{"id":"https://openalex.org/W2472108572","doi":"https://doi.org/10.1021/jacs.6b03463","title":"HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective","display_name":"HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective","publication_year":2016,"publication_date":"2016-07-05","ids":{"openalex":"https://openalex.org/W2472108572","doi":"https://doi.org/10.1021/jacs.6b03463","mag":"2472108572","pmid":"https://pubmed.ncbi.nlm.nih.gov/27379525","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5063305"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.6b03463","doi":"https://doi.org/10.1021/jacs.6b03463","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.6b03463","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5063305","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087828355","display_name":"Qian Chu","orcid":"https://orcid.org/0000-0001-6550-6975","observed_orcids":["https://orcid.org/0000-0001-6550-6975"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Chu","raw_affiliation_strings":["Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030590878","display_name":"Jolene K. Diedrich","orcid":"https://orcid.org/0000-0001-6489-4558","observed_orcids":["https://orcid.org/0000-0001-6489-4558"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jolene K. Diedrich","raw_affiliation_strings":["Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States","Department\rof Chemical Physiology, The Scripps Research Institute, 10550 North\rTorrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Department\rof Chemical Physiology, The Scripps Research Institute, 10550 North\rTorrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110087639","display_name":"Joan M. Vaughan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan M. Vaughan","raw_affiliation_strings":["Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055776264","display_name":"Cynthia J. Donaldson","orcid":"https://orcid.org/0000-0001-9731-7765","observed_orcids":["https://orcid.org/0000-0001-9731-7765"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia J. Donaldson","raw_affiliation_strings":["Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031389133","display_name":"Michael F. Nunn","orcid":"https://orcid.org/0000-0002-6771-9912","observed_orcids":["https://orcid.org/0000-0002-6771-9912"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael F. Nunn","raw_affiliation_strings":["Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042285286","display_name":"Kuo\u2010Fen Lee","orcid":"https://orcid.org/0000-0003-2224-2708","observed_orcids":["https://orcid.org/0000-0003-2224-2708"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuo-Fen Lee","raw_affiliation_strings":["Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065981856","display_name":"Alan Saghatelian","orcid":"https://orcid.org/0000-0002-0427-563X","observed_orcids":["https://orcid.org/0000-0002-0427-563X"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan Saghatelian","raw_affiliation_strings":["Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clayton\rFoundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065981856"],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.1088,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.93839315,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"138","issue":"30","first_page":"9473","last_page":"9478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htra1","display_name":"HTRA1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9279999732971191},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8560000061988831},{"id":"https://openalex.org/keywords/apoe3","display_name":"APOE3","score":0.9240000247955322},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8629999756813049},{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.871999979019165},{"id":"https://openalex.org/keywords/htra2","display_name":"HtrA2","score":0.8579999804496765},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.906000018119812},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.45899999141693115},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9683396816253662},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.8668729662895203},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6538742780685425},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.6059190630912781},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.46737661957740784},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31323695182800293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24074983596801758},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10031569004058838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.058394938707351685},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.043529123067855835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000074289","descriptor_name":"High-Temperature Requirement A Serine Peptidase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000074289","descriptor_name":"High-Temperature Requirement A Serine Peptidase 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/jacs.6b03463","doi":"https://doi.org/10.1021/jacs.6b03463","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.6b03463","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:27379525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27379525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5063305","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5063305","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5063305","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5063305","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1467663617","display_name":"Optogenetic dissection of brain network deficits in Alzheimer's Disease","funder_award_id":"RF1AG047669","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1568627883","display_name":"Exploring Human-Induced Pluripotent Stem Cells for Alzheimer's Disease Research","funder_award_id":"RF1AG042985","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G198914242","display_name":null,"funder_award_id":"#2012-PG-MED002","funder_id":"https://openalex.org/F4320309446","funder_display_name":"Leona M. and Harry B. Helmsley Charitable Trust"},{"id":"https://openalex.org/G2471163508","display_name":null,"funder_award_id":"AG0476669","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2953307044","display_name":"Physiology and function of basal ganglia subcircuits in sequence learning","funder_award_id":"R01NS083815","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G43644990","display_name":null,"funder_award_id":"AG042985","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8772364824","display_name":null,"funder_award_id":"CA014195 MASS","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000880274","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014195","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306264","display_name":"Joe W. and Dorothy Dorsett Brown Foundation","ror":"https://ror.org/043291659"},{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320312259","display_name":"Albert G. and Olive H. Schlink Foundation","ror":"https://ror.org/00aq1tf09"},{"id":"https://openalex.org/F4320317374","display_name":"George E. Hewitt Foundation for Medical Research","ror":"https://ror.org/00frbfx46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1498746132","https://openalex.org/W1586314603","https://openalex.org/W1827206204","https://openalex.org/W1964802599","https://openalex.org/W1968900405","https://openalex.org/W1976357608","https://openalex.org/W2004262276","https://openalex.org/W2007929153","https://openalex.org/W2012034410","https://openalex.org/W2017404389","https://openalex.org/W2022276045","https://openalex.org/W2030723550","https://openalex.org/W2036362108","https://openalex.org/W2061916198","https://openalex.org/W2064179601","https://openalex.org/W2066918975","https://openalex.org/W2067064610","https://openalex.org/W2069121057","https://openalex.org/W2075489369","https://openalex.org/W2079888227","https://openalex.org/W2082011949","https://openalex.org/W2082429191","https://openalex.org/W2086266092","https://openalex.org/W2090688839","https://openalex.org/W2096410114","https://openalex.org/W2099040516","https://openalex.org/W2100006021","https://openalex.org/W2100885315","https://openalex.org/W2112727874","https://openalex.org/W2113059497","https://openalex.org/W2115738813","https://openalex.org/W2121101037","https://openalex.org/W2129085204","https://openalex.org/W2140718540","https://openalex.org/W2146249493","https://openalex.org/W2146670116","https://openalex.org/W2164635944","https://openalex.org/W2166714905","https://openalex.org/W2185034389","https://openalex.org/W7074228914"],"related_works":["https://openalex.org/W4408051451","https://openalex.org/W7161796436","https://openalex.org/W4416066693","https://openalex.org/W2093032849","https://openalex.org/W2021255192","https://openalex.org/W2560287996","https://openalex.org/W7132068834","https://openalex.org/W4220869344","https://openalex.org/W2113059497","https://openalex.org/W425302475"],"abstract_inverted_index":{"Apolipoprotein":[0],"E":[1],"(ApoE)":[2],"belongs":[3],"to":[4,59,75,84,128,153,165],"a":[5,85,201],"large":[6],"class":[7],"of":[8,55,169,192,209],"proteins":[9,211],"that":[10,80,110,117,184,205],"solubilize":[11],"lipids":[12],"for":[13,40,48],"physiological":[14],"transport.":[15],"Humans":[16],"have":[17],"three":[18],"different":[19],"APOE":[20,22,24,27],"alleles,":[21],"\u03b52,":[23],"\u03b53,":[25],"and":[26,29,71,139,146,159,181],"\u03b54,":[28],"genetic":[30,37],"studies":[31],"identified":[32],"ApoE4":[33,49,72,81,119,137,145,185,193,207],"as":[34,130,194,213],"the":[35,78,91,106,155,160,167,190],"strongest":[36],"risk":[38],"factor":[39],"Alzheimer's":[41],"disease":[42],"(AD).":[43],"People":[44],"who":[45],"are":[46,52],"homozygous":[47],"(i.e.,":[50],"ApoE4/E4)":[51],"an":[53,113,195],"order":[54],"magnitude":[56],"more":[57,120],"likely":[58],"develop":[60],"late-onset":[61],"AD":[62,76,210],"(LOAD)":[63],"than":[64,88,122],"ApoE3/E3":[65],"carriers.":[66],"Several":[67],"differences":[68],"between":[69,144],"ApoE3":[70,89],"may":[73],"contribute":[74],"including":[77],"observation":[79],"is":[82,103,112,126],"degraded":[83],"greater":[86],"extent":[87],"in":[90,105,196],"human":[92],"brain.":[93],"Experiments":[94],"with":[95,133,174,178],"high-temperature":[96],"requirement":[97],"serine":[98],"peptidase":[99],"A1":[100],"(HtrA1),":[101],"which":[102],"found":[104],"nervous":[107],"system,":[108],"demonstrate":[109],"HtrA1":[111,148,198],"allele-selective":[114],"ApoE-degrading":[115],"enzyme":[116],"degrades":[118],"quickly":[121],"ApoE3.":[123,147],"This":[124],"activity":[125],"specific":[127],"HtrA1,":[129],"similar":[131],"assays":[132,177],"HtrA2":[134],"showed":[135],"minimal":[136],"proteolysis":[138],"trypsin":[140],"had":[141],"no":[142],"preference":[143],"has":[149],"also":[150],"been":[151],"reported":[152],"cleave":[154],"tau":[156],"protein":[157,162],"(Tau)":[158],"amyloid":[161,171],"precursor":[163],"(APP)":[164],"hinder":[166],"formation":[168],"toxic":[170],"deposits":[172],"associated":[173],"AD.":[175],"Competition":[176],"ApoE4,":[179],"ApoE3,":[180],"Tau":[182,187],"revealed":[183],"inhibits":[186],"degradation.":[188],"Thus,":[189],"identification":[191],"vitro":[197],"substrate":[199],"suggests":[200],"potential":[202],"biochemical":[203],"mechanism":[204],"links":[206],"regulation":[208],"such":[212],"Tau.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
