{"id":"https://openalex.org/W2470116295","doi":null,"title":"[Effect of Acupuncture Intervention on Expression of NF-\u03baB Signal Pathway in the Hippocampus of Chronic Stress-induced Depression Rats].","display_name":"[Effect of Acupuncture Intervention on Expression of NF-\u03baB Signal Pathway in the Hippocampus of Chronic Stress-induced Depression Rats].","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W2470116295","mag":"2470116295","pmid":"https://pubmed.ncbi.nlm.nih.gov/26669192"},"language":"zh","primary_location":{"id":"pmid:26669192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26669192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhen ci yan jiu = Acupuncture research","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/ba29880c46f34f70b59f6b6de0a08f37","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030850163","display_name":"Run-Hui Shao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Run-hui Shao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021312198","display_name":"Shu-Ying Jin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shu-ying Jin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027061078","display_name":"Jun L\u00fc","orcid":"https://orcid.org/0000-0002-9141-6786","observed_orcids":["https://orcid.org/0000-0002-9141-6786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103661159","display_name":"Li Hu","orcid":"https://orcid.org/0000-0001-9588-9639","observed_orcids":["https://orcid.org/0000-0001-9588-9639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101547834","display_name":"Ya Tu","orcid":"https://orcid.org/0000-0001-8944-4174","observed_orcids":["https://orcid.org/0000-0001-8944-4174"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya Tu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6403,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.80458049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"40","issue":"5","first_page":"368","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acupuncture","display_name":"acupuncture","score":0.9990000128746033},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8309999704360962},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.6620000004768372},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.824999988079071},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9580000042915344},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/baihui-gv20","display_name":"Baihui (GV20)","score":0.9559999704360962},{"id":"https://openalex.org/keywords/neiguan-pc6","display_name":"Neiguan (PC6)","score":1.0},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.8064537048339844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7586578130722046},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.636555016040802},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6094805598258972},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5999475717544556},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.5631194114685059},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5624673366546631},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.5607349276542664},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.4824569821357727},{"id":"https://openalex.org/C2778654844","wikidata":"https://www.wikidata.org/wiki/Q3305232","display_name":"Chronic stress","level":2,"score":0.4370495080947876},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.41144663095474243},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2102203369140625},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14106807112693787},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.13386669754981995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10099548101425171},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09251430630683899},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015669","descriptor_name":"Acupuncture Points","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:26669192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26669192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhen ci yan jiu = Acupuncture research","raw_type":"English Abstract"},{"id":"pmh:oai:doaj.org/article:5c13e6d2970f4da08f46edca016e8f62","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5c13e6d2970f4da08f46edca016e8f62","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u9488\u523a\u7814\u7a76, Vol 40, Pp 368-372 (2015)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:ba29880c46f34f70b59f6b6de0a08f37","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ba29880c46f34f70b59f6b6de0a08f37","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u9488\u523a\u7814\u7a76, Vol 40, Pp 368-372 (2015)","raw_type":"article"},{"id":"mag:2470116295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26669192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:ba29880c46f34f70b59f6b6de0a08f37","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ba29880c46f34f70b59f6b6de0a08f37","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u9488\u523a\u7814\u7a76, Vol 40, Pp 368-372 (2015)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2558594905","https://openalex.org/W3015567759","https://openalex.org/W4206832387","https://openalex.org/W7162915809","https://openalex.org/W2276225173","https://openalex.org/W3024944268","https://openalex.org/W2366855210","https://openalex.org/W4281816623","https://openalex.org/W7165617232","https://openalex.org/W2370844268"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"observe":[2],"the":[3,9,30,113,127,136,145,158,161,172,178,186,189,200,207,224,230,272],"influence":[4],"of":[5,11,24,32,43,112,132,147,163,191,274],"acupuncture":[6,208,225],"intervention":[7,244],"on":[8],"expression":[10,131],"pivotal":[12],"pro-inflammatory":[13,268],"molecules":[14],"nuclear":[15],"factor-\u03baB":[16],"(NF-\u03baB),":[17],"cyclooxygenase-2":[18],"(COX-2),":[19],"and":[20,59,96,144,149,168,196,209,226,234,236,251,253],"prostaglandin":[21],"E2":[22],"(PGE2)":[23],"NF-\u03baB":[25,133,164,192,231,249],"inflammatory":[26],"signal":[27],"pathway":[28,269],"in":[29,67,135,171,177,199,205,229,256],"hippocampus":[31,137,173,201],"depression":[33,71,257],"rats,":[34,258],"so":[35],"as":[36],"to":[37,92,110,157,185,262,270],"explore":[38],"its":[39,263],"mechanism":[40],"underlying":[41],"improvement":[42],"depression.":[44],"METHODS:":[45],"Thirty-six":[46],"male":[47],"Sprague-Dawley":[48],"rats":[49,66,111],"were":[50,151,174,202],"randomly":[51],"divided":[52],"into":[53],"four":[54],"groups:":[55],"control,":[56],"model,":[57],"acupuncture,":[58],"medication":[60,114,210,227],"(fluoxetine,":[61],"Flu)":[62],"(n":[63],"=":[64],"9":[65],"each":[68],"group).":[69],"The":[70,130],"model":[72,179,187],"was":[73,90,108,139,219],"established":[74],"by":[75,118,141,153,266],"using":[76],"chronic":[77],"unpredictable":[78],"stress":[79,128],"stimuli":[80],"combined":[81],"with":[82],"solitary":[83],"feeding":[84],"for":[85,104,123],"28":[86,105,124],"days.":[87,106],"Acupuncture":[88,243],"treatment":[89],"applied":[91],"\"Baihui\"":[93],"(GV":[94],"20)":[95],"\"Neiguan\"":[97],"(PC":[98],"6)":[99],"once":[100],"every":[101],"other":[102],"day":[103],"Fluoxetine":[107],"given":[109],"group":[115,180],"(10":[116],"mg/kg)":[117],"gavage":[119],"(p.":[120],"o.)":[121],"everyday":[122],"days":[125],"before":[126],"stimulation.":[129],"protein":[134,165,193,232],"tissue":[138],"detected":[140,152],"Western":[142],"blot,":[143],"contents":[146,170,198,238],"COX-2":[148,167,195,235,252],"PGE2":[150,169,197,237,254],"ELISA.":[154],"RESULTS:":[155],"Compared":[156,184],"control":[159],"group,":[160,188],"levels":[162,190,255],"expression,":[166,194,233,250],"significantly":[175,203],"increased":[176],"(P":[181,212,239],"<":[182,213,216],"0.01).":[183,217],"down-regulated":[204],"both":[206],"groups":[211,228],"0.05;":[214],"P":[215],"There":[218],"no":[220],"significant":[221],"differences":[222],"between":[223],">":[240],"0.05).":[241],"CONCLUSION:":[242],"can":[245],"effectively":[246],"reduce":[247],"hippocampal":[248],"which":[259],"may":[260],"contribute":[261],"anti-depressant":[264],"effect":[265],"inhibiting":[267],"protect":[271],"neurons":[273],"hippocampus.":[275]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}