{"id":"https://openalex.org/W2470180731","doi":null,"title":"Extracellular deposition of eosinophil and neutrophil granule proteins in the IgE-mediated cutaneous late phase reaction.","display_name":"Extracellular deposition of eosinophil and neutrophil granule proteins in the IgE-mediated cutaneous late phase reaction.","publication_year":1990,"publication_date":"1990-05-01","ids":{"openalex":"https://openalex.org/W2470180731","mag":"2470180731","pmid":"https://pubmed.ncbi.nlm.nih.gov/2188046"},"language":"en","primary_location":{"id":"pmid:2188046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2188046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112166192","display_name":"KM Leiferman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K M Leiferman","raw_affiliation_strings":["Department of Dermatology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063906321","display_name":"Takao Fujisawa","orcid":"https://orcid.org/0000-0002-9196-9436","observed_orcids":["https://orcid.org/0000-0002-9196-9436"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Fujisawa","raw_affiliation_strings":["Mayo Clinic Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109319286","display_name":"Gray Bh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B H Gray","raw_affiliation_strings":["Mayo Clinic Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113636261","display_name":"Gerald J. Gleich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G J Gleich","raw_affiliation_strings":["Mayo Clinic Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":2.4436,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.89954148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"62","issue":"5","first_page":"579","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.42989999055862427,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.42989999055862427,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.4196999967098236,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0746999979019165,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-allergy","display_name":"skin allergy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/eosinophil-granule-proteins","display_name":"eosinophil granule proteins","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neutrophil-granule-proteins","display_name":"neutrophil granule proteins","score":0.8880000114440918},{"id":"https://openalex.org/keywords/major-basic-protein","display_name":"major basic protein","score":0.9359999895095825},{"id":"https://openalex.org/keywords/eosinophil-derived-neurotoxin","display_name":"eosinophil-derived neurotoxin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/extracellular-protein-deposition","display_name":"extracellular protein deposition","score":0.8410000205039978},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.6380000114440918},{"id":"https://openalex.org/keywords/passive-sensitization","display_name":"passive sensitization","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.835900604724884},{"id":"https://openalex.org/C60483475","wikidata":"https://www.wikidata.org/wiki/Q1886099","display_name":"Major basic protein","level":4,"score":0.7507994174957275},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.7115718126296997},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.6400364637374878},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5651342272758484},{"id":"https://openalex.org/C88675164","wikidata":"https://www.wikidata.org/wiki/Q22677314","display_name":"Eosinophil cationic protein","level":4,"score":0.5534757971763611},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.5325829982757568},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.53143709897995},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5158114433288574},{"id":"https://openalex.org/C2910475272","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil Granule Proteins","level":5,"score":0.5017216205596924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4673861265182495},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.46705567836761475},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.45320063829421997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31023913621902466},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20870745182037354},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.12970158457756042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09248092770576477},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0922759473323822},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047091","descriptor_name":"Eosinophil Granule Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047208","descriptor_name":"Eosinophil-Derived Neurotoxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2188046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2188046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:2470180731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2188046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2090639986","https://openalex.org/W2056373178","https://openalex.org/W2152617843","https://openalex.org/W1995485487","https://openalex.org/W2140051089","https://openalex.org/W1969132883","https://openalex.org/W2148213909","https://openalex.org/W1970440710","https://openalex.org/W1556246926","https://openalex.org/W2065373406"],"abstract_inverted_index":{"Intradermal":[0],"injection":[1],"of":[2,40,53,92,100,152,205,217,223,229],"allergens":[3],"in":[4,22,47,75,102,120,170,226],"sensitive":[5],"subjects":[6,138],"produces":[7],"an":[8],"IgE-dependent":[9,210],"prolonged":[10],"inflammatory":[11],"reaction,":[12],"the":[13,23,48,118,171,178,206,213,218,227,230],"late":[14],"phase":[15],"reaction":[16],"(LPR).":[17],"Histologically,":[18],"eosinophils":[19,69,165],"are":[20,26,202,209],"present":[21,73],"LPR":[24,49,179,231],"but":[25],"not":[27],"as":[28,30],"numerous":[29],"neutrophils":[31,71],"or":[32,158],"mononuclear":[33],"cells.":[34,86],"We":[35],"determined":[36],"whether":[37],"extracellular":[38,181],"deposition":[39,187],"eosinophil":[41,54,168,182,196],"and":[42,63,70,78,81,95,112,123,135,142,166,183,197,211],"neutrophil":[43,64,184,198],"granule":[44,55,185,199],"proteins":[45],"occurs":[46],"by":[50,149],"immunofluorescent":[51],"localization":[52],"major":[56],"basic":[57],"protein":[58,186,200],"(MBP),":[59],"eosinophil-derived":[60],"neurotoxin":[61],"(EDN),":[62],"elastase.":[65],"Before":[66],"intradermal":[67],"challenge,":[68],"were":[72,83,97,114],"only":[74],"blood":[76],"vessels,":[77],"MBP,":[79,93,110],"EDN,":[80],"elastase":[82,96,113,143,159],"localized":[84],"to":[85,107,130],"At":[87],"15":[88],"minutes,":[89],"small":[90],"amounts":[91],"EDN":[94,111],"found":[98],"outside":[99],"cells":[101],"focal":[103],"areas.":[104],"By":[105],"1":[106],"3":[108],"hours,":[109],"extensively":[115],"deposited":[116],"throughout":[117],"dermis":[119],"a":[121],"granular":[122],"diffuse":[124],"manner;":[125],"these":[126,224],"deposits":[127,201],"persisted":[128],"up":[129],"56":[131],"hours.":[132],"Both":[133],"actively":[134],"passively":[136,147],"sensitized":[137,148],"showed":[139,154,163],"similar":[140],"MBP":[141,157],"deposition.":[144,160],"Skin":[145],"sites":[146],"sera":[150],"depleted":[151],"IgE":[153],"essentially":[155],"no":[156],"Electron":[161],"microscopy":[162],"degenerating":[164],"free":[167],"granules":[169],"dermis.":[172],"Mast":[173],"cell":[174],"numbers":[175],"diminished":[176],"during":[177],"when":[180],"was":[188],"maximal.":[189],"These":[190],"results":[191],"demonstrate":[192],"that":[193],"striking":[194],"dermal":[195],"prominent":[203],"features":[204],"cutaneous":[207],"LPR,":[208],"precede":[212],"maximal":[214],"clinical":[215],"expression":[216],"LPR.":[219],"The":[220],"possible":[221],"significance":[222],"findings":[225],"pathophysiology":[228],"is":[232],"discussed.":[233]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
