{"id":"https://openalex.org/W2471363731","doi":"https://doi.org/10.1055/s-0038-1651339","title":"Determinants of the Formation and Activity of Factor V-phospholipid Complexes I. Influence of Phospholipid Structure","display_name":"Determinants of the Formation and Activity of Factor V-phospholipid Complexes I. Influence of Phospholipid Structure","publication_year":1975,"publication_date":"1975-01-01","ids":{"openalex":"https://openalex.org/W2471363731","doi":"https://doi.org/10.1055/s-0038-1651339","mag":"2471363731","pmid":"https://pubmed.ncbi.nlm.nih.gov/1237944"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1651339","doi":"https://doi.org/10.1055/s-0038-1651339","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1651339","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057342536","display_name":"Carol L Kandall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol L Kandall","raw_affiliation_strings":["Departments of Medicine and Pediatrics, Harvard Medical School, the Hematology Unit of the Massachusetts General Hospital, the Children\u2019s Hospital Medical Center, Boston, Massachusetts","University of San Francisco, Departments of Medicine and Clinical Pathology, Hematology Division, San Francisco, California 94122"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pediatrics, Harvard Medical School, the Hematology Unit of the Massachusetts General Hospital, the Children\u2019s Hospital Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"University of San Francisco, Departments of Medicine and Clinical Pathology, Hematology Division, San Francisco, California 94122","institution_ids":["https://openalex.org/I76766440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103479296","display_name":"Stephen B. Shohet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B Shohet","raw_affiliation_strings":["Departments of Medicine and Pediatrics, Harvard Medical School, the Hematology Unit of the Massachusetts General Hospital, the Children\u2019s Hospital Medical Center, Boston, Massachusetts","University of San Francisco, Departments of Medicine and Clinical Pathology, Hematology Division, San Francisco, California 94122"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pediatrics, Harvard Medical School, the Hematology Unit of the Massachusetts General Hospital, the Children\u2019s Hospital Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"University of San Francisco, Departments of Medicine and Clinical Pathology, Hematology Division, San Francisco, California 94122","institution_ids":["https://openalex.org/I76766440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023031371","display_name":"T. K. Akinbami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. K Akinbami","raw_affiliation_strings":["Departments of Medicine and Pediatrics, Harvard Medical School, the Hematology Unit of the Massachusetts General Hospital, the Children\u2019s Hospital Medical Center, Boston, Massachusetts","University of San Francisco, Departments of Medicine and Clinical Pathology, Hematology Division, San Francisco, California 94122"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pediatrics, Harvard Medical School, the Hematology Unit of the Massachusetts General Hospital, the Children\u2019s Hospital Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"University of San Francisco, Departments of Medicine and Clinical Pathology, Hematology Division, San Francisco, California 94122","institution_ids":["https://openalex.org/I76766440"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W Colman","raw_affiliation_strings":["Departments of Medicine and Pediatrics, Harvard Medical School, the Hematology Unit of the Massachusetts General Hospital, the Children\u2019s Hospital Medical Center, Boston, Massachusetts","University of San Francisco, Departments of Medicine and Clinical Pathology, Hematology Division, San Francisco, California 94122"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pediatrics, Harvard Medical School, the Hematology Unit of the Massachusetts General Hospital, the Children\u2019s Hospital Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"University of San Francisco, Departments of Medicine and Clinical Pathology, Hematology Division, San Francisco, California 94122","institution_ids":["https://openalex.org/I76766440"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.50070836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"34","issue":"01","first_page":"256","last_page":"270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-v","display_name":"factor V","score":0.996999979019165},{"id":"https://openalex.org/keywords/phospholipid-structure","display_name":"phospholipid structure","score":0.8989999890327454},{"id":"https://openalex.org/keywords/phosphatidylethanolamine","display_name":"phosphatidylethanolamine","score":0.7929999828338623},{"id":"https://openalex.org/keywords/phosphatidyl-inositol","display_name":"phosphatidyl inositol","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cardiolipin","display_name":"cardiolipin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.9290000200271606},{"id":"https://openalex.org/keywords/lipid-unsaturation","display_name":"lipid unsaturation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/prothrombin-to-thrombin-conversion","display_name":"prothrombin to thrombin conversion","score":0.7699999809265137},{"id":"https://openalex.org/keywords/factor-xa","display_name":"factor Xa","score":0.9269999861717224},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.5049999952316284},{"id":"https://openalex.org/keywords/protein-lipid-interactions","display_name":"protein-lipid interactions","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.8429549932479858},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6431362628936768},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6019335985183716},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.570084273815155},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5256104469299316},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4858250617980957},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.4792352020740509},{"id":"https://openalex.org/C2781302388","wikidata":"https://www.wikidata.org/wiki/Q183453","display_name":"Cardiolipin","level":4,"score":0.4467615485191345},{"id":"https://openalex.org/C2779881004","wikidata":"https://www.wikidata.org/wiki/Q7451876","display_name":"Sepharose","level":3,"score":0.4161386787891388},{"id":"https://openalex.org/C54689828","wikidata":"https://www.wikidata.org/wiki/Q2029259","display_name":"Ultracentrifuge","level":2,"score":0.4142202138900757},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.375651478767395},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2625701427459717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1457207202911377},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002308","descriptor_name":"Cardiolipins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010714","descriptor_name":"Phosphatidylethanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010718","descriptor_name":"Phosphatidylserines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0038-1651339","doi":"https://doi.org/10.1055/s-0038-1651339","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1651339","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:1237944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1237944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis et diathesis haemorrhagica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2416060104","https://openalex.org/W2112490945","https://openalex.org/W156251551","https://openalex.org/W2152291506","https://openalex.org/W2170055916","https://openalex.org/W1980595834","https://openalex.org/W2080719447","https://openalex.org/W2944836531","https://openalex.org/W2045112356","https://openalex.org/W1968049480"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"showed":[2],"that":[3,40,80,133],"factor":[4,41,66,100,134,159,171],"V":[5,42,67,101,135],"consists":[6],"of":[7,27,56,65,87,99,102,126,158,166,176,182,206,267,293,311,322,338],"multiple":[8],"oligomeric":[9],"forms":[10],"including":[11],"a":[12,28,44,50,57,138,142,197,243,260],"minor":[13],"component":[14,117],"(form":[15],"L)":[16],"which":[17,106,144,250,278,288],"contained":[18,107],"lipid":[19,45,71,146,239,258,300],"and":[20,35,111,269],"was":[21,76,118,178,185,208,224,234,242,271,315],"eluted":[22],"in":[23,62,96,173,237],"the":[24,33,38,63,97,156,164,174,189,204,264,323,336,339],"excluded":[25,119],"volume":[26],"Sepharose":[29,121],"4B":[30,122],"column.":[31],"In":[32,255,326],"present":[34,236],"following":[36],"study":[37],"hypothesis":[39],"is":[43,131,136,279,282],"requiring":[46],"protein":[47,143],"rather":[48,141],"than":[49,113,212,216,219,318],"lipoprotein":[51,75,89],"has":[52],"been":[53],"tested.":[54,179],"Modification":[55],"previous":[58],"purification":[59],"procedure":[60],"resulted":[61,95],"separation":[64],"from":[68,73,83,120,248],"lipoprotein.":[69],"The":[70,180],"extracted":[72],"this":[74,88,127,153],"qualitatively":[77],"similar":[78],"to":[79,162,168],"previously":[81],"isolated":[82],"form":[84],"L.":[85],"Removal":[86],"by":[90,170,309],"sucrose":[91],"density":[92],"gradient":[93],"ultracentrifugation":[94],"isolation":[98],"high":[103],"specific":[104,244],"activity":[105,207,270,337],"no":[108,252],"detectable":[109],"phospholipid":[110,190,195],"less":[112,316],"0.2%":[114],"cholesterol.":[115],"No":[116,230],"after":[123],"gel":[124],"filtration":[125],"purified":[128],"preparation.":[129],"It":[130],"concluded":[132],"not":[137,272],"lipoprotein,":[139],"but":[140],"requires":[145],"for":[147],"its":[148],"coagulant":[149],"properties.":[150],"To":[151],"define":[152],"requirement":[154],"further":[155],"ability":[157],"V-phospholipid":[160],"complexes":[161],"accelerate":[163],"conversion":[165],"prothrombin":[167],"thrombin":[169,183],"Xa":[172],"presence":[175],"calcium":[177],"rate":[181],"formation":[184],"highly":[186,280],"dependent":[187],"on":[188],"employed":[191],"with":[192],"each":[193],"active":[194,238,317],"exhibiting":[196],"characteristic":[198],"optimal":[199],"concentration.":[200],"At":[201,299],"250":[202],"muM,":[203,304],"order":[205],"phosphatidyl":[209,213,220,276,286,306,313,333],"ethanolamine":[210,307,314,334],"greater":[211,215,218],"inositol":[214],"cardiolipin":[217],"choline.":[221],"Phosphatidyl":[222],"serine":[223],"inert":[225],"at":[226],"all":[227],"concentrations":[228,301],"employed.":[229],"single":[231],"fatty":[232,245,295],"acid":[233,246],"consistently":[235],"preparations,":[240],"nor":[241],"absent":[247],"those":[249],"had":[251],"clotting":[253],"activity.":[254],"comparing":[256],"different":[257],"classes,":[259],"direct":[261],"relationship":[262],"between":[263],"overall":[265],"degree":[266],"unsaturation":[268],"observed.":[273],"However,":[274],"bovine":[275,312],"inositol,":[277,287],"unsaturated,":[281],"active,":[283],"while":[284],"plant":[285],"contains":[289],"only":[290],"trace":[291],"amounts":[292],"unsaturated":[294],"acids,":[296],"were":[297],"inert.":[298],"below":[302],"300":[303],"saturated":[305,332],"produced":[308],"hydrogenation":[310],"an":[319],"equal":[320],"concentration":[321],"native":[324,340],"lipid.":[325],"mixtures":[327],"containing":[328],"both":[329],"lipids,":[330],"artificially":[331],"potentiated":[335],"compound.":[341]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}