{"id":"https://openalex.org/W2471255554","doi":"https://doi.org/10.5740/jaoacint.16-0082","title":"Chemometrics Tools in Detection and Quantitation of the Main Impurities Present in Aspirin/Dipyridamole Extended-Release Capsules","display_name":"Chemometrics Tools in Detection and Quantitation of the Main Impurities Present in Aspirin/Dipyridamole Extended-Release Capsules","publication_year":2016,"publication_date":"2016-06-15","ids":{"openalex":"https://openalex.org/W2471255554","doi":"https://doi.org/10.5740/jaoacint.16-0082","mag":"2471255554","pmid":"https://pubmed.ncbi.nlm.nih.gov/27302874"},"language":"en","primary_location":{"id":"doi:10.5740/jaoacint.16-0082","doi":"https://doi.org/10.5740/jaoacint.16-0082","is_oa":false,"landing_page_url":"https://doi.org/10.5740/jaoacint.16-0082","pdf_url":null,"source":{"id":"https://openalex.org/S103486911","display_name":"Journal of AOAC International","issn_l":"1060-3271","issn":["1060-3271","1944-7922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of AOAC INTERNATIONAL","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108896279","display_name":"Nariman A. El\u2010Ragehy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nariman A El-Ragehy","raw_affiliation_strings":["Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr el Aini St, 11562 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr el Aini St, 11562 Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030036948","display_name":"Ali M. Yehia","orcid":"https://orcid.org/0000-0003-4942-1474","observed_orcids":["https://orcid.org/0000-0003-4942-1474"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ali M Yehia","raw_affiliation_strings":["Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr el Aini St, 11562 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr el Aini St, 11562 Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061398443","display_name":"Nagiba Yehia Hassan","orcid":"https://orcid.org/0000-0003-3311-8841","observed_orcids":["https://orcid.org/0000-0003-3311-8841"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nagiba Y Hassan","raw_affiliation_strings":["Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr el Aini St, 11562 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr el Aini St, 11562 Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011360052","display_name":"Mahmoud A. Tantawy","orcid":"https://orcid.org/0000-0003-3756-8065","observed_orcids":["https://orcid.org/0000-0003-3756-8065"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Mahmoud A Tantawy","raw_affiliation_strings":["Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr el Aini St, 11562 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr el Aini St, 11562 Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032574431","display_name":"Mohamed A. A. Abdelkawy","orcid":"https://orcid.org/0000-0002-9043-9644","observed_orcids":["https://orcid.org/0000-0002-9043-9644"]},"institutions":[{"id":"https://openalex.org/I186217134","display_name":"Future University in Egypt","ror":"https://ror.org/03s8c2x09","country_code":"EG","type":"education","lineage":["https://openalex.org/I186217134"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed Abdelkawy","raw_affiliation_strings":["Future University, Faculty of Pharmacy, Analytical Chemistry Department, End of 90th St, Fifth Settlement, New Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Future University, Faculty of Pharmacy, Analytical Chemistry Department, End of 90th St, Fifth Settlement, New Cairo, Egypt","institution_ids":["https://openalex.org/I186217134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011360052"],"corresponding_institution_ids":["https://openalex.org/I145487455"],"apc_list":{"value":1868,"currency":"USD","value_usd":1868},"apc_paid":null,"fwci":0.1747,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.46008829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"99","issue":"4","first_page":"948","last_page":"956"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.1996999979019165,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12878","display_name":"Pharmaceutical Quality and Counterfeiting","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dipyridamole","display_name":"dipyridamole","score":1.0},{"id":"https://openalex.org/keywords/extended-release-capsules","display_name":"extended-release capsules","score":0.8360000252723694},{"id":"https://openalex.org/keywords/impurity-detection","display_name":"impurity detection","score":0.8009999990463257},{"id":"https://openalex.org/keywords/salicylic-acid","display_name":"salicylic acid","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tartaric-acid","display_name":"tartaric acid","score":0.8330000042915344},{"id":"https://openalex.org/keywords/uv-spectrophotometry","display_name":"UV spectrophotometry","score":0.7519999742507935},{"id":"https://openalex.org/keywords/partial-least-squares","display_name":"partial least squares","score":0.8299999833106995},{"id":"https://openalex.org/keywords/multivariate-curve-resolution","display_name":"multivariate curve resolution","score":0.9020000100135803},{"id":"https://openalex.org/keywords/neural-network","display_name":"artificial neural networks","score":0.8889999985694885},{"id":"https://openalex.org/keywords/multivariate-calibration","display_name":"multivariate calibration","score":0.8109999895095825},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.38600000739097595},{"id":"https://openalex.org/keywords/secondary-stroke-prevention","display_name":"secondary stroke prevention","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C151304367","wikidata":"https://www.wikidata.org/wiki/Q910067","display_name":"Chemometrics","level":2,"score":0.742015540599823},{"id":"https://openalex.org/C22354355","wikidata":"https://www.wikidata.org/wiki/Q422009","display_name":"Partial least squares regression","level":2,"score":0.7162226438522339},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.6124157905578613},{"id":"https://openalex.org/C2778221352","wikidata":"https://www.wikidata.org/wiki/Q193572","display_name":"Salicylic acid","level":2,"score":0.5614486932754517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5145189166069031},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.504892885684967},{"id":"https://openalex.org/C9936470","wikidata":"https://www.wikidata.org/wiki/Q6510405","display_name":"Least-squares function approximation","level":3,"score":0.5040280222892761},{"id":"https://openalex.org/C2776890861","wikidata":"https://www.wikidata.org/wiki/Q419374","display_name":"Dipyridamole","level":2,"score":0.49466535449028015},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.4728807806968689},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.4695834517478943},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.43976378440856934},{"id":"https://openalex.org/C71987851","wikidata":"https://www.wikidata.org/wiki/Q7216430","display_name":"Impurity","level":2,"score":0.4376077950000763},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.37739861011505127},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3299976587295532},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.22092264890670776},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16806378960609436},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11827567219734192},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07157805562019348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06829145550727844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06280282139778137},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068342","descriptor_name":"Aspirin, Dipyridamole Drug Combination","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004176","descriptor_name":"Dipyridamole","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004176","descriptor_name":"Dipyridamole","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004176","descriptor_name":"Dipyridamole","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004340","descriptor_name":"Drug Contamination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013644","descriptor_name":"Tartrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013644","descriptor_name":"Tartrates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5740/jaoacint.16-0082","doi":"https://doi.org/10.5740/jaoacint.16-0082","is_oa":false,"landing_page_url":"https://doi.org/10.5740/jaoacint.16-0082","pdf_url":null,"source":{"id":"https://openalex.org/S103486911","display_name":"Journal of AOAC International","issn_l":"1060-3271","issn":["1060-3271","1944-7922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of AOAC INTERNATIONAL","raw_type":"journal-article"},{"id":"pmid:27302874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27302874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of AOAC International","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2799675651","https://openalex.org/W2460909534","https://openalex.org/W4413416729","https://openalex.org/W3198270519","https://openalex.org/W1972113127","https://openalex.org/W2386538284","https://openalex.org/W2061855675","https://openalex.org/W1578685315","https://openalex.org/W2590233708","https://openalex.org/W3188427427"],"abstract_inverted_index":{"Aspirin":[0],"(ASP)":[1],"and":[2,18,30,86,92,113,125,138,200],"dipyridamole":[3],"(DIP)":[4],"in":[5,10,54,191],"combination":[6],"is":[7,24,61],"widely":[8],"used":[9,130],"the":[11,31,41,51,55,99,123,133,146,150,167,180,192,198],"prevention":[12],"of":[13,28,50,57,97,111,116,136,179,188],"secondary":[14],"events":[15],"after":[16],"stroke":[17],"transient":[19],"ischemic":[20],"attack.":[21],"Salicylic":[22],"acid":[23],"a":[25,186],"well-known":[26],"impurity":[27],"ASP,":[29],"DIP":[32,189],"extended-release":[33,168,193],"formulation":[34,169],"may":[35],"contain":[36],"ester":[37],"impurities":[38,60],"originating":[39],"from":[40],"reaction":[42],"with":[43],"tartaric":[44],"acid.":[45],"UV":[46],"spectral":[47,127],"data":[48],"analysis":[49,135,178],"active":[52],"ingredients":[53],"presence":[56],"their":[58],"main":[59],"presented":[62],"using":[63,155],"multivariate":[64,79,159],"approaches.":[65],"Four":[66],"chemometric-assisted":[67],"spectrophotometric":[68],"methods,":[69],"namely,":[70],"partial":[71],"least-squares,":[72],"concentration":[73],"residuals":[74],"augmented":[75],"classical":[76],"least-squares":[77,84],"(CRACLS),":[78],"curve":[80],"resolution":[81],"(MCR)":[82],"alternating":[83],"(ALS),":[85],"artificial":[87],"neural":[88],"networks,":[89],"were":[90,102,129,174],"developed":[91],"validated.":[93],"The":[94,140,157,171],"quantitative":[95],"analyses":[96],"all":[98],"proposed":[100,199],"calibrations":[101],"compared":[103],"by":[104,145,177],"percentage":[105],"recoveries,":[106],"root":[107],"mean":[108],"square":[109],"error":[110,115,142],"prediction,":[112],"standard":[114],"prediction.":[117],"In":[118],"addition,":[119],"r(2)":[120],"values":[121],"between":[122,197],"pure":[124],"estimated":[126],"profiles":[128],"to":[131],"evaluate":[132],"qualitative":[134],"CRACLS":[137,147],"MCR-ALS.":[139,156],"lowest":[141],"was":[143,153],"obtained":[144],"model,":[148],"whereas":[149],"best":[151],"correlation":[152],"achieved":[154],"four":[158],"calibration":[160],"methods":[161,202],"could":[162],"successfully":[163],"be":[164],"applied":[165],"for":[166],"analysis.":[170],"application":[172],"results":[173],"also":[175],"validated":[176],"stored":[181],"dosage-form":[182],"solution,":[183],"which":[184],"showed":[185,203],"susceptibility":[187],"esterification":[190],"formulation.":[194],"Statistical":[195],"comparison":[196],"official":[201],"no":[204],"significant":[205],"difference.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-07-22T00:00:00"}
