{"id":"https://openalex.org/W2471965950","doi":null,"title":"Comparison of numerical and phenotypic leukocyte changes during constant hydrocortisone infusion in normal humans with those in thermally injured patients.","display_name":"Comparison of numerical and phenotypic leukocyte changes during constant hydrocortisone infusion in normal humans with those in thermally injured patients.","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W2471965950","mag":"2471965950","pmid":"https://pubmed.ncbi.nlm.nih.gov/3589906"},"language":"en","primary_location":{"id":"pmid:3589906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3589906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery, gynecology & obstetrics","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023715041","display_name":"Calvano Se","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S E Calvano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080378436","display_name":"Albert Jd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J D Albert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110383218","display_name":"Adrian Legaspi","orcid":"https://orcid.org/0000-0001-9566-2637","observed_orcids":["https://orcid.org/0000-0001-9566-2637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Legaspi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078758603","display_name":"BRAIN C. ORGAN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B C Organ","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030646863","display_name":"Kevin J. Tracey","orcid":"https://orcid.org/0000-0003-1884-6314","observed_orcids":["https://orcid.org/0000-0003-1884-6314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K J Tracey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016708712","display_name":"Lowry Sf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S F Lowry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048851975","display_name":"Shires Gt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G T Shires","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058514833","display_name":"A C Antonacci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C Antonacci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4659,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.78825681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"164","issue":"6","first_page":"509","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9440000057220459},{"id":"https://openalex.org/keywords/burns","display_name":"burns","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lymphocyte-subsets","display_name":"lymphocyte subsets","score":0.8180000185966492},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7310000061988831},{"id":"https://openalex.org/keywords/t4-lymphocytes","display_name":"T4 lymphocytes","score":0.6380000114440918},{"id":"https://openalex.org/keywords/t8-lymphocytes","display_name":"T8 lymphocytes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.7409999966621399},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/monocytopenia","display_name":"monocytopenia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/granulocytosis","display_name":"granulocytosis","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.795997142791748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6843999624252319},{"id":"https://openalex.org/C2781206299","wikidata":"https://www.wikidata.org/wiki/Q3775781","display_name":"Granulocytosis","level":3,"score":0.5571324229240417},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5450832843780518},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5117873549461365},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49169665575027466},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.4714166820049286},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.45701080560684204},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3169090747833252},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16673952341079712},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.13781869411468506}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3589906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3589906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery, gynecology & obstetrics","raw_type":"Comparative Study"},{"id":"mag:2471965950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3589906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4240597143","https://openalex.org/W2089278426","https://openalex.org/W1999693700","https://openalex.org/W2004496707","https://openalex.org/W2092067281","https://openalex.org/W1987943103","https://openalex.org/W2410580320","https://openalex.org/W4299308763","https://openalex.org/W2041493456","https://openalex.org/W2626592930"],"abstract_inverted_index":{"Twenty-four":[0],"to":[1,42,96,103,149,157],"48":[2,104],"hours":[3,105],"after":[4,106,112],"thermal":[5,107],"injury,":[6],"percentages":[7,114,183,194,203],"and":[8,111,115,121,127,175,187,199,221,234,247],"number":[9],"of":[10,40,64,85,117,160,184,195,204,214,218,231,245,269],"T":[11,24,51,72],"X":[12,25,52,73],"mu":[13,53],"or":[14,20,27,54,197],"T4":[15,55,186,220,248],"lymphocytes":[16,129,236],"decrease":[17,49,70],"with":[18,138,142,167],"little":[19],"no":[21,190],"change":[22],"in":[23,50,71,182,193,202,209,280],"gamma":[26],"T8":[28,196],"cells.":[29,75,206],"Additionally,":[30,177],"the":[31,69,158,265,274,281],"plasma":[32,92,145],"hydrocortisone":[33,41,65,86,146,227,260,270],"level":[34,147],"is":[35,271],"extremely":[36],"elevated.":[37],"Since":[38],"administration":[39],"normal":[43,79],"humans":[44,80],"also":[45],"produces":[46],"a":[47],"specific":[48],"lymphocytes,":[56,118,189],"it":[57],"was":[58,254],"hypothesized":[59],"that":[60,91,99,267,278],"burn":[61,215],"induced":[62],"elevations":[63],"were":[66,81,94,130,136,179],"responsible":[67,272],"for":[68,87,140,165,273],"mu/T4":[74],"In":[76],"this":[77,251],"study,":[78],"administered":[82],"constant":[83],"infusions":[84],"six":[88],"hours,":[89],"such":[90],"levels":[93],"increased":[95],"an":[97,200],"extent":[98],"mimics":[100],"those":[101,139,213],"24":[102],"injury.":[108],"Before,":[109],"during":[110,154,226,259],"infusion,":[113,155],"numbers":[116,230,244],"monocytes,":[119],"granulocytes":[120],"T3,":[122,185,219],"T4,":[123],"T8,":[124,232],"T11,":[125],"HLA-DR":[126,198,233],"Leu7":[128,235],"quantified":[131],"by":[132],"flow":[133],"cytometry.":[134],"Results":[135],"compared":[137],"patients":[141,166,241],"burns.":[143,168],"The":[144],"rose":[148],"49.0":[150],"micrograms":[151,162],"per":[152,163],"deciliter":[153,164],"similar":[156],"mean":[159],"47.5":[161],"Infused":[169],"volunteers":[170],"showed":[171,242],"significant":[172,180,191],"lymphopenia,":[173],"monocytopenia":[174],"granulocytosis.":[176],"there":[178],"decreases":[181],"T11":[188,222],"changes":[192,208,277],"increase":[201],"Leu7+":[205],"These":[207,262],"lymphocyte":[210,275],"subsets":[211],"mimicked":[212],"patients.":[216],"Numbers":[217],"cells":[223],"significantly":[224],"decreased":[225,243],"infusion":[228],"while":[229],"did":[237],"not":[238,255],"change.":[239],"Burn":[240],"T3":[246],"cells,":[249],"but":[250],"T3/T4":[252],"lymphopenia":[253],"as":[256,258],"great":[257],"infusion.":[261],"results":[263],"support":[264],"hypothesis":[266],"elevation":[268],"phenotypic":[276],"occur":[279],"early":[282],"postburn":[283],"period.":[284]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-07-22T00:00:00"}