{"id":"https://openalex.org/W2471256249","doi":"https://doi.org/10.4103/0976-500x.184769","title":"L-asparaginase in the treatment of patients with acute lymphoblastic leukemia","display_name":"L-asparaginase in the treatment of patients with acute lymphoblastic leukemia","publication_year":2016,"publication_date":"2016-06-01","ids":{"openalex":"https://openalex.org/W2471256249","doi":"https://doi.org/10.4103/0976-500x.184769","mag":"2471256249","pmid":"https://pubmed.ncbi.nlm.nih.gov/27440950","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4936081"},"language":"en","primary_location":{"id":"doi:10.4103/0976-500x.184769","doi":"https://doi.org/10.4103/0976-500x.184769","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0976-500x.184769","pdf_url":null,"source":{"id":"https://openalex.org/S144901397","display_name":"Journal of Pharmacology and Pharmacotherapeutics","issn_l":"0976-500X","issn":["0976-500X","0976-5018"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacology and Pharmacotherapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4103/0976-500x.184769","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053519615","display_name":"Rachel A. Egler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachel A. Egler","raw_affiliation_strings":["Department of Pediatric Hematology/Oncology, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology/Oncology, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027519806","display_name":"Sanjay P. Ahuja","orcid":"https://orcid.org/0000-0002-0178-7947","observed_orcids":["https://orcid.org/0000-0002-0178-7947"]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay P. Ahuja","raw_affiliation_strings":["Department of Pediatric Hematology/Oncology, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology/Oncology, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034600739","display_name":"Yousif Matloub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yousif Matloub","raw_affiliation_strings":["Department of Pediatric Hematology/Oncology, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology/Oncology, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053519615"],"corresponding_institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"],"apc_list":{"value":800,"currency":"USD","value_usd":800},"apc_paid":{"value":800,"currency":"USD","value_usd":800},"fwci":15.339,"has_fulltext":false,"cited_by_count":345,"citation_normalized_percentile":{"value":0.99332552,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"62","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-asparaginase","display_name":"L-asparaginase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/childhood-acute-lymphoblastic-leukemia","display_name":"childhood acute lymphoblastic leukemia","score":0.7960000038146973},{"id":"https://openalex.org/keywords/adolescent-and-young-adult-leukemia","display_name":"adolescent and young adult leukemia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pegylated-asparaginase","display_name":"pegylated asparaginase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hypersensitivity","display_name":"hypersensitivity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.6589999794960022},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7799999713897705},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.953000009059906},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2778904437","wikidata":"https://www.wikidata.org/wiki/Q105296036","display_name":"Asparaginase","level":4,"score":0.9006875157356262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.730036199092865},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.6315497159957886},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6068541407585144},{"id":"https://openalex.org/C2778495000","wikidata":"https://www.wikidata.org/wiki/Q134827","display_name":"Erwinia","level":3,"score":0.5003869533538818},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4700153172016144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34207215905189514},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.341001033782959},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3271036148071289},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10821333527565002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09954744577407837},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/0976-500x.184769","doi":"https://doi.org/10.4103/0976-500x.184769","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0976-500x.184769","pdf_url":null,"source":{"id":"https://openalex.org/S144901397","display_name":"Journal of Pharmacology and Pharmacotherapeutics","issn_l":"0976-500X","issn":["0976-500X","0976-5018"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacology and Pharmacotherapeutics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3916607","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4936081","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4936081","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4936081","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Pharmacol Pharmacother","raw_type":"Text"},{"id":"pmid:27440950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27440950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacology & pharmacotherapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4103/0976-500x.184769","doi":"https://doi.org/10.4103/0976-500x.184769","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0976-500x.184769","pdf_url":null,"source":{"id":"https://openalex.org/S144901397","display_name":"Journal of Pharmacology and Pharmacotherapeutics","issn_l":"0976-500X","issn":["0976-500X","0976-5018"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacology and Pharmacotherapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W20112094","https://openalex.org/W142226155","https://openalex.org/W1506630672","https://openalex.org/W1510505199","https://openalex.org/W1515224725","https://openalex.org/W1528693378","https://openalex.org/W1536189216","https://openalex.org/W1595924202","https://openalex.org/W1821438013","https://openalex.org/W1838641826","https://openalex.org/W1862517694","https://openalex.org/W1887863677","https://openalex.org/W1896861650","https://openalex.org/W1920035725","https://openalex.org/W1930895125","https://openalex.org/W1940732706","https://openalex.org/W1944430150","https://openalex.org/W1953387859","https://openalex.org/W1965542498","https://openalex.org/W1965769627","https://openalex.org/W1966763079","https://openalex.org/W1970593462","https://openalex.org/W1977546984","https://openalex.org/W1980035039","https://openalex.org/W1984258977","https://openalex.org/W1989771063","https://openalex.org/W1992750424","https://openalex.org/W1995007817","https://openalex.org/W1995473821","https://openalex.org/W2004681740","https://openalex.org/W2005688611","https://openalex.org/W2005733409","https://openalex.org/W2005753411","https://openalex.org/W2007102329","https://openalex.org/W2010002712","https://openalex.org/W2010729137","https://openalex.org/W2012808596","https://openalex.org/W2016822528","https://openalex.org/W2016833582","https://openalex.org/W2017265604","https://openalex.org/W2018374431","https://openalex.org/W2021422854","https://openalex.org/W2024777863","https://openalex.org/W2024893955","https://openalex.org/W2028579560","https://openalex.org/W2032519529","https://openalex.org/W2034115389","https://openalex.org/W2035309334","https://openalex.org/W2040730344","https://openalex.org/W2043587224","https://openalex.org/W2047657755","https://openalex.org/W2049552282","https://openalex.org/W2052739233","https://openalex.org/W2052816946","https://openalex.org/W2052925094","https://openalex.org/W2053852136","https://openalex.org/W2056667876","https://openalex.org/W2058713665","https://openalex.org/W2060440673","https://openalex.org/W2060876075","https://openalex.org/W2066868518","https://openalex.org/W2067585473","https://openalex.org/W2068619849","https://openalex.org/W2074521332","https://openalex.org/W2080828049","https://openalex.org/W2084089666","https://openalex.org/W2084612827","https://openalex.org/W2086930991","https://openalex.org/W2090181358","https://openalex.org/W2092979043","https://openalex.org/W2096489857","https://openalex.org/W2097682287","https://openalex.org/W2103347449","https://openalex.org/W2104165703","https://openalex.org/W2105435030","https://openalex.org/W2105746514","https://openalex.org/W2106275447","https://openalex.org/W2108008366","https://openalex.org/W2113477288","https://openalex.org/W2113512182","https://openalex.org/W2114064238","https://openalex.org/W2117623554","https://openalex.org/W2117823975","https://openalex.org/W2127153931","https://openalex.org/W2134118606","https://openalex.org/W2137365058","https://openalex.org/W2140819149","https://openalex.org/W2145662640","https://openalex.org/W2146375276","https://openalex.org/W2146762986","https://openalex.org/W2149159124","https://openalex.org/W2156840245","https://openalex.org/W2156945455","https://openalex.org/W2163219205","https://openalex.org/W2166295047","https://openalex.org/W2169732420","https://openalex.org/W2397445751","https://openalex.org/W2477239645","https://openalex.org/W4234454654"],"related_works":["https://openalex.org/W1965542498","https://openalex.org/W4320480672","https://openalex.org/W4387336535","https://openalex.org/W3155294922","https://openalex.org/W2056941308","https://openalex.org/W2113512182","https://openalex.org/W2287087024","https://openalex.org/W2963835773","https://openalex.org/W2769812725","https://openalex.org/W4412099903"],"abstract_inverted_index":{"Acute":[0],"lymphoblastic":[1],"leukemia":[2],"(ALL)":[3],"is":[4,21,130,166],"a":[5,88,117,142,149,212],"hematologic":[6],"malignancy":[7],"that":[8,86,180,223],"predominantly":[9],"occurs":[10],"in":[11,39,44,79],"children":[12,45],"between":[13],"2":[14],"and":[15,31,55,63,107,173,193],"10":[16],"years":[17,62],"of":[18,25,92,102,109,139,186,226],"age.":[19],"L-asparaginase":[20],"an":[22,153],"integral":[23],"component":[24],"treatment":[26,37,159],"for":[27,53],"patients":[28,81,140,194,207],"with":[29,65,160,181],"ALL":[30],"since":[32],"its":[33],"introduction":[34],"into":[35],"pediatric":[36],"protocols":[38,85],"the":[40,99,105,126],"1960s,":[41],"survival":[42,78],"rates":[43],"have":[46,67,178],"progressively":[47],"risen":[48],"to":[49,137,152,196,200,206,221],"nearly":[50],"90%.":[51],"Outcomes":[52],"adolescent":[54],"young":[56],"adult":[57],"(AYA)":[58],"patients,":[59],"aged":[60],"15-39":[61],"diagnosed":[64],"ALL,":[66],"historically":[68],"been":[69],"less":[70],"favorable.":[71],"However,":[72],"recent":[73],"reports":[74],"suggest":[75],"substantially":[76],"increased":[77],"AYA":[80],"treated":[82],"on":[83],"pediatric-inspired":[84],"include":[87],"greater":[89],"cumulative":[90],"dose":[91],"asparaginase.":[93,163],"All":[94],"currently":[95],"available":[96],"asparaginases":[97,172],"share":[98],"same":[100],"mechanism":[101],"action":[103],"-":[104,113],"deamination":[106],"depletion":[108],"serum":[110],"asparagine":[111],"levels":[112,185,225],"yet":[114],"each":[115],"displays":[116],"markedly":[118],"different":[119],"pharmacokinetic":[120],"profile.":[121],"Pegylated":[122],"asparaginase":[123,156,165,188,198,227],"derived":[124],"from":[125,169],"bacterium":[127],"Escherichia":[128],"coli":[129],"used":[131],"as":[132],"first-line":[133],"therapy;":[134],"however,":[135],"up":[136],"30%":[138],"develop":[141],"treatment-limiting":[143],"hypersensitivity":[144,150,201,213],"reaction.":[145,214],"Patients":[146],"who":[147,208],"experience":[148,211],"reaction":[151],"E.":[154,170],"coli-derived":[155,171],"can":[157,190,202],"continue":[158],"Erwinia":[161,164,187,197],"chrysanthemi":[162],"immunologically":[167],"distinct":[168],"exhibits":[174],"no":[175],"cross-reactivity.":[176],"Studies":[177],"shown":[179],"adequate":[182],"dosing,":[183],"therapeutic":[184,224],"activity":[189,228],"be":[191,219],"achieved,":[192],"switched":[195],"due":[199],"obtain":[203],"outcomes":[204],"similar":[205],"do":[209],"not":[210],"Therapeutic":[215],"drug":[216],"monitoring":[217],"may":[218],"required":[220],"ensure":[222],"are":[229],"maintained.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":29},{"year":2024,"cited_by_count":46},{"year":2023,"cited_by_count":49},{"year":2022,"cited_by_count":37},{"year":2021,"cited_by_count":59},{"year":2020,"cited_by_count":36},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-07-22T00:00:00"}
