{"id":"https://openalex.org/W2472294178","doi":null,"title":"InherIted cancer syndromes should be cons I dered I n young pat I ents w I th newly d I agnosed head and neck cancer","display_name":"InherIted cancer syndromes should be cons I dered I n young pat I ents w I th newly d I agnosed head and neck cancer","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2472294178","mag":"2472294178"},"language":"en","primary_location":{"id":"mag:2472294178","doi":null,"is_oa":false,"landing_page_url":"https://www.rcpe.ac.uk/sites/default/files/letters_7.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031102865","display_name":"R. J. Casasola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"R. J. Casasola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031102865"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.08540000021457672,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0706000030040741,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fanconi-anemia","display_name":"Fanconi anemia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hereditary-cancer-syndromes","display_name":"hereditary cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/young-patients","display_name":"young patients","score":0.9309999942779541},{"id":"https://openalex.org/keywords/delayed-diagnosis","display_name":"delayed diagnosis","score":0.5080000162124634},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.6359999775886536},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mucositis","display_name":"mucositis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.8840000033378601},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8921002745628357},{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.759743332862854},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7526916861534119},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6800943613052368},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.6274914741516113},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.43710488080978394},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42727071046829224},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4160788953304291},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32819628715515137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29936379194259644},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2472294178","doi":null,"is_oa":false,"landing_page_url":"https://www.rcpe.ac.uk/sites/default/files/letters_7.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1966231504","https://openalex.org/W1969322965","https://openalex.org/W1985627639"],"related_works":["https://openalex.org/W2399260867","https://openalex.org/W4408160299","https://openalex.org/W2577060780","https://openalex.org/W4213098324","https://openalex.org/W4293558878","https://openalex.org/W3031885030","https://openalex.org/W2091698428","https://openalex.org/W2169029426","https://openalex.org/W3213285445","https://openalex.org/W4250854585"],"abstract_inverted_index":{"The":[0,32],"recognition":[1],"of":[2,8,35,93,105,125,129,168],"those":[3],"inherited":[4,19],"cancer":[5,20,47,111,119,133,172],"syndromes,":[6],"especially":[7],"FA,":[9],"is":[10,39,56,69,82,138,160,181,185],"important":[11,163],"for":[12,54,61,84],"the":[13,91,122],"following":[14],"reasons.":[15],"Typically,":[16],"patients":[17,106,142],"with":[18,23,107,109,178],"syndromes":[21],"present":[22],"head":[24,65,130],"and":[25,42,66,79,117,131,149,157],"neck":[26,67,118,132],"cancers":[27,68],"at":[28],"a":[29,96,166],"young":[30],"age.":[31],"median":[33],"age":[34,53],"classical":[36],"FA":[37,44,80,94,108,114,141,169],"diagnosis":[38,45,48,81,88,92,112,167],"seven":[40],"years":[41,51],"usually":[43],"precedes":[46,90,113],"by":[49,95,175],"several":[50,85],"(median":[52],"leukaemia":[55],"16":[57],"years,":[58],"whereas":[59],"that":[60,102],"solid":[62],"tumors":[63],"including":[64],"26":[70],"years).":[71],"Occasionally,":[72],"they":[73],"do":[74],"not":[75],"have":[76],"characteristic":[77],"features":[78],"delayed":[83],"years.":[86,98],"Cancer":[87],"often":[89],"few":[97],"One":[99],"study":[100],"shows":[101],"in":[103,134],"25%":[104],"cancers,":[110],"diagnosis.":[115],"Head":[116],"may":[120,189],"be":[121,190],"initial":[123],"presentation":[124],"FA.":[126],"3":[127],"Management":[128,174],"this":[135],"patient":[136],"population":[137],"different":[139],"as":[140],"are":[143],"extremely":[144],"sensitive":[145],"to":[146,154,164],"both":[147],"chemotherapy":[148],"radiotherapy,":[150],"which":[151],"can":[152],"lead":[153],"severe":[155],"myelosuppression":[156],"mucositis.":[158],"It":[159],"therefore":[161],"very":[162],"establish":[165],"before":[170],"initiating":[171],"treatment.":[173],"surgical":[176],"resection":[177],"clear":[179],"margins":[180],"preferred.":[182],"If":[183],"surgery":[184],"contraindicated,":[186],"dose-adjusted":[187],"radiotherapy":[188],"employed.":[191],"4":[192],"Attempts":[193]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-07-22T00:00:00"}
