{"id":"https://openalex.org/W2469766320","doi":"https://doi.org/10.1111/pan.12954","title":"An automated real\u2010time method for the detection of patients at risk for malignant hyperthermia","display_name":"An automated real\u2010time method for the detection of patients at risk for malignant hyperthermia","publication_year":2016,"publication_date":"2016-06-27","ids":{"openalex":"https://openalex.org/W2469766320","doi":"https://doi.org/10.1111/pan.12954","mag":"2469766320","pmid":"https://pubmed.ncbi.nlm.nih.gov/27346873"},"language":"en","primary_location":{"id":"doi:10.1111/pan.12954","doi":"https://doi.org/10.1111/pan.12954","is_oa":false,"landing_page_url":"https://doi.org/10.1111/pan.12954","pdf_url":null,"source":{"id":"https://openalex.org/S192565471","display_name":"Pediatric Anesthesia","issn_l":"1155-5645","issn":["1155-5645","1460-9592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Anesthesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088925235","display_name":"Stephen J. Gleich","orcid":"https://orcid.org/0000-0002-3791-5015","observed_orcids":["https://orcid.org/0000-0002-3791-5015"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen J. Gleich","raw_affiliation_strings":["Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004397121","display_name":"Kim M. Strupp","orcid":"https://orcid.org/0000-0002-5674-3909","observed_orcids":["https://orcid.org/0000-0002-5674-3909"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim Strupp","raw_affiliation_strings":["Department of Anesthesiology, University of Colorado School of Medicine, Denver, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Colorado School of Medicine, Denver, CO, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113653388","display_name":"Robert T. Wilder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T. Wilder","raw_affiliation_strings":["Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103192518","display_name":"Daryl Jon Kor","orcid":"https://orcid.org/0000-0001-9110-1648","observed_orcids":["https://orcid.org/0000-0001-9110-1648"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daryl J. Kor","raw_affiliation_strings":["Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113554548","display_name":"Randall P. Flick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall Flick","raw_affiliation_strings":["Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088925235"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4080,"currency":"USD","value_usd":4080},"apc_paid":null,"fwci":1.4669,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82392924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"9","first_page":"876","last_page":"882"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.5770999789237976,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.5770999789237976,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.20810000598430634,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13248","display_name":"Healthcare Technology and Patient Monitoring","score":0.12380000203847885,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-hyperthermia","display_name":"malignant hyperthermia","score":1.0},{"id":"https://openalex.org/keywords/anesthesia-information-management-systems","display_name":"anesthesia information management systems","score":0.7950000166893005},{"id":"https://openalex.org/keywords/real-time-patient-monitoring","display_name":"real-time patient monitoring","score":0.6389999985694885},{"id":"https://openalex.org/keywords/end-tidal-carbon-dioxide","display_name":"end-tidal carbon dioxide","score":0.7940000295639038},{"id":"https://openalex.org/keywords/body-temperature","display_name":"body temperature","score":0.5400000214576721},{"id":"https://openalex.org/keywords/clinical-grading-scale","display_name":"clinical grading scale","score":0.5950000286102295},{"id":"https://openalex.org/keywords/false-positive-alarms","display_name":"false positive alerts","score":0.8849999904632568},{"id":"https://openalex.org/keywords/alarm-fatigue","display_name":"alarm fatigue","score":0.878000020980835},{"id":"https://openalex.org/keywords/operating-room-patients","display_name":"operating room patients","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9126875996589661},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5960302352905273},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5568171143531799},{"id":"https://openalex.org/C2781460320","wikidata":"https://www.wikidata.org/wiki/Q421274","display_name":"Dantrolene","level":3,"score":0.5305711627006531},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4841931164264679},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.47659772634506226},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.40683919191360474},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.3443489372730255},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3236343264579773},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2652168571949005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2139466404914856},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C147176958","wikidata":"https://www.wikidata.org/wiki/Q77590","display_name":"Civil engineering","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003661","descriptor_name":"Decision Support Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008305","descriptor_name":"Malignant Hyperthermia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008305","descriptor_name":"Malignant Hyperthermia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019095","descriptor_name":"Point-of-Care Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/pan.12954","doi":"https://doi.org/10.1111/pan.12954","is_oa":false,"landing_page_url":"https://doi.org/10.1111/pan.12954","pdf_url":null,"source":{"id":"https://openalex.org/S192565471","display_name":"Pediatric Anesthesia","issn_l":"1155-5645","issn":["1155-5645","1460-9592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Anesthesia","raw_type":"journal-article"},{"id":"pmid:27346873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27346873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatric anaesthesia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1977990077","https://openalex.org/W1986747467","https://openalex.org/W2020223073","https://openalex.org/W2020425680","https://openalex.org/W2022273963","https://openalex.org/W2034533898","https://openalex.org/W2042616828","https://openalex.org/W2075959901","https://openalex.org/W2080273051","https://openalex.org/W2081715712","https://openalex.org/W2082317729","https://openalex.org/W2138251630","https://openalex.org/W2163354078","https://openalex.org/W2165820685"],"related_works":["https://openalex.org/W2090794683","https://openalex.org/W2018407428","https://openalex.org/W2322433554","https://openalex.org/W3110345463","https://openalex.org/W7164858804","https://openalex.org/W2239750260","https://openalex.org/W4313217349","https://openalex.org/W6979126449","https://openalex.org/W2159805445","https://openalex.org/W4394963771"],"abstract_inverted_index":{"BACKGROUND:":[0],"Malignant":[1],"hyperthermia":[2],"(MH)":[3],"is":[4,22,266],"a":[5,70,96,134,237,255],"rare":[6],"anesthetic":[7],"pharmacogenetic":[8],"disorder":[9],"that":[10,265,295],"can":[11],"be":[12,298],"difficult":[13],"to":[14,24,47,58,82,87,94,107,128,133,146,183,209,236,249,269,279,287],"detect":[15],"in":[16],"its":[17],"earliest":[18],"phases.":[19],"Prompt":[20],"treatment":[21,296],"known":[23],"improve":[25],"outcomes.":[26],"The":[27,102,122],"modern":[28],"anesthesia":[29],"information":[30],"management":[31],"systems":[32],"(AIMS)":[33],"collect":[34],"enormous":[35],"amounts":[36],"of":[37,69,78,91,137,190,241,291],"data.":[38],"However,":[39],"data":[40,111,187],"lack":[41],"context":[42],"and":[43,67,93,119,132,197],"are":[44],"not":[45],"able":[46],"provide":[48],"real-time":[49,71,256],"guidance.":[50],"Utilizing":[51],"our":[52,191,214],"AIMS,":[53],"we":[54],"developed":[55],"the":[56,65,89,129,156,163,166,232,285,289],"capacity":[57],"incorporate":[59],"decision":[60],"support.":[61],"AIMS:":[62],"We":[63,170,253],"describe":[64],"creation":[66],"evaluation":[68],"detection":[72,157,258],"tool":[73,158,259],"for":[74,151,227,273],"MH.":[75],"METHODS:":[76],"Cases":[77],"MH":[79,92,97,153,176,178,205,229,257,293],"from":[80,143,181,204,246],"2003":[81],"2013":[83],"were":[84,105,124,195,223,234],"retrospectively":[85,127],"reviewed":[86],"confirm":[88],"diagnosis":[90],"calculate":[95],"clinical":[98],"grading":[99],"scale":[100],"score.":[101],"index":[103,130,193,215],"cases":[104,131,194,216,245,271],"utilized":[106],"develop":[108],"four":[109,186],"electronic":[110],"Rules,":[112,188],"based":[113,260],"on":[114,162,261],"endtidal":[115],"CO2":[116],"(ETCO2":[117],")":[118],"temperature":[120],"criteria.":[121],"Rules":[123,233],"then":[125],"applied":[126,235],"full":[135],"cohort":[136,240],"general":[138,238],"operating":[139],"room":[140],"(OR)":[141],"patients":[142,173],"January":[144,247],"2012":[145,248],"June":[147,250],"2012.":[148,251],"If":[149],"criteria":[150,264],"possible":[152,228,292],"was":[154,217],"met,":[155],"generated":[159,198],"an":[160,199],"alert":[161,207],"monitor":[164],"at":[165],"patient's":[167],"bedside.":[168],"RESULTS:":[169],"identified":[171],"seven":[172,192],"with":[174,177],"confirmed":[175],"Scores":[179],"ranging":[180],"28":[182],"70.":[184],"Using":[185],"all":[189],"captured":[196],"appropriate":[200],"alert.":[201],"Median":[202],"time":[203,208,212],"computer":[206],"dantrolene":[210],"administration":[211],"among":[213],"23":[218],"min":[219],"(IQR":[220],"17-77).":[221],"There":[222],"938":[224],"false-positive":[225],"alerts":[226],"(1.8%)":[230],"when":[231],"OR":[239],"51":[242],"579":[243],"total":[244],"CONCLUSIONS:":[252],"demonstrated":[254],"established":[262],"physiologic":[263],"sensitive":[267],"enough":[268],"capture":[270],"suspicious":[272],"MH,":[274],"while":[275],"limiting":[276],"false":[277],"positives":[278],"prevent":[280],"alarm":[281],"fatigue.":[282],"This":[283],"has":[284],"potential":[286],"notify":[288],"provider":[290],"such":[294],"may":[297],"rapidly":[299],"initiated.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}