{"id":"https://openalex.org/W2470140135","doi":"https://doi.org/10.7554/elife.17063","title":"Crystal structure of an HIV assembly and maturation switch","display_name":"Crystal structure of an HIV assembly and maturation switch","publication_year":2016,"publication_date":"2016-07-14","ids":{"openalex":"https://openalex.org/W2470140135","doi":"https://doi.org/10.7554/elife.17063","mag":"2470140135","pmid":"https://pubmed.ncbi.nlm.nih.gov/27416583","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4946879"},"language":"en","primary_location":{"id":"doi:10.7554/elife.17063","doi":"https://doi.org/10.7554/elife.17063","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.17063","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.17063","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089946534","display_name":"Jonathan M. Wagner","orcid":"https://orcid.org/0000-0001-9161-7222","observed_orcids":["https://orcid.org/0000-0001-9161-7222"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M Wagner","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060458363","display_name":"Kaneil K. Zadrozny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaneil K Zadrozny","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015601430","display_name":"Jakub Chrustowicz","orcid":"https://orcid.org/0000-0002-3059-1863","observed_orcids":["https://orcid.org/0000-0002-3059-1863"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jakub Chrustowicz","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021125678","display_name":"Michael D. Purdy","orcid":"https://orcid.org/0000-0003-0189-933X","observed_orcids":["https://orcid.org/0000-0003-0189-933X"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D Purdy","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070557615","display_name":"Mark J. Yeager","orcid":"https://orcid.org/0000-0002-3301-640X","observed_orcids":["https://orcid.org/0000-0002-3301-640X"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Yeager","raw_affiliation_strings":["Department of Medicine, Division of Cardiovascular Medicine, University of Virginia Health System, Charlottesville, United States","Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiovascular Medicine, University of Virginia Health System, Charlottesville, United States","institution_ids":["https://openalex.org/I2799765794"]},{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018020732","display_name":"Barbie K. Ganser\u2010Pornillos","orcid":"https://orcid.org/0000-0001-6453-3891","observed_orcids":["https://orcid.org/0000-0001-6453-3891"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Barbie K Ganser-Pornillos","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015481124","display_name":"Owen Pornillos","orcid":"https://orcid.org/0000-0001-9056-5002","observed_orcids":["https://orcid.org/0000-0001-9056-5002"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Owen Pornillos","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States"],"raw_orcid":"https://orcid.org/0000-0001-9056-5002","affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015481124","https://openalex.org/A5018020732","https://openalex.org/A5070557615"],"corresponding_institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I51556381"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":8.4409,"has_fulltext":false,"cited_by_count":136,"citation_normalized_percentile":{"value":0.98169268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"5","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/virus-assembly","display_name":"viral assembly","score":0.7599999904632568},{"id":"https://openalex.org/keywords/virus-maturation","display_name":"virus maturation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gag","display_name":"Gag","score":0.5109999775886536},{"id":"https://openalex.org/keywords/type-ii-beta-turn","display_name":"type II beta-turn","score":0.8069999814033508},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/maturation-inhibitors","display_name":"maturation inhibitors","score":0.7300000190734863},{"id":"https://openalex.org/keywords/retroviruses","display_name":"retroviruses","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C125533998","wikidata":"https://www.wikidata.org/wiki/Q1024499","display_name":"CTD","level":2,"score":0.727896511554718},{"id":"https://openalex.org/C189754071","wikidata":"https://www.wikidata.org/wiki/Q7291972","display_name":"Random hexamer","level":2,"score":0.7165937423706055},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6233280301094055},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.6170336008071899},{"id":"https://openalex.org/C203087120","wikidata":"https://www.wikidata.org/wiki/Q372229","display_name":"Helix bundle","level":3,"score":0.5380871295928955},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5126532912254333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4808419644832611},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.45880427956581116},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.44453439116477966},{"id":"https://openalex.org/C57711820","wikidata":"https://www.wikidata.org/wiki/Q310425","display_name":"C-terminus","level":3,"score":0.43998396396636963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4388248920440674},{"id":"https://openalex.org/C2776086361","wikidata":"https://www.wikidata.org/wiki/Q5189819","display_name":"Cruciform","level":2,"score":0.43057286739349365},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3993382453918457},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.37712863087654114},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3698354959487915},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2615351378917694},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.23729604482650757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19118797779083252},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1167432963848114},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10801461338996887},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019065","descriptor_name":"Virus Assembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.7554/elife.17063","doi":"https://doi.org/10.7554/elife.17063","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.17063","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmid:27416583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27416583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4946879","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4946879/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmh:oai:osti.gov:1267471","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1267471","pdf_url":"https://www.osti.gov/servlets/purl/1267471","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:107050c9c1b2475cb792ed597ac6526a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/107050c9c1b2475cb792ed597ac6526a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 5 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.17063","doi":"https://doi.org/10.7554/elife.17063","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.17063","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2226632435","display_name":"Structure Analysis of Viral Assembly Mechanisms","funder_award_id":"R01GM066087","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2991708791","display_name":"300 keV Liquid Helium Robotic Microscope","funder_award_id":"S10RR025067","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3764877941","display_name":"Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking, and Assembly of HIV (CHEETAH Center)","funder_award_id":"P50GM082545","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4193631363","display_name":"Structural and Functional Integration of TRIM5alpha Domains for HIV Capsid Binding","funder_award_id":"F32GM115007","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6244872863","display_name":"The Center for HIV RNA Studies (CRNA)","funder_award_id":"P50GM103297","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2470140135.pdf","grobid_xml":"https://content.openalex.org/works/W2470140135.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1539796472","https://openalex.org/W1562103219","https://openalex.org/W1595806441","https://openalex.org/W1599995235","https://openalex.org/W1924577704","https://openalex.org/W1925325850","https://openalex.org/W1933776452","https://openalex.org/W1964022123","https://openalex.org/W1971850851","https://openalex.org/W1977218442","https://openalex.org/W1987125112","https://openalex.org/W1997860232","https://openalex.org/W2002672149","https://openalex.org/W2013652077","https://openalex.org/W2015090760","https://openalex.org/W2021064626","https://openalex.org/W2024563086","https://openalex.org/W2033236966","https://openalex.org/W2034897068","https://openalex.org/W2041121767","https://openalex.org/W2042938599","https://openalex.org/W2043560498","https://openalex.org/W2048107562","https://openalex.org/W2049372909","https://openalex.org/W2055673257","https://openalex.org/W2056357424","https://openalex.org/W2061714407","https://openalex.org/W2062334646","https://openalex.org/W2062967707","https://openalex.org/W2068446921","https://openalex.org/W2073585128","https://openalex.org/W2074560169","https://openalex.org/W2084131702","https://openalex.org/W2087978946","https://openalex.org/W2092437950","https://openalex.org/W2096985241","https://openalex.org/W2102953571","https://openalex.org/W2103281794","https://openalex.org/W2106290432","https://openalex.org/W2108699324","https://openalex.org/W2114622716","https://openalex.org/W2115382947","https://openalex.org/W2115851369","https://openalex.org/W2116262094","https://openalex.org/W2124026197","https://openalex.org/W2128780965","https://openalex.org/W2132483341","https://openalex.org/W2134403038","https://openalex.org/W2137919235","https://openalex.org/W2141194382","https://openalex.org/W2142635775","https://openalex.org/W2145652748","https://openalex.org/W2147792469","https://openalex.org/W2152539875","https://openalex.org/W2155921043","https://openalex.org/W2156696460","https://openalex.org/W2156981438","https://openalex.org/W2159504933","https://openalex.org/W2160176988","https://openalex.org/W2163809370","https://openalex.org/W2169408873","https://openalex.org/W2171534744","https://openalex.org/W2171750584","https://openalex.org/W2177995202","https://openalex.org/W2180229411","https://openalex.org/W2412529803","https://openalex.org/W2466725324"],"related_works":["https://openalex.org/W2466725324","https://openalex.org/W2062334646","https://openalex.org/W3138916403","https://openalex.org/W2152539875","https://openalex.org/W2128286418","https://openalex.org/W7095461297","https://openalex.org/W2891492340","https://openalex.org/W2115382947","https://openalex.org/W3120649156","https://openalex.org/W2789880389"],"abstract_inverted_index":{"Virus":[0],"assembly":[1,27,93],"and":[2,16,28,42,73,79,94,139],"maturation":[3,29,131],"proceed":[4],"through":[5],"the":[6,33,38,43,49,58,68,71,80,95,107,136,144],"programmed":[7],"operation":[8],"of":[9,37,48,57,114,123,135,143],"molecular":[10],"switches,":[11],"which":[12,67],"trigger":[13],"both":[14],"local":[15],"global":[17],"structural":[18,51],"rearrangements":[19],"to":[20,147],"produce":[21],"infectious":[22],"particles.":[23],"HIV-1":[24,115,130],"contains":[25],"an":[26,74],"switch":[30],"that":[31,129],"spans":[32],"C-terminal":[34],"domain":[35],"(CTD)":[36],"capsid":[39],"(CA)":[40],"region":[41],"first":[44],"spacer":[45,109],"peptide":[46],"(SP1)":[47],"precursor":[50],"protein,":[52],"Gag.":[53],"The":[54,86],"crystal":[55],"structure":[56],"CTD-SP1":[59],"Gag":[60,116],"fragment":[61],"is":[62,88,110,118],"a":[63,83,111,120],"goblet-shaped":[64],"hexamer":[65],"in":[66],"cup":[69],"comprises":[70,82],"CTD":[72],"ensuing":[75],"type":[76],"II":[77],"\u03b2-turn,":[78],"stem":[81],"6-helix":[84,96],"bundle.":[85],"\u03b2-turn":[87],"critical":[89,112],"for":[90],"immature":[91],"virus":[92],"bundle":[97],"regulates":[98],"proteolysis":[99],"during":[100],"maturation.":[101],"This":[102],"bipartite":[103],"character":[104],"explains":[105],"why":[106],"SP1":[108],"element":[113],"but":[117],"not":[119],"universal":[121],"property":[122],"retroviruses.":[124],"Our":[125],"results":[126],"also":[127],"indicate":[128],"inhibitors":[132],"suppress":[133],"unfolding":[134],"CA-SP1":[137],"junction":[138],"thereby":[140],"delay":[141],"access":[142],"viral":[145],"protease":[146],"its":[148],"substrate.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-07-22T00:00:00"}
