{"id":"https://openalex.org/W2469877339","doi":null,"title":"Overview of Voriconazole Pharmacokinetics and Pharmacodynamic Parameters","display_name":"Overview of Voriconazole Pharmacokinetics and Pharmacodynamic Parameters","publication_year":2016,"publication_date":"2016-05-15","ids":{"openalex":"https://openalex.org/W2469877339","mag":"2469877339"},"language":"en","primary_location":{"id":"mag:2469877339","doi":null,"is_oa":true,"landing_page_url":"https://jmums.mazums.ac.ir/browse.php?a_id=7524&sid=1&slc_lang=en","pdf_url":null,"source":{"id":"https://openalex.org/S2765058559","display_name":"Majallah-i d\u0101nishg\u0101h-i \u0312ul\u016bm-i pizishk\u012b-i M\u0101zandar\u0101n/Journal of Mazandaran University of Medical Sciences","issn_l":"1735-9260","issn":["1735-9260"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319134","host_organization_name":"Mazandaran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319134"],"host_organization_lineage_names":["Mazandaran University of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i d\u0101nishg\u0101h-i \u0312ul\u016bm-i pizishk\u012b-i M\u0101zandar\u0101n/Journal of Mazandaran University of Medical Sciences","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jmums.mazums.ac.ir/browse.php?a_id=7524&sid=1&slc_lang=en","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084005100","display_name":"Hamid Badali","orcid":"https://orcid.org/0000-0002-6010-8414","observed_orcids":["https://orcid.org/0000-0002-6010-8414"]},"institutions":[{"id":"https://openalex.org/I88085062","display_name":"Mazandaran University of Medical Sciences","ror":"https://ror.org/02wkcrp04","country_code":"IR","type":"education","lineage":["https://openalex.org/I88085062"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hamid Badali","raw_affiliation_strings":["Associate Professor, Invasive Fungi Research Centre, Department of Medical Mycology and Parasitology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran"],"raw_orcid":"https://orcid.org/0000-0002-6010-8414","affiliations":[{"raw_affiliation_string":"Associate Professor, Invasive Fungi Research Centre, Department of Medical Mycology and Parasitology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran","institution_ids":["https://openalex.org/I88085062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057234247","display_name":"Afsane Vaezi","orcid":"https://orcid.org/0000-0001-8261-7386","observed_orcids":["https://orcid.org/0000-0001-8261-7386"]},"institutions":[{"id":"https://openalex.org/I88085062","display_name":"Mazandaran University of Medical Sciences","ror":"https://ror.org/02wkcrp04","country_code":"IR","type":"education","lineage":["https://openalex.org/I88085062"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Afsane Vaezi","raw_affiliation_strings":["PhD Student in Medical Mycology, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran"],"raw_orcid":"https://orcid.org/0000-0001-8261-7386","affiliations":[{"raw_affiliation_string":"PhD Student in Medical Mycology, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran","institution_ids":["https://openalex.org/I88085062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076506705","display_name":"Narges Aslani","orcid":"https://orcid.org/0000-0003-4142-2173","observed_orcids":["https://orcid.org/0000-0003-4142-2173"]},"institutions":[{"id":"https://openalex.org/I88085062","display_name":"Mazandaran University of Medical Sciences","ror":"https://ror.org/02wkcrp04","country_code":"IR","type":"education","lineage":["https://openalex.org/I88085062"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Narges Aslani","raw_affiliation_strings":["PhD Student in Medical Mycology, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran"],"raw_orcid":"https://orcid.org/0000-0003-4142-2173","affiliations":[{"raw_affiliation_string":"PhD Student in Medical Mycology, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran","institution_ids":["https://openalex.org/I88085062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035596120","display_name":"Nina Zahedi","orcid":"https://orcid.org/0000-0002-6662-5607","observed_orcids":["https://orcid.org/0000-0002-6662-5607"]},"institutions":[{"id":"https://openalex.org/I88085062","display_name":"Mazandaran University of Medical Sciences","ror":"https://ror.org/02wkcrp04","country_code":"IR","type":"education","lineage":["https://openalex.org/I88085062"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nina Zahedi","raw_affiliation_strings":["MSc in Medical Mycology, Invasive Fungi Research Centre, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran"],"raw_orcid":"https://orcid.org/0000-0002-6662-5607","affiliations":[{"raw_affiliation_string":"MSc in Medical Mycology, Invasive Fungi Research Centre, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran","institution_ids":["https://openalex.org/I88085062"]}]},{"author_position":"last","author":{"id":null,"display_name":"Mohammad Bagher Shiran","orcid":"https://orcid.org/0000-0002-5700-3937","observed_orcids":["https://orcid.org/0000-0002-5700-3937"]},"institutions":[{"id":"https://openalex.org/I88085062","display_name":"Mazandaran University of Medical Sciences","ror":"https://ror.org/02wkcrp04","country_code":"IR","type":"education","lineage":["https://openalex.org/I88085062"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Bagher Shiran","raw_affiliation_strings":["Associate Professor, Immunogenetic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran"],"raw_orcid":"https://orcid.org/0000-0002-5700-3937","affiliations":[{"raw_affiliation_string":"Associate Professor, Immunogenetic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran","institution_ids":["https://openalex.org/I88085062"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I88085062"],"apc_list":{"value":3000000,"currency":"IRR","value_usd":null},"apc_paid":null,"fwci":0.2591,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.60503257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"26","issue":"136","first_page":"225","last_page":"235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voriconazole","display_name":"voriconazole","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triazole-antifungals","display_name":"triazole antifungals","score":0.8270000219345093},{"id":"https://openalex.org/keywords/invasive-fungal-infections","display_name":"invasive fungal infections","score":0.9399999976158142},{"id":"https://openalex.org/keywords/nonlinear-pharmacokinetics","display_name":"nonlinear pharmacokinetics","score":0.859000027179718},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9179999828338623},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.8960000276565552},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"area under the curve","score":0.8100000023841858},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.8740000128746033},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2780690907","wikidata":"https://www.wikidata.org/wiki/Q412236","display_name":"Voriconazole","level":3,"score":0.9834040999412537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8636521697044373},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8357876539230347},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.7415274381637573},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7046337127685547},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6408531665802002},{"id":"https://openalex.org/C140840227","wikidata":"https://www.wikidata.org/wiki/Q3737532","display_name":"CYP2C19","level":4,"score":0.5073758959770203},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.4841402471065521},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.4815242886543274},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.4630584418773651},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4601351320743561},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.43487516045570374},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.4312480390071869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21881964802742004},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.16323208808898926},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.08910906314849854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.062409907579422},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.053715914487838745},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2469877339","doi":null,"is_oa":true,"landing_page_url":"https://jmums.mazums.ac.ir/browse.php?a_id=7524&sid=1&slc_lang=en","pdf_url":null,"source":{"id":"https://openalex.org/S2765058559","display_name":"Majallah-i d\u0101nishg\u0101h-i \u0312ul\u016bm-i pizishk\u012b-i M\u0101zandar\u0101n/Journal of Mazandaran University of Medical Sciences","issn_l":"1735-9260","issn":["1735-9260"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319134","host_organization_name":"Mazandaran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319134"],"host_organization_lineage_names":["Mazandaran University of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i d\u0101nishg\u0101h-i \u0312ul\u016bm-i pizishk\u012b-i M\u0101zandar\u0101n/Journal of Mazandaran University of Medical Sciences","raw_type":null}],"best_oa_location":{"id":"mag:2469877339","doi":null,"is_oa":true,"landing_page_url":"https://jmums.mazums.ac.ir/browse.php?a_id=7524&sid=1&slc_lang=en","pdf_url":null,"source":{"id":"https://openalex.org/S2765058559","display_name":"Majallah-i d\u0101nishg\u0101h-i \u0312ul\u016bm-i pizishk\u012b-i M\u0101zandar\u0101n/Journal of Mazandaran University of Medical Sciences","issn_l":"1735-9260","issn":["1735-9260"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319134","host_organization_name":"Mazandaran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319134"],"host_organization_lineage_names":["Mazandaran University of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i d\u0101nishg\u0101h-i \u0312ul\u016bm-i pizishk\u012b-i M\u0101zandar\u0101n/Journal of Mazandaran University of Medical Sciences","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1563224671","https://openalex.org/W1583928669","https://openalex.org/W1957310509","https://openalex.org/W1978261301","https://openalex.org/W1984471111","https://openalex.org/W1986133100","https://openalex.org/W1991884176","https://openalex.org/W2014557179","https://openalex.org/W2014908403","https://openalex.org/W2024059428","https://openalex.org/W2038952217","https://openalex.org/W2047634194","https://openalex.org/W2051135531","https://openalex.org/W2051816101","https://openalex.org/W2062983075","https://openalex.org/W2063905878","https://openalex.org/W2070463480","https://openalex.org/W2076522986","https://openalex.org/W2079899732","https://openalex.org/W2090225402","https://openalex.org/W2101089712","https://openalex.org/W2104186094","https://openalex.org/W2104419186","https://openalex.org/W2115676717","https://openalex.org/W2118847922","https://openalex.org/W2121959809","https://openalex.org/W2122561192","https://openalex.org/W2127422954","https://openalex.org/W2135315031","https://openalex.org/W2140173966","https://openalex.org/W2158172729","https://openalex.org/W2161744315","https://openalex.org/W2166682252","https://openalex.org/W2264943376","https://openalex.org/W2268592457","https://openalex.org/W2278310178","https://openalex.org/W2305251607","https://openalex.org/W2474108139","https://openalex.org/W2520457341"],"related_works":["https://openalex.org/W2361047800","https://openalex.org/W1992995027","https://openalex.org/W4237615604","https://openalex.org/W2115676717","https://openalex.org/W7098168070","https://openalex.org/W4387362824","https://openalex.org/W7095950517","https://openalex.org/W2117125304","https://openalex.org/W1987069059","https://openalex.org/W2913093012"],"abstract_inverted_index":{"Voriconazole":[0,39],"is":[1,15,36,61,103],"an":[2,45],"antifungal":[3],"triazole,":[4],"approved":[5],"for":[6,148],"management":[7],"of":[8,59,66,86,108,140],"invasive":[9],"fungal":[10],"diseases":[11],"in":[12,44,91,121],"patients.":[13],"It":[14],"absorbed":[16],"during":[17],"two":[18],"hours":[19],"and":[20,69,83,97,111,127,145],"its":[21],"serum":[22],"levels":[23],"will":[24],"be":[25],"above":[26],"90%,":[27],"based":[28],"on":[29],"the":[30,34,48,67,87,117,141],"underlying":[31],"factors,":[32],"when":[33],"drug":[35,68,101,125],"administered":[37],"orally.":[38],"shows":[40],"a":[41,137],"propotional":[42],"increase":[43],"area":[46],"under":[47],"plasma":[49],"concentration-time":[50],"curve":[51],"(AUC),":[52],"with":[53],"increasing":[54],"dose.":[55],"Plasma":[56],"protein":[57],"binding":[58],"voriconazole":[60,149],"approximately":[62],"60%.":[63],"Standard":[64],"doses":[65],"optimal":[70],"concentration":[71],"are":[72],"not":[73],"predictable":[74],"due":[75],"to":[76,93],"voriconazole\u2019s":[77],"nonlinear":[78],"pharmacokinetics,":[79],"drug-drug":[80],"interactions,":[81],"age,":[82],"genetic":[84],"polymorphisms":[85],"cytochrome":[88],"CYP2C19.":[89],"Therefore,":[90],"order":[92],"prevent":[94],"adverse":[95],"effects":[96],"optimize":[98],"outcomes,":[99],"therapeutic":[100],"monitoring":[102],"highly":[104],"suggested.":[105],"The":[106,132],"application":[107],"linking":[109],"pharmacokinetic":[110,144],"pharmacodynamics":[112,146],"characteristics":[113],"provides":[114],"information":[115],"about":[116],"relationships":[118],"between":[119,143],"antimicrobial":[120,128],"vitro":[122],"susceptibility,":[123],"dosage,":[124],"concentrations":[126],"or":[129],"toxicological":[130],"effects.":[131],"current":[133],"review":[134],"paper":[135],"presents":[136],"comprehensive":[138],"overview":[139],"relation":[142],"parameters":[147],"treatment":[150],"efficacy.":[151]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
