{"id":"https://openalex.org/W2471978271","doi":"https://doi.org/10.1101/gad.282145.116","title":"RB1 : a prototype tumor suppressor and an enigma","display_name":"RB1 : a prototype tumor suppressor and an enigma","publication_year":2016,"publication_date":"2016-07-01","ids":{"openalex":"https://openalex.org/W2471978271","doi":"https://doi.org/10.1101/gad.282145.116","mag":"2471978271","pmid":"https://pubmed.ncbi.nlm.nih.gov/27401552","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4949322"},"language":"en","primary_location":{"id":"doi:10.1101/gad.282145.116","doi":"https://doi.org/10.1101/gad.282145.116","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.282145.116","pdf_url":null,"source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2471978271"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1101/gad.282145.116","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054890414","display_name":"Nicholas J. Dyson","orcid":"https://orcid.org/0000-0001-8119-5513","observed_orcids":["https://orcid.org/0000-0001-8119-5513"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicholas J. Dyson","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054890414"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":458,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"13","first_page":"1492","last_page":"1502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rb1","display_name":"RB1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9509999752044678},{"id":"https://openalex.org/keywords/retinoblastoma","display_name":"retinoblastoma","score":0.9269999861717224},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/rb1-mutation","display_name":"RB1 mutation","score":0.593999981880188},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8368661403656006},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.7739715576171875},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.7540029883384705},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.6547062993049622},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.6476149559020996},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5829545855522156},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5110210180282593},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4652683734893799},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.44683602452278137},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.44306379556655884},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4307805299758911},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.40895822644233704},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.20967885851860046},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050684","descriptor_name":"E2F Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056286","descriptor_name":"Retinoblastoma Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056286","descriptor_name":"Retinoblastoma Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1101/gad.282145.116","doi":"https://doi.org/10.1101/gad.282145.116","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.282145.116","pdf_url":null,"source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4949322","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4949322/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4949322/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes Dev","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:3931526","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4949322","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27401552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27401552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:genesdev:30/13/1492","doi":null,"is_oa":false,"landing_page_url":"http://genesdev.cshlp.org/cgi/content/short/30/13/1492","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1101/gad.282145.116","doi":"https://doi.org/10.1101/gad.282145.116","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.282145.116","pdf_url":null,"source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6064198778","display_name":"The consequences of RB-loss","funder_award_id":"R01GM117413","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8123321803","display_name":"Dissection and manipulation of RB function","funder_award_id":"R01CA163698","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2471978271.pdf","grobid_xml":"https://content.openalex.org/works/W2471978271.grobid-xml"},"referenced_works_count":153,"referenced_works":["https://openalex.org/W81266651","https://openalex.org/W1464936406","https://openalex.org/W1486122524","https://openalex.org/W1571624349","https://openalex.org/W1576230644","https://openalex.org/W1602446144","https://openalex.org/W1815509520","https://openalex.org/W1839851754","https://openalex.org/W1903523058","https://openalex.org/W1970269422","https://openalex.org/W1974215660","https://openalex.org/W1975570973","https://openalex.org/W1978265144","https://openalex.org/W1982622947","https://openalex.org/W1983827654","https://openalex.org/W1984328656","https://openalex.org/W1984494355","https://openalex.org/W1986960362","https://openalex.org/W1987084496","https://openalex.org/W1987369248","https://openalex.org/W1990213657","https://openalex.org/W1991192947","https://openalex.org/W1994817833","https://openalex.org/W1996345793","https://openalex.org/W1999330214","https://openalex.org/W2000258078","https://openalex.org/W2000650776","https://openalex.org/W2003553263","https://openalex.org/W2009348610","https://openalex.org/W2009910507","https://openalex.org/W2009970436","https://openalex.org/W2010164793","https://openalex.org/W2010493387","https://openalex.org/W2011836786","https://openalex.org/W2015891530","https://openalex.org/W2017066141","https://openalex.org/W2018690046","https://openalex.org/W2021437940","https://openalex.org/W2021579554","https://openalex.org/W2027447321","https://openalex.org/W2029080338","https://openalex.org/W2029411138","https://openalex.org/W2032165583","https://openalex.org/W2033496263","https://openalex.org/W2034440981","https://openalex.org/W2035205419","https://openalex.org/W2035443068","https://openalex.org/W2035882662","https://openalex.org/W2037338364","https://openalex.org/W2038500217","https://openalex.org/W2039798579","https://openalex.org/W2040189858","https://openalex.org/W2040834490","https://openalex.org/W2046221670","https://openalex.org/W2049133549","https://openalex.org/W2052540412","https://openalex.org/W2055164947","https://openalex.org/W2061205449","https://openalex.org/W2061603582","https://openalex.org/W2061780077","https://openalex.org/W2066680166","https://openalex.org/W2067873262","https://openalex.org/W2071333117","https://openalex.org/W2072581924","https://openalex.org/W2075430338","https://openalex.org/W2076225407","https://openalex.org/W2077350313","https://openalex.org/W2078427074","https://openalex.org/W2078990441","https://openalex.org/W2080157553","https://openalex.org/W2082826505","https://openalex.org/W2084069837","https://openalex.org/W2084544581","https://openalex.org/W2084833108","https://openalex.org/W2086096251","https://openalex.org/W2087374769","https://openalex.org/W2088382836","https://openalex.org/W2090807626","https://openalex.org/W2094525939","https://openalex.org/W2095885501","https://openalex.org/W2099742439","https://openalex.org/W2102563754","https://openalex.org/W2104043003","https://openalex.org/W2104106878","https://openalex.org/W2105081612","https://openalex.org/W2107480474","https://openalex.org/W2107804869","https://openalex.org/W2108643617","https://openalex.org/W2111155422","https://openalex.org/W2113239433","https://openalex.org/W2113473628","https://openalex.org/W2118874870","https://openalex.org/W2120709000","https://openalex.org/W2122065834","https://openalex.org/W2123192739","https://openalex.org/W2123538192","https://openalex.org/W2123611122","https://openalex.org/W2125037952","https://openalex.org/W2125096346","https://openalex.org/W2125789330","https://openalex.org/W2126821691","https://openalex.org/W2129781589","https://openalex.org/W2130509453","https://openalex.org/W2131029596","https://openalex.org/W2134964281","https://openalex.org/W2136006294","https://openalex.org/W2136158663","https://openalex.org/W2136792748","https://openalex.org/W2137177885","https://openalex.org/W2137187201","https://openalex.org/W2138772083","https://openalex.org/W2139132031","https://openalex.org/W2139400940","https://openalex.org/W2140554630","https://openalex.org/W2141227083","https://openalex.org/W2142877023","https://openalex.org/W2143404258","https://openalex.org/W2144790402","https://openalex.org/W2146843058","https://openalex.org/W2148345265","https://openalex.org/W2149139293","https://openalex.org/W2149434326","https://openalex.org/W2149686649","https://openalex.org/W2149852478","https://openalex.org/W2150366724","https://openalex.org/W2150451425","https://openalex.org/W2151484351","https://openalex.org/W2151688340","https://openalex.org/W2151812144","https://openalex.org/W2152616419","https://openalex.org/W2154133788","https://openalex.org/W2154626333","https://openalex.org/W2155009866","https://openalex.org/W2158936746","https://openalex.org/W2159058669","https://openalex.org/W2159969460","https://openalex.org/W2161611854","https://openalex.org/W2161853394","https://openalex.org/W2162627731","https://openalex.org/W2162972982","https://openalex.org/W2163570884","https://openalex.org/W2164026919","https://openalex.org/W2165860917","https://openalex.org/W2165868533","https://openalex.org/W2166229764","https://openalex.org/W2166388925","https://openalex.org/W2170550202","https://openalex.org/W2219817965","https://openalex.org/W2298332800","https://openalex.org/W2314455777","https://openalex.org/W2335445771","https://openalex.org/W2397317955","https://openalex.org/W2567749685"],"related_works":["https://openalex.org/W2143536302","https://openalex.org/W1990213657","https://openalex.org/W4403982821","https://openalex.org/W29276055","https://openalex.org/W4290998656","https://openalex.org/W4234739424","https://openalex.org/W79059464","https://openalex.org/W2418540450","https://openalex.org/W1912032437","https://openalex.org/W107073697"],"abstract_inverted_index":{"The":[0],"retinoblastoma":[1],"susceptibility":[2],"gene":[3,10,29,73],"(RB1)":[4],"was":[5],"the":[6,47,66,128,135,138,147,152],"first":[7],"tumor":[8,69],"suppressor":[9,70],"to":[11,163],"be":[12,161],"molecularly":[13],"defined.":[14],"RB1":[15,51,58],"mutations":[16],"occur":[17],"in":[18,35,105,118],"almost":[19],"all":[20],"familial":[21],"and":[22,27,53,78,121],"sporadic":[23],"forms":[24],"of":[25,38,43,50,56,68,83,96,99,137,149,158],"retinoblastoma,":[26],"this":[28],"is":[30,59,79],"mutated":[31],"at":[32,134],"variable":[33],"frequencies":[34],"a":[36,63,80,93],"variety":[37],"other":[39],"human":[40],"cancers.":[41],"Because":[42],"its":[44,54],"early":[45],"discovery,":[46],"recessive":[48],"nature":[49],"mutations,":[52],"frequency":[55],"inactivation,":[57],"often":[60],"described":[61],"as":[62],"prototype":[64],"for":[65,127,167],"class":[67],"genes.":[71],"Its":[72],"product":[74],"(pRB)":[75],"regulates":[76],"transcription":[77],"negative":[81],"regulator":[82],"cell":[84],"proliferation.":[85],"Although":[86],"these":[87],"general":[88],"features":[89],"are":[90],"well":[91],"established,":[92],"precise":[94],"description":[95],"pRB's":[97],"mechanism":[98],"action":[100],"has":[101],"remained":[102],"elusive.":[103],"Indeed,":[104],"many":[106],"regards,":[107],"pRB":[108,119,139,143],"remains":[109],"an":[110],"enigma.":[111],"This":[112],"review":[113],"summarizes":[114],"some":[115],"recent":[116],"developments":[117],"research":[120],"focuses":[122],"on":[123],"progress":[124],"toward":[125],"answers":[126],"three":[129],"fundamental":[130],"questions":[131],"that":[132],"sit":[133],"heart":[136],"literature:":[140],"What":[141],"does":[142,146],"do?":[144],"How":[145,154],"inactivation":[148],"RB":[150,159],"change":[151],"cell?":[153],"can":[155],"our":[156],"knowledge":[157],"function":[160],"exploited":[162],"provide":[164],"better":[165],"treatment":[166],"cancer":[168],"patients?":[169]},"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":34},{"year":2023,"cited_by_count":58},{"year":2022,"cited_by_count":50},{"year":2021,"cited_by_count":75},{"year":2020,"cited_by_count":48},{"year":2019,"cited_by_count":52},{"year":2018,"cited_by_count":37},{"year":2017,"cited_by_count":35},{"year":2016,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-07-22T00:00:00"}
