{"id":"https://openalex.org/W2469748215","doi":null,"title":"The use of magnetic resonance spectroscopy in the evaluation of the natural history of multiple sclerosis.","display_name":"The use of magnetic resonance spectroscopy in the evaluation of the natural history of multiple sclerosis.","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2469748215","mag":"2469748215","pmid":"https://pubmed.ncbi.nlm.nih.gov/9647294"},"language":"en","primary_location":{"id":"pmid:9647294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9647294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology, neurosurgery, and psychiatry","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065754098","display_name":"Douglas Lorne Arnold","orcid":"https://orcid.org/0000-0003-4266-0106","observed_orcids":["https://orcid.org/0000-0003-4266-0106","https://orcid.org/0000-0002-0805-7672"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D L Arnold","raw_affiliation_strings":["Montreal Neurological Institute, McGill University, Quebec, Canada. doug@mrs.mni.mcgill.ca","Montr\u00e9al Neurological Institute, McGill University, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montreal Neurological Institute, McGill University, Quebec, Canada. doug@mrs.mni.mcgill.ca","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Montr\u00e9al Neurological Institute, McGill University, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012511970","display_name":"J. S. Wolinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J S Wolinsky","raw_affiliation_strings":["University of Texas at Austin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Austin","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070529061","display_name":"Paul McMahan Matthews","orcid":"https://orcid.org/0000-0002-1619-8328","observed_orcids":["https://orcid.org/0000-0002-1619-8328"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P M Matthews","raw_affiliation_strings":["University of Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062699033","display_name":"Andrea Falini","orcid":"https://orcid.org/0000-0002-1461-8755","observed_orcids":["https://orcid.org/0000-0002-1461-8755"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Falini","raw_affiliation_strings":["Vita-Salute San Raffaele University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vita-Salute San Raffaele University","institution_ids":["https://openalex.org/I154387261"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1366,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.9577597,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"64 Suppl 1","issue":null,"first_page":"S94","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/magnetic-resonance-spectroscopic-imaging","display_name":"magnetic resonance spectroscopic imaging","score":0.9599999785423279},{"id":"https://openalex.org/keywords/natural-history-disease","display_name":"natural history (disease)","score":0.875},{"id":"https://openalex.org/keywords/lesion-evolution","display_name":"lesion evolution","score":0.8560000061988831},{"id":"https://openalex.org/keywords/normal-appearing-white-matter","display_name":"normal-appearing white matter","score":0.9580000042915344},{"id":"https://openalex.org/keywords/clinical-disability","display_name":"clinical disability","score":0.9559999704360962},{"id":"https://openalex.org/keywords/drug-efficacy-evaluation","display_name":"drug efficacy evaluation","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8686723709106445},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6967540383338928},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5363980531692505},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5359265208244324},{"id":"https://openalex.org/C163276114","wikidata":"https://www.wikidata.org/wiki/Q484591","display_name":"Natural history","level":2,"score":0.5280975699424744},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.46544918417930603},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.4634314477443695},{"id":"https://openalex.org/C96781048","wikidata":"https://www.wikidata.org/wiki/Q6731601","display_name":"Magnetic resonance spectroscopic imaging","level":3,"score":0.4522245526313782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4122288227081299},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27923595905303955},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20368990302085876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16619089245796204},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1450943946838379},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1133902370929718}],"mesh":[{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:9647294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9647294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology, neurosurgery, and psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/4948","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/4948","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2469748215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9647294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2400870570","https://openalex.org/W2082850138","https://openalex.org/W2610449028","https://openalex.org/W2324025256","https://openalex.org/W1171800590","https://openalex.org/W51345259","https://openalex.org/W2075269441","https://openalex.org/W2800290335","https://openalex.org/W4248048404","https://openalex.org/W2144153615"],"abstract_inverted_index":{"Magnetic":[0,21],"resonance":[1,22],"spectroscopic":[2],"imaging":[3],"(MRSI)":[4],"can":[5],"be":[6],"used":[7],"to":[8,50,75],"define":[9],"specific":[10],"chemical-pathological":[11],"changes":[12],"in":[13,80],"the":[14,30,35,58],"brain":[15],"of":[16,29,32,37,57,60,77],"patients":[17,61],"with":[18,62],"multiple":[19,63],"sclerosis.":[20],"spectroscopy":[23],"offers":[24],"promise":[25],"for":[26],"improved":[27],"definition":[28],"nature":[31],"individual":[33],"lesions,":[34],"dynamics":[36],"their":[38,40,48],"evolution,":[39],"effects":[41,79],"on":[42],"normal":[43],"appearing":[44],"white":[45],"matter,":[46],"and":[47,71],"relation":[49],"clinical":[51],"disability.":[52],"Combined":[53],"multimodal":[54],"MRSI":[55],"studies":[56],"brains":[59],"sclerosis":[64],"therefore":[65],"soon":[66],"may":[67],"provide":[68],"efficient,":[69],"specific,":[70],"quantitative":[72],"new":[73],"approaches":[74],"assessment":[76],"drug":[78],"therapeutic":[81],"trials.":[82]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-07-22T00:00:00"}