{"id":"https://openalex.org/W2470842467","doi":"https://doi.org/10.3390/molecules21060818","title":"Anti-Inflammatory Effects of Melandrii Herba Ethanol Extract via Inhibition of NF-\u03baB and MAPK Signaling Pathways and Induction of HO-1 in RAW 264.7 Cells and Mouse Primary Macrophages","display_name":"Anti-Inflammatory Effects of Melandrii Herba Ethanol Extract via Inhibition of NF-\u03baB and MAPK Signaling Pathways and Induction of HO-1 in RAW 264.7 Cells and Mouse Primary Macrophages","publication_year":2016,"publication_date":"2016-06-22","ids":{"openalex":"https://openalex.org/W2470842467","doi":"https://doi.org/10.3390/molecules21060818","mag":"2470842467","pmid":"https://pubmed.ncbi.nlm.nih.gov/27338335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6272949"},"language":"en","primary_location":{"id":"doi:10.3390/molecules21060818","doi":"https://doi.org/10.3390/molecules21060818","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules21060818","pdf_url":"https://www.mdpi.com/1420-3049/21/6/818/pdf?version=1466590044","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/21/6/818/pdf?version=1466590044","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003882041","display_name":"Yun Hee Jeong","orcid":"https://orcid.org/0000-0002-5144-1151","observed_orcids":["https://orcid.org/0000-0002-5144-1151"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun Jeong","raw_affiliation_strings":["Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Korea","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065716871","display_name":"You-Chang Oh","orcid":"https://orcid.org/0000-0002-9889-7770","observed_orcids":["https://orcid.org/0000-0002-9889-7770"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"You-Chang Oh","raw_affiliation_strings":["Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Korea","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102887329","display_name":"Won\u2010Kyung Cho","orcid":"https://orcid.org/0000-0001-6425-5748","observed_orcids":["https://orcid.org/0000-0001-6425-5748"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won-Kyung Cho","raw_affiliation_strings":["Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Korea","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078384578","display_name":"Bohyoung Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bohyoung Lee","raw_affiliation_strings":["Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Korea","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100958878","display_name":"Jin Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jin Ma","raw_affiliation_strings":["Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Korea","institution_ids":["https://openalex.org/I4210087584"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100958878"],"corresponding_institution_ids":["https://openalex.org/I4210087584"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":5.4708,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.94041204,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"21","issue":"6","first_page":"818","last_page":"818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.6675000190734863,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.6675000190734863,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.20730000734329224,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.0689999982714653,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8489999771118164},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9769999980926514},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.5040000081062317},{"id":"https://openalex.org/keywords/oriental-medicine","display_name":"oriental medicine","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7279550433158875},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.6265043020248413},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6063780188560486},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.5740674138069153},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5556024312973022},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5498901009559631},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5235645174980164},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5169584155082703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.50046706199646},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.4854219853878021},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4370706379413605},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4359610974788666},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42676621675491333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3198939859867096},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2669277489185333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22107678651809692},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17543280124664307},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.079316645860672},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/molecules21060818","doi":"https://doi.org/10.3390/molecules21060818","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules21060818","pdf_url":"https://www.mdpi.com/1420-3049/21/6/818/pdf?version=1466590044","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5277327","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6272949","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6272949","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6272949","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:27338335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27338335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:606fc9cadd794b9c8046d46dbf9622a5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/606fc9cadd794b9c8046d46dbf9622a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 21, Iss 6, p 818 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules21060818","doi":"https://doi.org/10.3390/molecules21060818","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules21060818","pdf_url":"https://www.mdpi.com/1420-3049/21/6/818/pdf?version=1466590044","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6417915635","display_name":null,"funder_award_id":"K16281","funder_id":"https://openalex.org/F4320322113","funder_display_name":"Korea Institute of Oriental Medicine"}],"funders":[{"id":"https://openalex.org/F4320322113","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2470842467.pdf","grobid_xml":"https://content.openalex.org/works/W2470842467.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W319674832","https://openalex.org/W1549679997","https://openalex.org/W1589703926","https://openalex.org/W1874548252","https://openalex.org/W1964159726","https://openalex.org/W1975012398","https://openalex.org/W1976326847","https://openalex.org/W1986526737","https://openalex.org/W1987217810","https://openalex.org/W1990065094","https://openalex.org/W1992361007","https://openalex.org/W1996095483","https://openalex.org/W1997298137","https://openalex.org/W1999851046","https://openalex.org/W2002851339","https://openalex.org/W2002926183","https://openalex.org/W2005587841","https://openalex.org/W2012660332","https://openalex.org/W2013128540","https://openalex.org/W2028382049","https://openalex.org/W2028437343","https://openalex.org/W2038197749","https://openalex.org/W2039375190","https://openalex.org/W2040470926","https://openalex.org/W2044833301","https://openalex.org/W2057069641","https://openalex.org/W2058714321","https://openalex.org/W2059983531","https://openalex.org/W2064711537","https://openalex.org/W2070118415","https://openalex.org/W2072465736","https://openalex.org/W2077941055","https://openalex.org/W2085503736","https://openalex.org/W2085851186","https://openalex.org/W2087448081","https://openalex.org/W2088419278","https://openalex.org/W2090155698","https://openalex.org/W2099951919","https://openalex.org/W2121000910","https://openalex.org/W2121652706","https://openalex.org/W2124029073","https://openalex.org/W2129352413","https://openalex.org/W2133416335","https://openalex.org/W2133801172","https://openalex.org/W2133984874","https://openalex.org/W2134062610","https://openalex.org/W2138992293","https://openalex.org/W2140677435","https://openalex.org/W2149395040","https://openalex.org/W2159087408","https://openalex.org/W2322559033","https://openalex.org/W2331176038","https://openalex.org/W2371408814","https://openalex.org/W2401155949","https://openalex.org/W4252406065"],"related_works":["https://openalex.org/W1892620062","https://openalex.org/W2085465824","https://openalex.org/W3127757727","https://openalex.org/W7166700807","https://openalex.org/W3208870460","https://openalex.org/W2065528712","https://openalex.org/W2167716767","https://openalex.org/W1965846477","https://openalex.org/W2477700080","https://openalex.org/W1547158781"],"abstract_inverted_index":{"Melandrii":[0],"Herba":[1],"(MH)":[2],"is":[3],"a":[4,64,210],"traditional":[5],"Asian":[6],"medicinal":[7],"herb":[8],"used":[9],"to":[10,37],"treat":[11],"breast":[12],"cancer,":[13],"anuria,":[14],"and":[15,23,42,81,84,95,108,127,133,146,156,182,187],"diseases":[16],"of":[17,33,46,72,77,125,154,189,201],"lactation.":[18],"However,":[19],"its":[20],"biological":[21],"properties":[22],"molecular":[24,44],"mechanisms":[25],"have":[26],"not":[27],"been":[28],"fully":[29],"elucidated.":[30],"The":[31,70,167],"purpose":[32],"this":[34],"study":[35],"was":[36,61],"investigate":[38],"the":[39,52,75,89,123,151,198],"anti-inflammatory":[40,173],"activity":[41],"underlying":[43],"mechanism":[45],"MH":[47],"ethanol":[48],"extract":[49],"(MHE)":[50],"on":[51,74],"lipopolysaccharide":[53],"(LPS)-mediated":[54],"inflammatory":[55,79,128,177,205],"response":[56],"in":[57,135,164,192],"macrophages.":[58,166,193],"MHE":[59,73,119,141,163,171,202],"cytotoxicity":[60],"determined":[62,87],"using":[63,88,112],"cell":[65],"counting":[66],"kit":[67],"(CCK)":[68],"assay.":[69],"effects":[71,174],"production":[76,179],"NO,":[78],"cytokines,":[80,129],"related":[82],"proteins":[83],"mRNAs":[85],"were":[86,110,159],"Griess":[90],"test,":[91],"ELISA,":[92],"Western":[93,113],"blotting,":[94],"real-time":[96],"RT-PCR,":[97],"respectively.":[98],"In":[99],"addition,":[100],"intracellular":[101],"signaling":[102,184],"pathways,":[103],"such":[104],"as":[105,203],"NF-\u03baB,":[106],"MAPK,":[107],"HO-1,":[109],"analyzed":[111],"blotting.":[114],"Our":[115],"results":[116,168,196],"revealed":[117],"that":[118,170],"treatment":[120,142],"significantly":[121,160],"inhibited":[122,143],"secretion":[124],"NO":[126],"including":[130],"TNF-\u03b1,":[131],"IL-6,":[132],"IL-1\u03b2":[134],"macrophages,":[136],"at":[137],"sub-cytotoxic":[138],"concentrations.":[139],"Furthermore,":[140],"iNOS":[144],"expression":[145,191],"induced":[147],"HO-1":[148,190],"expression.":[149],"Finally,":[150],"transcriptional":[152],"activities":[153],"NF-\u03baB":[155,181],"MAPK":[157,183],"activation":[158],"suppressed":[161],"by":[162,175],"LPS-stimulated":[165],"indicate":[169],"exerts":[172],"suppressing":[176],"mediator":[178],"via":[180],"pathways":[185],"inhibition":[186],"induction":[188],"Therefore,":[194],"our":[195],"suggest":[197],"potential":[199],"value":[200],"an":[204],"therapeutic":[206],"agent":[207],"developed":[208],"from":[209],"natural":[211],"substance.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
