{"id":"https://openalex.org/W2471756785","doi":null,"title":"Myelin basic protein in lipid-bound form induces experimental allergic encephalomyelitis and demyelination in Lewis rat.","display_name":"Myelin basic protein in lipid-bound form induces experimental allergic encephalomyelitis and demyelination in Lewis rat.","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W2471756785","mag":"2471756785","pmid":"https://pubmed.ncbi.nlm.nih.gov/1716398"},"language":"en","primary_location":{"id":"pmid:1716398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1716398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neurologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015612812","display_name":"B. Zehetbauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"B Zehetbauer","raw_affiliation_strings":["Department of Neurology, University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018281423","display_name":"Luca Massacesi","orcid":"https://orcid.org/0000-0001-5083-372X","observed_orcids":["https://orcid.org/0000-0001-5083-372X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Massacesi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006193342","display_name":"Grazia Maria Liuzzi","orcid":"https://orcid.org/0000-0001-5692-9335","observed_orcids":["https://orcid.org/0000-0001-5692-9335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G M Liuzzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022541648","display_name":"Marco Vergelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Vergelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008956809","display_name":"J. Olivotto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Olivotto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"L Grassi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Grassi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000042862","display_name":"Paolo Riccio","orcid":"https://orcid.org/0000-0002-7713-5718","observed_orcids":["https://orcid.org/0000-0002-7713-5718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Riccio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110915446","display_name":"L. A. Amaducci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Amaducci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.148,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.79803436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"13","issue":"2","first_page":"121","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":1.0},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.968999981880188},{"id":"https://openalex.org/keywords/lewis-rats","display_name":"Lewis rats","score":0.6850000023841858},{"id":"https://openalex.org/keywords/myelin-lipids","display_name":"myelin lipids","score":0.7929999828338623},{"id":"https://openalex.org/keywords/autoimmune-demyelinating-disease","display_name":"autoimmune demyelinating disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.887035608291626},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.8347691297531128},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.7899142503738403},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5736476182937622},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.540307343006134},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.5238609313964844},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5016193389892578},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4145599603652954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.401075541973114},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3994283974170685},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18435442447662354}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:1716398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1716398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neurologica","raw_type":"Journal Article"},{"id":"pmh:oai:ricerca.uniba.it:11586/33138","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/33138","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2471756785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1716398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2139161407","https://openalex.org/W2416157592","https://openalex.org/W1533809286","https://openalex.org/W2418371931","https://openalex.org/W2054324543","https://openalex.org/W1971071984","https://openalex.org/W812587258","https://openalex.org/W1997711752","https://openalex.org/W2021273175","https://openalex.org/W1974030997"],"abstract_inverted_index":{"Myelin":[0],"basic":[1],"protein":[2],"(MBP)":[3],"was":[4,27],"isolated":[5],"from":[6],"guinea-pig":[7],"spinal":[8],"cord":[9],"in":[10,33,38,100,122,128],"a":[11,112],"form":[12],"retaining":[13],"the":[14,18,70,101,135],"binding":[15],"to":[16,29,40],"all":[17],"myelin":[19],"lipids.":[20],"This":[21],"new,":[22],"lipid-bound":[23],"and":[24,74,96,124],"native-like":[25],"preparation":[26],"used":[28,68],"immunize":[30],"Lewis":[31,54,88],"rats":[32,55,89,123],"complete":[34],"Freund's":[35],"adjuvant":[36],"(CFA)":[37],"order":[39],"produce":[41],"experimental":[42],"allergic":[43],"encephalomyelitis":[44],"(EAE).":[45],"The":[46,77,106],"clinical":[47,78],"features":[48],"were":[49],"compared":[50],"with":[51,57],"those":[52],"of":[53,72,134],"immunized":[56],"lipid-free":[58],"MBP":[59],"(LF-MBP),":[60],"myelin,":[61],"LF-MBP":[62,95],"+":[63],"octyl-POE":[64,75],"(the":[65],"non-ionic":[66],"detergent":[67],"for":[69,130],"purification":[71],"LB-MBP)":[73],"alone.":[76],"observation":[79],"indicate":[80],"that":[81,109],"LB-MBP":[82,110],"exerts":[83],"an":[84],"encephalitogenic":[85,114],"activity":[86],"on":[87],"which":[90,116],"is":[91,111],"more":[92,119],"intense":[93],"than":[94],"includes":[97],"demyelinating":[98,132],"lesions":[99],"central":[102],"nervous":[103],"system":[104],"(CNS).":[105],"data":[107],"suggest":[108],"new":[113],"antigen,":[115],"may":[117,125],"induce":[118],"intensive":[120],"immunization":[121],"be":[126],"relevant":[127],"humans":[129],"autoimmune":[131],"diseases":[133],"CNS.":[136]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
