-0005-1471-210X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5931-3058","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023714026","display_name":"Yinghua Guo","orcid":"https://orcid.org/0009-0008-1724-3603","observed_orcids":["https://orcid.org/0009-0008-1724-3603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yinghua Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-1724-3603","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009598980","display_name":"Guogang Xu","orcid":"https://orcid.org/0000-0002-6380-3500","observed_orcids":["https://orcid.org/0000-0002-6380-3500"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guogang Xu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6380-3500","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029444910","display_name":"Xuelin Zhang","orcid":"https://orcid.org/0000-0002-2466-5600","observed_orcids":["https://orcid.org/0000-0002-2466-5600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuelin Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2466-5600","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057396658","display_name":"Lei Pan","orcid":"https://orcid.org/0000-0001-5713-7583","observed_orcids":["https://orcid.org/0000-0001-5713-7583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Pan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5713-7583","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101471935","display_name":"Hong Zhong","orcid":"https://orcid.org/0000-0002-5387-775X","observed_orcids":["https://orcid.org/0000-0002-5387-775X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018724814","display_name":"Chou Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chou Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101881410","display_name":"Changting Liu","orcid":"https://orcid.org/0000-0002-3849-8508","observed_orcids":["https://orcid.org/0000-0002-3849-8508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Changting Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3849-8508","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1983,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.76084746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"5","issue":"2","first_page":"107","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":1.0},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7480000257492065},{"id":"https://openalex.org/keywords/bacterial-phenotypes","display_name":"bacterial phenotypes","score":0.5590000152587891},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.847000002861023},{"id":"https://openalex.org/keywords/bacterial-metabolism","display_name":"bacterial metabolism","score":0.5519999861717224},{"id":"https://openalex.org/keywords/space-microbiology","display_name":"space microbiology","score":0.7509999871253967},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.7179999947547913},{"id":"https://openalex.org/keywords/genome","display_name":"genome","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7808098793029785},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.7320539951324463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.685479998588562},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.6429075002670288},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6208544373512268},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5869480967521667},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5171379446983337},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4418604373931885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3582000136375427},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3415314555168152},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2881792485713959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2369418740272522},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2472314652","doi":null,"is_oa":false,"landing_page_url":"https://www.rroij.com/open-access/effects-of-microgravity-on-the-phenotype-genome-and-transcriptome-ofstreptococcus-pneumonia-.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764950498","display_name":"Research and Reviews: Journal of Microbiology and Biotechnology","issn_l":"2320-3528","issn":["2320-3528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Research and Reviews: Journal of Microbiology and Biotechnology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1589619032","https://openalex.org/W1929308123","https://openalex.org/W1964326294","https://openalex.org/W1965936382","https://openalex.org/W1969761972","https://openalex.org/W1999224755","https://openalex.org/W2002975202","https://openalex.org/W2004812025","https://openalex.org/W2008274231","https://openalex.org/W2055043387","https://openalex.org/W2065626701","https://openalex.org/W2067813501","https://openalex.org/W2068069512","https://openalex.org/W2075147307","https://openalex.org/W2097012953","https://openalex.org/W2097341408","https://openalex.org/W2103366497","https://openalex.org/W2115380923","https://openalex.org/W2123507289","https://openalex.org/W2129933858","https://openalex.org/W2131738221","https://openalex.org/W2139532252","https://openalex.org/W2142808585","https://openalex.org/W2154431984","https://openalex.org/W2280445196","https://openalex.org/W2291848994","https://openalex.org/W2413284878","https://openalex.org/W3021225149"],"related_works":["https://openalex.org/W1997798901","https://openalex.org/W4412052466","https://openalex.org/W2230980915","https://openalex.org/W7098181595","https://openalex.org/W4394767087","https://openalex.org/W7220362361","https://openalex.org/W4313897291","https://openalex.org/W2003853068","https://openalex.org/W2267386744","https://openalex.org/W3145397376"],"abstract_inverted_index":{"Objective:":[0],"Microgravity":[1],"can":[2],"influence":[3,146],"pathogenic":[4],"bacteria":[5],"by":[6],"changing":[7],"their":[8],"various":[9,46],"biological":[10],"characteristics.":[11],"However,":[12],"how":[13],"microgravity":[14,38,89,96,122,142],"affects":[15],"Streptococcus":[16,31,153],"pneumoniae":[17,32],"as":[18,20],"well":[19],"the":[21,77,80,88,95,109,121,152,165],"relevant":[22],"mechanisms":[23],"remain":[24],"unclear.":[25],"Methods:":[26],"A":[27,64],"multiple":[28,168],"drug":[29],"resistant":[30],"strain":[33,90,97,123],"was":[34,70],"cultured":[35],"in":[36,126,151],"a":[37,144],"or":[39],"gravity":[40,75],"environment":[41],"for":[42,53],"16":[43],"h.":[44],"Subsequently,":[45],"phenotypic":[47],"assays":[48],"were":[49],"performed,":[50],"including":[51],"those":[52],"morphology,":[54,81],"growth":[55,82],"curves,":[56],"biofilm":[57,85],"formation":[58,86],"and":[59,61,67,76,84,104,107,116,134,149,159,171],"acid":[60,103],"base":[62,105],"stress.":[63],"combined":[65],"genomic":[66,115],"transcriptomic":[68,117],"analysis":[69],"performed.":[71],"Results:":[72],"Compared":[73],"with":[74],"parental":[78],"strain,":[79],"curve":[83],"of":[87,167,179],"did":[91],"not":[92],"change,":[93],"whereas":[94],"had":[98,124],"increased":[99],"resistance":[100],"to":[101,111,130,161],"weak":[102],"solutions":[106],"lost":[108],"ability":[110],"utilize":[112],"glucuronamide.":[113],"Comparative":[114],"analyses":[118],"revealed":[119],"that":[120],"changes":[125],"gene":[127],"expression":[128],"related":[129],"metabolism,":[131],"cell":[132,135],"wall/capsule":[133],"defense":[136],"mechanisms.":[137],"Conclusion:":[138],"Our":[139],"study":[140],"reveals":[141],"has":[143],"significant":[145],"on":[147],"metabolism":[148],"adaptation":[150],"pneumoniae,":[154],"which":[155],"exhibit":[156],"great":[157],"flexibility":[158],"adaptability":[160],"survive":[162],"successfully":[163],"via":[164],"regulation":[166],"physiological":[169],"functions":[170],"cellular":[172],"pathways.":[173],"It":[174],"may":[175],"provide":[176],"new":[177],"understanding":[178],"space":[180],"microbiology.":[181]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}