{"id":"https://openalex.org/W2471764451","doi":"https://doi.org/10.4269/ajtmh.1985.34.216","title":"In Vitro Culture of Two Populations (Dividing and Nondividing) of Exoerythrocytic Parasites of Plasmodium Vivax","display_name":"In Vitro Culture of Two Populations (Dividing and Nondividing) of Exoerythrocytic Parasites of Plasmodium Vivax","publication_year":1985,"publication_date":"1985-03-01","ids":{"openalex":"https://openalex.org/W2471764451","doi":"https://doi.org/10.4269/ajtmh.1985.34.216","mag":"2471764451","pmid":"https://pubmed.ncbi.nlm.nih.gov/2984950"},"language":"en","primary_location":{"id":"doi:10.4269/ajtmh.1985.34.216","doi":"https://doi.org/10.4269/ajtmh.1985.34.216","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.1985.34.216","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Tropical Medicine and Hygiene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063342340","display_name":"Michael R. Hollingdale","orcid":"https://orcid.org/0000-0002-2343-3824","observed_orcids":["https://orcid.org/0000-0002-2343-3824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael R. Hollingdale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104058708","display_name":"Alan L. Schwartz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan L. Schwartz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109392311","display_name":"Carlos C. Campbell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos C. Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103513838","display_name":"William E. Collins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William E. Collins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7074,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.9608428,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"34","issue":"2","first_page":"216","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12178","display_name":"Bird parasitology and diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-vivax","display_name":"Plasmodium vivax","score":1.0},{"id":"https://openalex.org/keywords/schizonts","display_name":"schizonts","score":0.7149999737739563},{"id":"https://openalex.org/keywords/merozoites","display_name":"merozoites","score":0.6959999799728394},{"id":"https://openalex.org/keywords/parasite-persistence","display_name":"parasite persistence","score":0.4580000042915344},{"id":"https://openalex.org/keywords/monoclonal-antibody-reactivity","display_name":"monoclonal antibody reactivity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/in-vitro-culture","display_name":"in vitro culture","score":0.6209999918937683},{"id":"https://openalex.org/keywords/parasite-differentiation","display_name":"parasite differentiation","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9035091400146484},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.7114845514297485},{"id":"https://openalex.org/C2779997623","wikidata":"https://www.wikidata.org/wiki/Q311376","display_name":"Plasmodium vivax","level":4,"score":0.6992403864860535},{"id":"https://openalex.org/C2778566189","wikidata":"https://www.wikidata.org/wiki/Q101274","display_name":"Protozoa","level":2,"score":0.6875640153884888},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5673282742500305},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5573642253875732},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5568653345108032},{"id":"https://openalex.org/C2781023229","wikidata":"https://www.wikidata.org/wiki/Q193030","display_name":"Apicomplexa","level":4,"score":0.5526960492134094},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.5040625333786011},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.499218225479126},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3309658169746399},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.32991504669189453},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.28754347562789917},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.26311081647872925},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.254901647567749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08819624781608582},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001399","descriptor_name":"Azure Stains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4269/ajtmh.1985.34.216","doi":"https://doi.org/10.4269/ajtmh.1985.34.216","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.1985.34.216","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Tropical Medicine and Hygiene","raw_type":"journal-article"},{"id":"pmid:2984950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2984950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2420274735","https://openalex.org/W2414395039","https://openalex.org/W2237643093","https://openalex.org/W4230129891","https://openalex.org/W2026870276","https://openalex.org/W2416106311","https://openalex.org/W2024180269","https://openalex.org/W6977524315","https://openalex.org/W2147282197","https://openalex.org/W2409515770"],"abstract_inverted_index":{"Plasmodium":[0],"vivax":[1,62,77],"sporozoites":[2],"invaded":[3],"human":[4],"hepatoma":[5],"cells":[6],"and":[7,37],"differentiated":[8],"into":[9],"2":[10,73],"types":[11],"of":[12,20,30,60,75,81],"exoerythrocytic":[13],"(EE)":[14],"parasites.":[15],"One":[16],"group":[17,34],"was":[18,35,86],"composed":[19],"actively":[21],"dividing":[22],"schizonts,":[23],"which":[24],"released":[25],"merozoites":[26],"after":[27,39],"9":[28],"days":[29],"culture.":[31,46],"The":[32],"second":[33],"nondividing":[36],"persisted":[38],"the":[40,45,56,65,72,79],"primary":[41],"schizonts":[42,48,82],"disappeared":[43],"from":[44],"EE":[47],"progressively":[49],"lost":[50],"reactivity":[51],"to":[52,55,83],"monoclonal":[53],"antibodies":[54],"surface-protective":[57],"protein":[58],"antigen":[59],"P.":[61,76],"sporozoites,":[63],"but":[64],"persisting":[66,84],"parasites":[67,85],"remained":[68],"strongly":[69],"reactive.":[70],"In":[71],"strains":[74],"studied,":[78],"ratio":[80],"approximately":[87],"equal.":[88]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}