{"id":"https://openalex.org/W2471003218","doi":"https://doi.org/10.1182/blood.v126.23.5317.5317","title":"Thrombotic Microangiopathy in Multiple Myeloma","display_name":"Thrombotic Microangiopathy in Multiple Myeloma","publication_year":2015,"publication_date":"2015-12-03","ids":{"openalex":"https://openalex.org/W2471003218","doi":"https://doi.org/10.1182/blood.v126.23.5317.5317","mag":"2471003218"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v126.23.5317.5317","doi":"https://doi.org/10.1182/blood.v126.23.5317.5317","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.5317.5317","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082304508","display_name":"Jennifer C. Yui","orcid":"https://orcid.org/0000-0003-2375-9530","observed_orcids":["https://orcid.org/0000-0003-2375-9530"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Yui","raw_affiliation_strings":["Department of Internal Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001743308","display_name":"Jan M. Van Keer","orcid":"https://orcid.org/0000-0003-4490-5170","observed_orcids":["https://orcid.org/0000-0003-4490-5170"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Van Keer","raw_affiliation_strings":["UZ Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UZ Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026151069","display_name":"Ravi Vij","orcid":"https://orcid.org/0000-0001-8795-3610","observed_orcids":["https://orcid.org/0000-0001-8795-3610"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Vij","raw_affiliation_strings":["Washington University, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018399640","display_name":"Kenar D. Jhaveri","orcid":"https://orcid.org/0000-0003-1578-0524","observed_orcids":["https://orcid.org/0000-0003-1578-0524"]},"institutions":[{"id":"https://openalex.org/I2800496781","display_name":"North Shore University Hospital","ror":"https://ror.org/05m8d2x46","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800496781"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenar Jhaveri","raw_affiliation_strings":["Division of Kidney Diseases and Hypertension, North Shore University Hospital, Great Neck, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Kidney Diseases and Hypertension, North Shore University Hospital, Great Neck, NY","institution_ids":["https://openalex.org/I2800496781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018522443","display_name":"Efstathios Kastritis","orcid":"https://orcid.org/0000-0001-8191-5832","observed_orcids":["https://orcid.org/0000-0001-8191-5832"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Efstathios Kastritis","raw_affiliation_strings":["Department of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012403700","display_name":"Francis K. Buadi","orcid":"https://orcid.org/0000-0003-3214-0203","observed_orcids":["https://orcid.org/0000-0003-3214-0203"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis Buadi","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000308170","display_name":"Angela A. Dispenzieri","orcid":"https://orcid.org/0000-0001-8780-9512","observed_orcids":["https://orcid.org/0000-0001-8780-9512"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Dispenzieri","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007747233","display_name":"David Dingli","orcid":"https://orcid.org/0000-0001-7477-3004","observed_orcids":["https://orcid.org/0000-0001-7477-3004"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Dingli","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051470930","display_name":"Stephen J. Russell","orcid":"https://orcid.org/0009-0007-8925-5163","observed_orcids":["https://orcid.org/0009-0007-8925-5163","https://orcid.org/0000-0002-0799-6432"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Russell","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016853434","display_name":"Nelson Leung","orcid":"https://orcid.org/0000-0002-5651-1411","observed_orcids":["https://orcid.org/0000-0002-5651-1411"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nelson Leung","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN","Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.4915,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66880414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"126","issue":"23","first_page":"5317","last_page":"5317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.12520000338554382,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombotic-microangiopathy","display_name":"thrombotic microangiopathy","score":1.0},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/carfilzomib","display_name":"carfilzomib","score":1.0},{"id":"https://openalex.org/keywords/drug-induced-thrombosis","display_name":"drug-induced thrombosis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/microangiopathic-hemolytic-anemia","display_name":"microangiopathic hemolytic anemia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/free-light-chains","display_name":"free light chains","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.699999988079071},{"id":"https://openalex.org/keywords/drug-withdrawal","display_name":"drug withdrawal","score":0.47600001096725464},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2777878052","wikidata":"https://www.wikidata.org/wiki/Q3312044","display_name":"Thrombotic microangiopathy","level":3,"score":0.8956990242004395},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.8137662410736084},{"id":"https://openalex.org/C2781127562","wikidata":"https://www.wikidata.org/wiki/Q2063651","display_name":"Microangiopathic hemolytic anemia","level":4,"score":0.7875604629516602},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7870043516159058},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6668602228164673},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5915135741233826},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5383172631263733},{"id":"https://openalex.org/C2780921031","wikidata":"https://www.wikidata.org/wiki/Q14873945","display_name":"ADAMTS13","level":4,"score":0.44573497772216797},{"id":"https://openalex.org/C2780108899","wikidata":"https://www.wikidata.org/wiki/Q15366934","display_name":"Carfilzomib","level":4,"score":0.4340100586414337},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.43387770652770996},{"id":"https://openalex.org/C2778585876","wikidata":"https://www.wikidata.org/wiki/Q1426491","display_name":"Thrombotic thrombocytopenic purpura","level":3,"score":0.34517061710357666},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32688701152801514},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16490274667739868},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.07669815421104431}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v126.23.5317.5317","doi":"https://doi.org/10.1182/blood.v126.23.5317.5317","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.5317.5317","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3023957398","https://openalex.org/W2965330292","https://openalex.org/W2964371740","https://openalex.org/W2416137380","https://openalex.org/W2954712783","https://openalex.org/W7160632409","https://openalex.org/W2405131508","https://openalex.org/W2998682497","https://openalex.org/W2588788184","https://openalex.org/W4381164863"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Thrombotic":[2],"microangiopathy":[3],"(TMA)":[4],"is":[5,24,32,380],"a":[6,132,138,143,178,187,345,355],"hematologic":[7],"syndrome":[8],"associated":[9,26,46,65,316],"with":[10,27,45,66,77,99,116,137,142,164,221,239,301,317,340],"endothelial":[11],"injury,":[12],"microvascular":[13],"thrombosis,":[14],"and":[15,31,51,90,170,223,253,272,299,333,351,372],"hemolytic":[16,94],"anemia":[17,371],"resulting":[18],"in":[19,35,61,75,146,189,268,278],"end":[20],"organ":[21],"damage.":[22],"TMA":[23,60,82,106,117,139,188,199,211,238,246,329,339,360,379],"rarely":[25],"multiple":[28,73],"myeloma":[29],"(MM)":[30],"usually":[33],"reported":[34],"the":[36,86,108,119,190,195,198,204,210,231,248,269,282,294,304,308,324,334,349,352],"setting":[37,191],"of":[38,59,80,88,92,110,121,192,230,237,251,281,284,290,297,303,310,319,328,336,338,342],"allogeneic":[39],"hematopoietic":[40],"stem":[41],"cell":[42],"transplants":[43],"(AHSCT),":[44],"graft":[47],"versus":[48],"host":[49],"disease":[50],"calcineurin":[52],"inhibitor":[53],"use.":[54],"We":[55],"present":[56],"11":[57],"cases":[58,153,236],"MM":[62,100,122,279,298],"patients":[63,76,98,114,160,166,172,244,255,265,364],"not":[64],"AHSCT.":[67,285],"Methods:":[68],"Cases":[69],"were":[70,101,256,293],"collected":[71],"from":[72],"centers":[74],"confirmed":[78],"diagnosis":[79],"MM.":[81,240,305],"was":[83,218],"diagnosed":[84],"by":[85],"presence":[87],"thrombocytopenia":[89],"evidence":[91],"microangiopathic":[93],"anemia.":[95],"Results:":[96],"Eleven":[97],"identified":[102],"to":[103,135,185,314],"have":[104],"developed":[105,200,225],"during":[107,155],"course":[109],"their":[111],"disease.":[112],"Two":[113],"presented":[115],"at":[118],"time":[120],"diagnosis.":[123],"A":[124,228],"third":[125,289],"had":[126,181,245],"been":[127,182],"off":[128],"treatment":[129,302],"for":[130,359,363],"over":[131],"year":[133],"prior":[134,184],"presenting":[136],"which":[140],"correlated":[141],"significant":[144],"increase":[145],"her":[147],"free":[148],"light":[149],"chains.":[150],"The":[151],"other":[152],"occurred":[154],"active":[156],"treatment.":[157],"All":[158],"remaining":[159,196],"received":[161],"proteasome":[162,205,311,366],"inhibitors,":[163],"three":[165],"on":[167,173,177,257,365],"bortezomib-based":[168,179,261],"regimens":[169],"five":[171],"carfilzomib.":[174],"One":[175,216],"patient":[176,217],"regimen":[180],"stable":[183],"developing":[186],"sepsis.":[193],"In":[194,207,286,306,321],"patients,":[197,291],"rapidly":[201],"after":[202,213,330],"initiating":[203],"inhibitor.":[206],"all":[208],"cases,":[209,323],"improved":[212,300],"drug":[214],"withdrawal.":[215],"later":[219],"rechallenged":[220],"bortezomib":[222],"again":[224],"TMA.":[226,320,353],"Discussion:":[227],"review":[229],"literature":[232,270],"reveals":[233],"only":[234],"nine":[235],"Of":[241],"these,":[242],"4":[243],"as":[247],"initial":[249,295],"presentation":[250,296],"MM,":[252],"5":[254],"treatment,":[258],"most":[259],"often":[260],"regimens.":[262],"Our":[263],"series":[264],"match":[266],"those":[267],"closely":[271],"demonstrate":[273],"that":[274],"TMAs":[275,292],"can":[276],"occur":[277],"outside":[280],"context":[283],"roughly":[287],"one":[288],"others,":[307],"use":[309],"inhibitors":[312,367],"appears":[313],"be":[315,376],"development":[318],"these":[322],"temporal":[325],"correlation,":[326],"resolution":[327],"medication":[331,350],"withdrawal,":[332],"instance":[335],"recurrence":[337],"rechallenge":[341],"bortezomib,":[343],"support":[344],"causal":[346],"relationship":[347],"between":[348],"Thus,":[354],"high":[356],"clinical":[357],"suspicion":[358],"must":[361],"exist":[362],"who":[368],"develop":[369],"worsening":[370],"thrombocytopenia.":[373],"Medication":[374],"should":[375],"withdrawn":[377],"if":[378],"diagnosed.":[381],"Disclosures":[382],"Vij:":[383],"Onyx:":[384],"Consultancy,":[385,396,405],"Honoraria,":[386,392,397],"Research":[387,398,406],"Funding,":[388,399],"Speakers":[389,393,400],"Bureau;":[390,394,401],"Millennium:":[391],"Celgene:":[395],"BMS:":[402],"Consultancy;":[403,409,411,413],"Takeda:":[404],"Funding;":[407],"Novartis:":[408],"Sanofi:":[410],"Janssen:":[412],"Merck:":[414],"Consultancy.":[415]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-07-22T00:00:00"}
