{"id":"https://openalex.org/W2471901435","doi":null,"title":"Glycosaminoglycans in normal and atherosclerotic human coronary arteries.","display_name":"Glycosaminoglycans in normal and atherosclerotic human coronary arteries.","publication_year":1986,"publication_date":"1986-04-01","ids":{"openalex":"https://openalex.org/W2471901435","mag":"2471901435","pmid":"https://pubmed.ncbi.nlm.nih.gov/3083156"},"language":"en","primary_location":{"id":"pmid:3083156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3083156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014220812","display_name":"Seppo Yl\u00e4\u2010Herttuala","orcid":"https://orcid.org/0000-0001-7593-2708","observed_orcids":["https://orcid.org/0000-0001-7593-2708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Yl\u00e4-Herttuala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017729237","display_name":"H. Sumuvuori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Sumuvuori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029451372","display_name":"Kari O. Karkola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Karkola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047643849","display_name":"Mikko M\u00f6tt\u00f6nen","orcid":"https://orcid.org/0000-0001-5084-2298","observed_orcids":["https://orcid.org/0000-0001-5084-2298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M M\u00f6tt\u00f6nen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112158732","display_name":"Tapio Nikkari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nikkari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6133,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.83023001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"54","issue":"4","first_page":"402","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":1.0},{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.6790000200271606},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/sulfated-glycosaminoglycans","display_name":"sulfated glycosaminoglycans","score":0.8840000033378601},{"id":"https://openalex.org/keywords/chondroitin-sulfate-a","display_name":"chondroitin sulfate A","score":0.972000002861023},{"id":"https://openalex.org/keywords/chondroitin-sulfate-c","display_name":"chondroitin sulfate C","score":1.0},{"id":"https://openalex.org/keywords/dermatan-sulfate","display_name":"dermatan sulfate","score":1.0},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/intimal-thickening","display_name":"intimal thickening","score":0.906000018119812},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/connective-tissue","display_name":"connective tissue","score":0.6840000152587891},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2778066728","wikidata":"https://www.wikidata.org/wiki/Q2335618","display_name":"Dermatan sulfate","level":4,"score":0.9232463836669922},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.8513540029525757},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.729468584060669},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.6108411550521851},{"id":"https://openalex.org/C2776735749","wikidata":"https://www.wikidata.org/wiki/Q4862650","display_name":"Chondroitin","level":3,"score":0.6082261800765991},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.6073934435844421},{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.5389038324356079},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.5061163306236267},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4964943528175354},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.48626840114593506},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.4192030131816864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4015335738658905},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3885457515716553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3407668471336365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31178754568099976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18704378604888916}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002809","descriptor_name":"Chondroitin Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003871","descriptor_name":"Dermatan Sulfate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004588","descriptor_name":"Electrophoresis, Cellulose Acetate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3083156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3083156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:2471901435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3083156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965843169","https://openalex.org/W2334161762","https://openalex.org/W2146844497","https://openalex.org/W2042744084","https://openalex.org/W2062578590","https://openalex.org/W2122133117","https://openalex.org/W1973692647","https://openalex.org/W17602763","https://openalex.org/W6999152630","https://openalex.org/W2081863011"],"abstract_inverted_index":{"Glycosaminoglycans":[0],"(GAGs)":[1],"were":[2,22,63,105,126],"studied":[3],"in":[4,65,111,117,123,132,140,192],"normal":[5,84,124,167],"and":[6,24,69,71,92,96,169,182],"atherosclerotic":[7],"coronary":[8,85],"arteries":[9,86],"of":[10,31,44,76,89,121,152,157,171,178,189],"15-":[11],"to":[12,42,58,129,145,148],"60-year-old":[13],"Finnish":[14],"men":[15],"who":[16],"had":[17],"died":[18],"accidentally.":[19],"The":[20,29,60,114,138],"GAGs":[21,33,122,191],"fractionated":[23],"quantified":[25],"with":[26,51,80,100,174],"electrophoretic":[27],"techniques.":[28],"contents":[30,88,188],"sulfated":[32,190],"(micrograms/cm2":[34],"vessel":[35,46],"surface":[36,47],"area)":[37],"increased":[38,98,155],"continuously":[39],"until":[40],"20":[41],"30%":[43],"the":[45,74,87,103,118,166,172,187],"area":[48],"was":[49],"covered":[50],"fibrous":[52],"plaques,":[53],"after":[54],"which":[55,77,153,184],"they":[56],"started":[57],"decrease.":[59],"largest":[61],"increases":[62,186],"seen":[64],"chondroitin":[66,93],"sulfates":[67,94],"A":[68,95],"C":[70,97],"dermatan":[72,90],"sulfate,":[73],"former":[75],"rose":[78],"earlier":[79],"lesion":[81,136],"development.":[82,137],"In":[83],"sulfate":[91],"significantly":[99],"age,":[101],"but":[102],"rises":[104],"much":[106],"smaller":[107],"than":[108],"those":[109,130],"found":[110,131],"affected":[112,133,193],"vessels.":[113],"age-related":[115],"changes":[116],"percentage":[119],"composition":[120],"coronaries":[125,134],"qualitatively":[127],"similar":[128],"during":[135],"alterations":[139],"arterial":[141,162],"GAGs,":[142],"therefore,":[143],"seem":[144],"be":[146],"related":[147],"two":[149],"processes,":[150],"both":[151],"involve":[154],"formation":[156],"connective":[158],"tissue":[159],"components":[160],"by":[161],"smooth":[163],"muscle":[164],"cells:":[165],"growth":[168],"maturation":[170],"vessels":[173],"a":[175],"slow":[176],"development":[177],"diffuse":[179],"intimal":[180],"thickening,":[181],"atherogenesis,":[183],"greatly":[185],"arteries.":[194]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
