{"id":"https://openalex.org/W2472201763","doi":"https://doi.org/10.1152/ajpcell.1989.257.2.c306","title":"Excess membrane cholesterol alters calcium channels in arterial smooth muscle","display_name":"Excess membrane cholesterol alters calcium channels in arterial smooth muscle","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W2472201763","doi":"https://doi.org/10.1152/ajpcell.1989.257.2.c306","mag":"2472201763","pmid":"https://pubmed.ncbi.nlm.nih.gov/2548388"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1989.257.2.c306","doi":"https://doi.org/10.1152/ajpcell.1989.257.2.c306","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1989.257.2.c306","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069211636","display_name":"Russell Bialecki","orcid":"https://orcid.org/0000-0002-6215-1440","observed_orcids":["https://orcid.org/0000-0002-6215-1440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. A. Bialecki","raw_affiliation_strings":["Department of Physiology and Biochemistry, Medical College of Pennsylvania, Philadelphia 19129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biochemistry, Medical College of Pennsylvania, Philadelphia 19129","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056933276","display_name":"Thomas N. Tulenko","orcid":"https://orcid.org/0000-0002-7802-418X","observed_orcids":["https://orcid.org/0000-0002-7802-418X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. N. Tulenko","raw_affiliation_strings":["Department of Physiology and Biochemistry, Medical College of Pennsylvania, Philadelphia 19129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biochemistry, Medical College of Pennsylvania, Philadelphia 19129","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2416,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.89809831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"257","issue":"2","first_page":"C306","last_page":"C314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.4413999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.4413999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.3091000020503998,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.1200999990105629,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-cholesterol","display_name":"membrane cholesterol","score":0.9089999794960022},{"id":"https://openalex.org/keywords/calcium-channels","display_name":"calcium channels","score":0.6449999809265137},{"id":"https://openalex.org/keywords/arterial-smooth-muscle","display_name":"arterial smooth muscle","score":0.9599999785423279},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.6150000095367432},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.7689999938011169},{"id":"https://openalex.org/keywords/diltiazem","display_name":"diltiazem","score":0.8700000047683716},{"id":"https://openalex.org/keywords/carotid-artery","display_name":"carotid artery","score":0.9179999828338623},{"id":"https://openalex.org/keywords/free-cholesterol","display_name":"free cholesterol","score":0.7599999904632568},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.6940000057220459},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6784268021583557},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6470212936401367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5717425346374512},{"id":"https://openalex.org/C2776741139","wikidata":"https://www.wikidata.org/wiki/Q422229","display_name":"Diltiazem","level":3,"score":0.5414867401123047},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5288965106010437},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.48918846249580383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4725736677646637},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.4544232189655304},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.4516035318374634},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4038049280643463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3398445248603821},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3290863335132599},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2641468048095703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1356014609336853},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.12394708395004272},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.1989.257.2.c306","doi":"https://doi.org/10.1152/ajpcell.1989.257.2.c306","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1989.257.2.c306","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:2548388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2548388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1543005995","display_name":null,"funder_award_id":"HL 07443","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G154661298","display_name":null,"funder_award_id":"HL-30497","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G691361488","display_name":null,"funder_award_id":"AG-04908","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1586357743","https://openalex.org/W1775749144","https://openalex.org/W1907558192","https://openalex.org/W1931373251","https://openalex.org/W1949328632","https://openalex.org/W1965587893","https://openalex.org/W1984012424","https://openalex.org/W1989058572","https://openalex.org/W1989491652","https://openalex.org/W1999113230","https://openalex.org/W2006403346","https://openalex.org/W2009475191","https://openalex.org/W2023217871","https://openalex.org/W2024456751","https://openalex.org/W2046625142","https://openalex.org/W2060155280","https://openalex.org/W2063687527","https://openalex.org/W2090354171","https://openalex.org/W2149747420","https://openalex.org/W2152311269","https://openalex.org/W2184373622","https://openalex.org/W2326373073"],"related_works":["https://openalex.org/W2416419305","https://openalex.org/W2020543835","https://openalex.org/W2054728789","https://openalex.org/W2037417906","https://openalex.org/W3142888289","https://openalex.org/W4400192519","https://openalex.org/W2063687527","https://openalex.org/W2415723342","https://openalex.org/W2169335826","https://openalex.org/W282720191"],"abstract_inverted_index":{"We":[0,91],"studied":[1],"the":[2,21,25,64,118,150,199],"effects":[3,13,66],"of":[4,24,40,67,124,195],"cholesterol":[5,32,43,122,177],"enrichment":[6,123,128],"on":[7,14,165],"arterial":[8,203],"function":[9],"by":[10,183],"evaluating":[11],"its":[12],"45Ca2+":[15,94,159],"uptake":[16,81,95,160,167],"and":[17,45,78,82,89,98],"tension":[18],"development":[19],"in":[20,33,48,117,153,168,198,202],"carotid":[22],"artery":[23],"rabbit.":[26],"Arterial":[27],"segments":[28,54],"were":[29,55,73],"enriched":[30],"with":[31,58,102,113,145],"vitro,":[34],"using":[35],"media":[36],"containing":[37],"liposomes":[38],"composed":[39],"free":[41],"(unesterified)":[42],"(FC)":[44],"phospholipid":[46],"(PL)":[47],"a":[49,114,193],"2:1":[50],"molar":[51],"ratio.":[52],"Control":[53],"simultaneously":[56],"perfused":[57],"0.5:1":[59],"liposomal":[60],"medium":[61],"to":[62,86,108,142],"compare":[63],"possible":[65],"PL.":[68],"Rings":[69],"from":[70],"these":[71],"arteries":[72],"then":[74],"tested":[75],"for":[76,83],"basal":[77,97,154,185],"activated":[79],"Ca2+":[80,137,188],"contractile":[84,105,140,181],"responses":[85],"norepinephrine":[87],"(NE)":[88],"KCl.":[90],"found":[92],"elevated":[93],"under":[96],"NE-activated":[99,158,187],"conditions":[100],"along":[101],"an":[103],"increased":[104],"sensitivity":[106,141,182],"(4-fold)":[107],"NE.":[109],"These":[110,171],"alterations":[111],"correlated":[112],"78%":[115],"increase":[116,152],"FC/PL":[119],"ratio":[120],"reflecting":[121],"cellular":[125],"membranes.":[126],"Cholesterol":[127],"did":[129],"not":[130],"alter":[131],"resting":[132],"or":[133,139,186],"maximal":[134],"tensions,":[135],"K+-activated":[136],"uptake,":[138],"K+.":[143],"Pretreatment":[144],"1":[146],"microM":[147],"diltiazem":[148],"abolished":[149],"cholesterol-induced":[151],"as":[155,157,192],"well":[156],"but":[161],"had":[162],"no":[163],"effect":[164],"either":[166],"control":[169],"vessels.":[170],"studies":[172],"suggest":[173],"that":[174],"excess":[175],"membrane":[176],"selectively":[178],"increases":[179],"NE":[180],"increasing":[184],"influx":[189],"(or":[190],"both)":[191],"result":[194],"fundamental":[196],"alteration":[197],"calcium":[200],"channels":[201],"smooth":[204],"muscle":[205],"cell":[206],"membrane.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}