{"id":"https://openalex.org/W2471908755","doi":null,"title":"IgG-anticardiolipin-antibodies are markers for cerebral and peripheral artery disease.","display_name":"IgG-anticardiolipin-antibodies are markers for cerebral and peripheral artery disease.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2471908755","mag":"2471908755","pmid":"https://pubmed.ncbi.nlm.nih.gov/1621434"},"language":"en","primary_location":{"id":"pmid:1621434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1621434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"VASA. Zeitschrift fur Gefasskrankheiten","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022775023","display_name":"Ingeborg Friehs","orcid":"https://orcid.org/0000-0002-2631-2972","observed_orcids":["https://orcid.org/0000-0002-2631-2972"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]},{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"I Friehs","raw_affiliation_strings":["Department of Vascular Surgery, University of Graz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, University of Graz","institution_ids":["https://openalex.org/I15766117","https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049445187","display_name":"Bernd Eber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Eber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111872094","display_name":"Gerhard B. Friehs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Friehs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045173427","display_name":"Werner Langsteger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Langsteger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111541101","display_name":"G Koch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Koch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.38407527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"21","issue":"2","first_page":"158","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticardiolipin-antibodies","display_name":"anticardiolipin antibodies","score":0.9869999885559082},{"id":"https://openalex.org/keywords/igg-anticardiolipin-antibodies","display_name":"IgG anticardiolipin antibodies","score":0.8799999952316284},{"id":"https://openalex.org/keywords/igm-anticardiolipin-antibodies","display_name":"IgM anticardiolipin antibodies","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.7839999794960022},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.9670000076293945},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.800000011920929},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.578000009059906},{"id":"https://openalex.org/keywords/cardiovascular-risk-markers","display_name":"cardiovascular risk markers","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.833861231803894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6038843393325806},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.559343159198761},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5327845811843872},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.5060097575187683},{"id":"https://openalex.org/C3018762881","wikidata":"https://www.wikidata.org/wiki/Q3774511","display_name":"Anticardiolipin antibodies","level":3,"score":0.47526687383651733},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.45275354385375977},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4495474398136139},{"id":"https://openalex.org/C2776670291","wikidata":"https://www.wikidata.org/wiki/Q1779300","display_name":"Connective tissue disease","level":4,"score":0.41819077730178833},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4059208035469055},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35793763399124146},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.35702309012413025},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35633817315101624}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002308","descriptor_name":"Cardiolipins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002341","descriptor_name":"Carotid Artery Thrombosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002343","descriptor_name":"Carotid Artery, Internal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002542","descriptor_name":"Intracranial Embolism and Thrombosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1621434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1621434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"VASA. Zeitschrift fur Gefasskrankheiten","raw_type":"Clinical Trial"},{"id":"mag:2471908755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1621434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1976210934","https://openalex.org/W2360377293","https://openalex.org/W2398825946","https://openalex.org/W2415579363","https://openalex.org/W2105805234","https://openalex.org/W2360849541","https://openalex.org/W2049776824","https://openalex.org/W2073127745","https://openalex.org/W7097630958","https://openalex.org/W2470825805"],"abstract_inverted_index":{"Anticardiolipin-antibodies":[0],"are":[1],"antibodies":[2],"to":[3,144,202],"phospholipids":[4],"which":[5],"were":[6,24,53,119,132,153],"first":[7],"detected":[8],"in":[9,26,125,135,155,178,217],"patients":[10,27,41,61,69,78,90,113,136,159,218],"with":[11,28,62,70,137,194],"arterial":[12],"thrombosis":[13],"and":[14,22,55,82,88,101,117,128,139,163,196,209,213],"lupus":[15],"erythematosus.":[16],"In":[17,95],"this":[18],"prospective":[19],"study,":[20],"IgG-":[21,195],"IgM-anticardiolipin-antibodies":[23],"determined":[25,216],"cerebral":[29,81,138,162,208],"and/or":[30,191],"peripheral":[31,71,83,140,164,210],"artery":[32,72,84,141,165,211],"disease":[33,65,73,85,142,166,212],"but":[34],"without":[35],"autoimmune":[36],"disorders.":[37],"123":[38],"randomly":[39],"selected":[40],"(88":[42],"males,":[43],"35":[44,68,77,89],"females;":[45],"mean:":[46],"65":[47],"+/-":[48],"10,":[49],"range:":[50],"41-85":[51],"years)":[52],"included":[54],"divided":[56],"into":[57],"four":[58,105,180],"groups:":[59],"18":[60],"isolated":[63],"cerebrovascular":[64],"(group":[66,75,86,93],"A),":[67],"only":[74],"B),":[76],"suffering":[79],"from":[80,161],"C)":[87],"as":[91],"controls":[92,145],"D).":[94],"family":[96],"history,":[97],"cholesterol,":[98],"blood":[99],"sugar":[100],"prothrombin":[102],"time":[103],"the":[104,169,179],"patient":[106],"groups":[107,126],"did":[108,173],"not":[109,174],"differ":[110],"significantly,":[111],"whereas":[112],"of":[114],"group":[115,156],"B":[116],"C":[118,157],"more":[120],"often":[121],"smokers":[122],"than":[123,148],"those":[124],"A":[127],"D.":[129],"However,":[130],"IgG-anticardiolipin-antibody-levels":[131],"significantly":[133],"elevated":[134,199],"compared":[143],"(p":[146],"less":[147],"0.01).":[149],"The":[150],"highest":[151],"values":[152],"seen":[154],"where":[158],"suffered":[160],"(n.s.).":[167],"On":[168],"other":[170],"hand,":[171],"IgM-anticardiolipin-antibody-levels":[172],"show":[175],"any":[176],"differences":[177],"groups.":[181],"Furthermore,":[182],"there":[183],"was":[184],"no":[185],"correlation":[186],"between":[187],"vascular":[188],"risk":[189],"factors":[190],"laboratory":[192],"findings":[193],"IgM-antibody-levels.":[197],"Thus,":[198],"IgG-anticardiolipin-antibodies":[200],"appear":[201],"be":[203,215],"independent":[204],"markers":[205],"for":[206],"severe":[207],"should":[214],"at":[219],"increased":[220],"risk.":[221]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}