{"id":"https://openalex.org/W2470142829","doi":"https://doi.org/10.1227/01.neu.0000489690.06217.d6","title":"120 Effects of Subthalamic Deep Brain Stimulation With Duloxetine on Mechanical and Thermal Thresholds in 6-Hydroxydopamine-Lesioned Rats","display_name":"120 Effects of Subthalamic Deep Brain Stimulation With Duloxetine on Mechanical and Thermal Thresholds in 6-Hydroxydopamine-Lesioned Rats","publication_year":2016,"publication_date":"2016-07-07","ids":{"openalex":"https://openalex.org/W2470142829","doi":"https://doi.org/10.1227/01.neu.0000489690.06217.d6","mag":"2470142829"},"language":"en","primary_location":{"id":"doi:10.1227/01.neu.0000489690.06217.d6","doi":"https://doi.org/10.1227/01.neu.0000489690.06217.d6","is_oa":false,"landing_page_url":"https://doi.org/10.1227/01.neu.0000489690.06217.d6","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050677958","display_name":"Ian Thomas Walling","orcid":"https://orcid.org/0000-0002-2150-2806","observed_orcids":["https://orcid.org/0000-0002-2150-2806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian Thomas Walling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050802615","display_name":"Brian C. Kaszuba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian C. Kaszuba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110889735","display_name":"Lucy E. Gee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucy Gee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050726160","display_name":"Damian Seung-Ho Shin","orcid":"https://orcid.org/0000-0001-7336-7311","observed_orcids":["https://orcid.org/0000-0001-7336-7311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Damian Shin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029140435","display_name":"Julie G. Pilitsis","orcid":"https://orcid.org/0000-0002-6488-9692","observed_orcids":["https://orcid.org/0000-0002-6488-9692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie G. Pilitsis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"63","issue":"Supplement 1","first_page":"150","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subthalamic-nucleus-deep-brain-stimulation","display_name":"subthalamic nucleus deep brain stimulation","score":0.843999981880188},{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.6190000176429749},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mechanical-threshold","display_name":"mechanical threshold","score":0.4950000047683716},{"id":"https://openalex.org/keywords/temperature-thresholds","display_name":"temperature thresholds","score":0.9670000076293945},{"id":"https://openalex.org/keywords/6-ohda-lesion","display_name":"6-hydroxydopamine lesion","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.9649999737739563},{"id":"https://openalex.org/keywords/limb-asymmetry","display_name":"limb asymmetry","score":0.7260000109672546},{"id":"https://openalex.org/keywords/von-frey-filaments","display_name":"von Frey filaments","score":0.8429999947547913},{"id":"https://openalex.org/keywords/randall-selitto-test","display_name":"Randall-Selitto test","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hot-plate-test","display_name":"hot plate test","score":0.8500000238418579},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8575116395950317},{"id":"https://openalex.org/C2780764818","wikidata":"https://www.wikidata.org/wiki/Q411932","display_name":"Duloxetine","level":3,"score":0.7914342284202576},{"id":"https://openalex.org/C2776669363","wikidata":"https://www.wikidata.org/wiki/Q4287680","display_name":"Medial forebrain bundle","level":4,"score":0.7739890813827515},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.6973598003387451},{"id":"https://openalex.org/C2777319143","wikidata":"https://www.wikidata.org/wiki/Q2270424","display_name":"Subthalamic nucleus","level":5,"score":0.6168080568313599},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5181645154953003},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4992849826812744},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.47030729055404663},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.4448874294757843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33949780464172363},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2988593578338623},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.20242702960968018},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1516847312450409},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1227/01.neu.0000489690.06217.d6","doi":"https://doi.org/10.1227/01.neu.0000489690.06217.d6","is_oa":false,"landing_page_url":"https://doi.org/10.1227/01.neu.0000489690.06217.d6","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2539941811","https://openalex.org/W2925060462","https://openalex.org/W2335537991","https://openalex.org/W1488425174","https://openalex.org/W2103677924","https://openalex.org/W2460352110","https://openalex.org/W2510359952","https://openalex.org/W2337634997","https://openalex.org/W1994965203","https://openalex.org/W2313142087"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Chronic":[1],"pain":[2,33],"is":[3],"the":[4,179,200],"most":[5],"reported":[6],"nonmotor":[7],"symptom":[8],"of":[9,32,47,72,141,190],"Parkinson":[10],"Disease":[11],"(PD)":[12],"patients.":[13],"Both":[14],"clinical":[15],"and":[16,22,40,56,98,119,129,132,145,162,178,187,206,254,272,290],"preclinical":[17],"trials":[18],"have":[19,293],"shown":[20],"mechanical":[21,246,300],"thermal":[23,120],"thresholds":[24,220,247,263],"to":[25],"be":[26],"reduced":[27],"with":[28,70,147,154,176,240],"PD.":[29],"The":[30],"mechanisms":[31],"in":[34,74,166,197,218,245,281,298,302],"PD":[35],"are":[36],"not":[37],"fully":[38],"understood,":[39],"patients":[41],"seek":[42],"relief":[43],"through":[44],"a":[45,75,113,167,294],"range":[46],"therapies,":[48],"including":[49],"subthalamic":[50],"deep":[51],"brain":[52],"stimulation":[53,165,224],"(STN":[54],"DBS)":[55],"pharmaceuticals":[57],"such":[58],"as":[59],"gabapentin,":[60],"NSAIDs,":[61],"or":[62],"duloxetine.":[63],"We":[64],"hypothesize":[65],"that":[66],"combining":[67],"STN":[68,100,212,238,255,267,275,291],"DBS":[69,213,239,256,268,276,292],"administration":[71],"duloxetine":[73,241,250],"unilateral":[76,191],"6-hydroxydopamine":[77],"(6OHDA)":[78],"lesion":[79,97],"model":[80],"will":[81],"improve":[82],"thresholds.":[83],"METHODS:":[84],"Male":[85],"Sprague-Dawley":[86],"rats":[87,173],"underwent":[88,138],"craniotomy":[89],"for":[90,183],"simultaneous":[91],"right":[92,99],"6OHDA":[93],"medial":[94],"forebrain":[95],"bundle":[96],"electrode":[101,184],"implantation.":[102],"Parkinsonian":[103],"phenotype":[104],"was":[105,123,150],"determined":[106],"using":[107,125],"80%":[108],"limb":[109,114],"use":[110],"asymmetry":[111,115],"via":[112],"test":[116],"(LAT).":[117],"Mechanical":[118],"threshold":[121,283],"testing":[122,208,227],"performed":[124,151],"vonFrey":[126],"filaments":[127],"(VF)":[128],"Randall-Selitto":[130],"(RS)":[131],"hot":[133,201],"plate":[134,202],"(HPT),":[135],"respectively.":[136],"Animals":[137],"9":[139],"days":[140,228],"testing,":[142,172],"alternating":[143],"VF":[144,219,262,282],"RS":[146],"HPT.":[148],"Testing":[149],"each":[152],"day":[153],"animals":[155],"receiving":[156],"no":[157],"stimulation,":[158,161],"150":[159,222,273],"Hz":[160,164,223,274],"50":[163],"randomized":[168],"order.":[169],"After":[170],"behavioral":[171],"were":[174,181],"perfused":[175],"paraformaldehyde":[177],"brains":[180],"extracted":[182],"placement":[185],"verification":[186],"immunohistochemical":[188],"evaluation":[189],"dopamine":[192],"depletion.":[193],"RESULTS:":[194],"Significant":[195],"improvement":[196,217,244],"time":[198],"on":[199,225],"occurred":[203],"between":[204],"baseline":[205],"on-duloxetine":[207],"(P":[209,251,257],"=":[210,230,233,236,252,258],".0257).":[211],"alone":[214],"showed":[215],"significant":[216,243],"at":[221],"all":[226],"(pDay1":[229],"0.0265,":[231],"pDay2":[232],"0.0002,":[234],"pDay3":[235],"0.0220).":[237],"presented":[242],"vs":[248],"both":[249],".0069)":[253],".0189)":[259],"by":[260],"themselves;":[261],"nearly":[264],"doubled":[265],"from":[266],"alone.":[269,288],"CONCLUSION:":[270],"Duloxetine":[271,289],"combined":[277],"produced":[278],"larger":[279],"increases":[280],"tests":[284],"than":[285],"either":[286],"intervention":[287],"potentially":[295],"additive":[296],"effect":[297],"modulating":[299],"sensitivity":[301],"6OHDA-lesioned":[303],"rats.":[304]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-07-22T00:00:00"}
