{"id":"https://openalex.org/W2471997040","doi":"https://doi.org/10.1016/s0022-5347(17)35944-x","title":"In vitro Sensitivity Testing of Human Bladder Cancers and Cell Lines to TP-40, a Hybrid Protein with selective Targeting and Cytotoxicity","display_name":"In vitro Sensitivity Testing of Human Bladder Cancers and Cell Lines to TP-40, a Hybrid Protein with selective Targeting and Cytotoxicity","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W2471997040","doi":"https://doi.org/10.1016/s0022-5347(17)35944-x","mag":"2471997040","pmid":"https://pubmed.ncbi.nlm.nih.gov/8230543"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)35944-x","doi":"https://doi.org/10.1016/s0022-5347(17)35944-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)35944-x","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111883646","display_name":"Michael F. Sarosdy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael F. Sarosdy","raw_affiliation_strings":["From the Divisions of Urology and Oncology, University of Texas Health Science Center, San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Divisions of Urology and Oncology, University of Texas Health Science Center, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036589366","display_name":"Denise H. Hutzler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise H. Hutzler","raw_affiliation_strings":["From the Divisions of Urology and Oncology, University of Texas Health Science Center, San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Divisions of Urology and Oncology, University of Texas Health Science Center, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033966004","display_name":"Douglas Yee","orcid":"https://orcid.org/0000-0002-3387-4009","observed_orcids":["https://orcid.org/0000-0002-3387-4009"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Yee","raw_affiliation_strings":["From the Divisions of Urology and Oncology, University of Texas Health Science Center, San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Divisions of Urology and Oncology, University of Texas Health Science Center, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080900202","display_name":"Daniel D. Von Hoff","orcid":"https://orcid.org/0000-0003-4723-7681","observed_orcids":["https://orcid.org/0000-0003-4723-7681"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel D. Von Hoff","raw_affiliation_strings":["From the Divisions of Urology and Oncology, University of Texas Health Science Center, San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Divisions of Urology and Oncology, University of Texas Health Science Center, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.7419,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.72194886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"150","issue":"6","first_page":"1950","last_page":"1955"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.859000027179718},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.8320000171661377},{"id":"https://openalex.org/keywords/intravesical-therapy","display_name":"intravesical therapy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/targeted-cytotoxicity","display_name":"targeted cytotoxicity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/clonogenic-assay","display_name":"clonogenic assay","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8825749158859253},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7761474251747131},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6156957149505615},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5278016328811646},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4750123918056488},{"id":"https://openalex.org/C2992454250","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Human bladder","level":4,"score":0.44689470529556274},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.43717339634895325},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3691953420639038},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.33161312341690063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2126026749610901},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13735881447792053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12078291177749634},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000097668","descriptor_name":"Pseudomonas aeruginosa Exotoxin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000922","descriptor_name":"Immunotoxins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(17)35944-x","doi":"https://doi.org/10.1016/s0022-5347(17)35944-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)35944-x","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:8230543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8230543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W26171313","https://openalex.org/W109080602","https://openalex.org/W191777685","https://openalex.org/W1513717105","https://openalex.org/W1820859680","https://openalex.org/W1871697173","https://openalex.org/W1984766041","https://openalex.org/W1991915284","https://openalex.org/W2016453061","https://openalex.org/W2067572281","https://openalex.org/W2091850352","https://openalex.org/W2134812217","https://openalex.org/W2140858291","https://openalex.org/W2162145488","https://openalex.org/W2333193688","https://openalex.org/W2406128874","https://openalex.org/W2414380551","https://openalex.org/W2415345353","https://openalex.org/W2418144139","https://openalex.org/W2926514374","https://openalex.org/W6648350475"],"related_works":["https://openalex.org/W2115782579","https://openalex.org/W2396255352","https://openalex.org/W4252147254","https://openalex.org/W2472003768","https://openalex.org/W1984766041","https://openalex.org/W3185741131","https://openalex.org/W2124745809","https://openalex.org/W7099409339","https://openalex.org/W2560096903","https://openalex.org/W2086493291"],"abstract_inverted_index":{"TP-40":[0,45,71,98],"is":[1],"a":[2,13,47],"hybrid":[3],"fusion":[4],"protein":[5],"produced":[6],"by":[7,75],"recombinant":[8],"technology":[9],"and":[10,30],"consists":[11],"of":[12,15,28,124],"molecule":[14],"transforming":[16],"growth":[17,56],"factor-alpha":[18],"(TGF-alpha)":[19],"fused":[20],"to":[21,38,44,70,77,92,101,114],"the":[22,65,122],"Pseudomonas":[23],"exotoxin":[24],"PE-40.":[25],"A":[26],"panel":[27],"human":[29,80,125],"murine":[31],"bladder":[32,81,109,126],"cancer":[33,110],"cell":[34],"lines":[35,51],"was":[36],"found":[37],"be":[39,73,102],"universally":[40],"sensitive":[41,89],"in":[42,46,90,108],"vitro":[43,91],"clonogenic":[48],"assay.":[49],"All":[50],"expressed":[52],"receptor":[53],"for":[54,64],"epidermal":[55],"factor":[57],"(EGF),":[58],"though":[59],"none":[60],"demonstrated":[61],"gene":[62],"amplification":[63],"EGF":[66,118],"receptor.":[67],"The":[68],"sensitivity":[69],"may":[72,99],"blocked":[74],"preexposure":[76],"EGF.":[78],"Six":[79],"tumors":[82],"taken":[83],"directly":[84],"from":[85],"patients":[86],"were":[87],"all":[88],"TP-40;":[93],"these":[94],"included":[95],"well-differentiated":[96],"tumors.":[97],"prove":[100],"effective":[103],"as":[104,120],"an":[105],"intravesical":[106],"agent":[107],"via":[111],"selective":[112],"targeting":[113],"cells":[115],"that":[116],"express":[117],"receptors,":[119],"do":[121],"majority":[123],"cancers.":[127]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
