{"id":"https://openalex.org/W2469729326","doi":null,"title":"[Efficacy and toxicity of vinorelbine (NVB)-based regimens in patients with metastatic triple negative breast cancer (mTNBC) pretreated with anthracyclines and taxanes].","display_name":"[Efficacy and toxicity of vinorelbine (NVB)-based regimens in patients with metastatic triple negative breast cancer (mTNBC) pretreated with anthracyclines and taxanes].","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W2469729326","mag":"2469729326","pmid":"https://pubmed.ncbi.nlm.nih.gov/26813602"},"language":"en","primary_location":{"id":"pmid:26813602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26813602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua zhong liu za zhi [Chinese journal of oncology]","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101478862","display_name":"Feng Du","orcid":"https://orcid.org/0000-0002-3709-1933","observed_orcids":["https://orcid.org/0000-0002-3709-1933"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Du","raw_affiliation_strings":["Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059906168","display_name":"Peng Yuan","orcid":"https://orcid.org/0000-0003-3019-0688","observed_orcids":["https://orcid.org/0000-0003-3019-0688"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Yuan","raw_affiliation_strings":["Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060247412","display_name":"Yang Luo","orcid":"https://orcid.org/0000-0002-0166-9027","observed_orcids":["https://orcid.org/0000-0002-0166-9027"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Luo","raw_affiliation_strings":["Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368327","display_name":"Jiayu Wang","orcid":"https://orcid.org/0000-0003-0470-0322","observed_orcids":["https://orcid.org/0000-0003-0470-0322"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayu Wang","raw_affiliation_strings":["Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008584660","display_name":"Fei Ma","orcid":"https://orcid.org/0000-0001-9432-1902","observed_orcids":["https://orcid.org/0000-0001-9432-1902"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Ma","raw_affiliation_strings":["Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113729720","display_name":"Ruigang Cai","orcid":"https://orcid.org/0009-0003-1652-671X","observed_orcids":["https://orcid.org/0009-0003-1652-671X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruigang Cai","raw_affiliation_strings":["Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009635682","display_name":"Ying Fan","orcid":"https://orcid.org/0000-0002-2532-9254","observed_orcids":["https://orcid.org/0000-0002-2532-9254"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Fan","raw_affiliation_strings":["Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404169","display_name":"Qing Li","orcid":"https://orcid.org/0000-0003-2652-6070","observed_orcids":["https://orcid.org/0000-0003-2652-6070","https://orcid.org/0000-0003-1967-2280"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Li","raw_affiliation_strings":["Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101567919","display_name":"Pin Zhang","orcid":"https://orcid.org/0000-0002-7141-9541","observed_orcids":["https://orcid.org/0000-0002-7141-9541"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pin Zhang","raw_affiliation_strings":["Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008098651","display_name":"Binghe Xu","orcid":"https://orcid.org/0000-0003-4195-337X","observed_orcids":["https://orcid.org/0000-0003-4195-337X","https://orcid.org/0000-0002-0234-2747","https://orcid.org/0000-0002-6863-5024"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binghe Xu","raw_affiliation_strings":["Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China; Email: xubinghe@medmail.com.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China; Email: xubinghe@medmail.com.cn","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1304,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.57993507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"37","issue":"10","first_page":"788","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4763000011444092,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vinorelbine","display_name":"vinorelbine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/metastatic-triple-negative-breast-cancer","display_name":"metastatic triple-negative breast cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/second-line-chemotherapy","display_name":"second-line chemotherapy","score":0.7099999785423279},{"id":"https://openalex.org/keywords/anthracycline-pretreated","display_name":"anthracycline pretreated","score":0.7350000143051147},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.7459999918937683},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9610000252723694},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7960000038146973},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.9589999914169312},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.7039999961853027},{"id":"https://openalex.org/keywords/treatment-delay","display_name":"treatment delay","score":0.6880000233650208},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8876583576202393},{"id":"https://openalex.org/C2780350996","wikidata":"https://www.wikidata.org/wiki/Q420532","display_name":"Vinorelbine","level":4,"score":0.863140344619751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7166225910186768},{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.7132108211517334},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.6575175523757935},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6254686713218689},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5948075652122498},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5286978483200073},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5169703364372253},{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.4824872314929962},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.46627476811408997},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44190797209739685},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.43231239914894104},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3438725769519806},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.07582077383995056},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.059608399868011475}],"mesh":[{"descriptor_ui":"D000069287","descriptor_name":"Capecitabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069287","descriptor_name":"Capecitabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069287","descriptor_name":"Capecitabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000077235","descriptor_name":"Vinorelbine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077235","descriptor_name":"Vinorelbine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077235","descriptor_name":"Vinorelbine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:26813602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26813602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua zhong liu za zhi [Chinese journal of oncology]","raw_type":"Journal Article"},{"id":"mag:2469729326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26813602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030044804","https://openalex.org/W2025504439","https://openalex.org/W4248935919","https://openalex.org/W2360991086","https://openalex.org/W2068339772","https://openalex.org/W2550863097","https://openalex.org/W2123082307","https://openalex.org/W2380919243","https://openalex.org/W2800764403","https://openalex.org/W2332220903"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,39,103,130,135,164,170,187,204,207,221,242,258],"efficacy":[4,277],"of":[5,26,44,88,133,251],"vinorelbine":[6],"(NVB)-based":[7],"regimens":[8],"in":[9,62,85,129,169,186,203,257,278,303,309],"patients":[10,28,52,70,82,108,118,252,280],"with":[11,19,55,111,119,282,287],"metastatic":[12,78],"triple":[13],"negative":[14],"breast":[15],"cancer":[16],"(mTNBC)":[17],"pretreated":[18,54,281],"anthracyclines":[20,56,283],"and":[21,30,36,57,69,95,116,154,232,245,261,267,284,298],"taxanes.":[22],"METHODS:":[23],"Clinical":[24],"data":[25],"48":[27,81],"diagnosed":[29],"treated":[31,110],"for":[32,67],"mTNBC":[33,68,279],"between":[34,241],"2004":[35],"2012":[37],"at":[38,58,74],"Cancer":[40],"Hospital,":[41],"Chinese":[42],"Academy":[43],"Medical":[45],"Sciences":[46],"(CAMS)":[47],"were":[48,53,83,109,227],"retrospectively":[49],"analyzed.":[50],"All":[51],"least":[59,75],"one":[60,76,285],"taxane":[61,286],"neo-adjuvant,":[63],"adjuvant":[64],"or":[65],"chemotherapy":[66,94,255,274],"should":[71,299],"be":[72,300],"having":[73],"measurable":[77],"lesion.":[79],"Totally,":[80],"included":[84],"this":[86],"study,":[87],"which":[89],"21":[90],"cases":[91,97],"received":[92,98],"first-line":[93],"27":[96],"second-line":[99],"chemotherapy.":[100],"Based":[101],"on":[102],"regimen":[104,291],"they":[105],"received,":[106],"22":[107],"NVB":[112,120],"plus":[113,121],"platinum":[114],"(NP),":[115],"26":[117],"capecitabine":[122],"(NX).":[123],"RESULTS:":[124],"After":[125],"70":[126],"months":[127,153],"follow-up,":[128],"total":[131],"group":[132],"patients,":[134],"objective":[136],"response":[137],"rate":[138,143],"was":[139,144,151,159,166,183,201,209,239,264],"20.8%,":[140],"clinical":[141,307],"benefit":[142],"43.8%,":[145],"median":[146,155],"progression":[147],"free":[148],"survival":[149,157],"(PFS)":[150],"4.4":[152],"overall":[156],"(OS)":[158],"15.5":[160],"months.":[161],"In":[162,219],"addition,":[163],"ORR":[165],"significantly":[167],"better":[168],"NP":[171,188,243,259,290],"arm":[172,175,189,192,244,247,260,263],"versus":[173],"NX":[174,191,246,262,296],"(33.8%":[176],"vs.7.7%,":[177],"P=0.029)":[178],"as":[179,181],"well":[180],"PFS":[182],"statistically":[184,211],"improved":[185],"than":[190],"(5.3":[193],"m":[194,214],"vs.":[195,215],"3.0":[196],"m,":[197,217],"P=0.023).":[198],"Similar":[199],"trend":[200],"observed":[202,240],"OS,":[205],"although":[206],"difference":[208,238],"not":[210],"significant":[212,237],"(27.7":[213],"14.8":[216],"P=0.077).":[218],"all,":[220],"most":[222],"frequently":[223],"reported":[224],"adverse":[225],"events":[226],"G1/2":[228],"gastrointestinal":[229],"toxicity":[230],"(68.8%)":[231],"neutropenia":[233],"(62.5%)":[234],".":[235],"No":[236],"(P>0.05).":[248],"The":[249],"percentage":[250],"who":[253],"delayed":[254],"administration":[256],"9.1%":[265],"(n=2),":[266],"3.8%":[268],"(n=1),":[269],"respectively.":[270],"CONCLUSIONS:":[271],"NVB-based":[272],"combination":[273],"demonstrates":[275],"moderate":[276],"manageable":[288],"toxicity.":[289],"shows":[292],"potential":[293],"superiority":[294],"over":[295],"regimen,":[297],"further":[301],"verified":[302],"randomized":[304],"phase":[305],"III":[306],"trial":[308],"larger":[310],"cohort.":[311]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}