{"id":"https://openalex.org/W2469178653","doi":null,"title":"Inhibition of differentiation in myoblasts deprived of the interferon-related protein PC4.","display_name":"Inhibition of differentiation in myoblasts deprived of the interferon-related protein PC4.","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W2469178653","mag":"2469178653","pmid":"https://pubmed.ncbi.nlm.nih.gov/7756174"},"language":"en","primary_location":{"id":"pmid:7756174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7756174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090826499","display_name":"Daniele Guardavaccaro","orcid":"https://orcid.org/0000-0002-4517-1765","observed_orcids":["https://orcid.org/0000-0002-4517-1765"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Guardavaccaro","raw_affiliation_strings":["Istituto di Neurobiologia, Consiglio Nazionale delle Ricerche, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Neurobiologia, Consiglio Nazionale delle Ricerche, Rome, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110136821","display_name":"Maria Teresa Ciotti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M T Ciotti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043116632","display_name":"Beat W. Sch\u00e4fer","orcid":"https://orcid.org/0000-0001-5988-2915","observed_orcids":["https://orcid.org/0000-0001-5988-2915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B W Sch\u00e4fer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114134797","display_name":"Alessia Montagnoli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Montagnoli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020791097","display_name":"Felice Tirone","orcid":"https://orcid.org/0000-0002-0980-4377","observed_orcids":["https://orcid.org/0000-0002-0980-4377"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Tirone","raw_affiliation_strings":["Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6225,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.64764596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"6","issue":"2","first_page":"159","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pc4","display_name":"PC4","score":0.9269999861717224},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6800000071525574},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/myoblasts","display_name":"myoblasts","score":0.9369999766349792},{"id":"https://openalex.org/keywords/c2c12-myoblasts","display_name":"C2C12 myoblasts","score":0.9919999837875366},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9129999876022339},{"id":"https://openalex.org/keywords/myogenin","display_name":"myogenin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/myosin","display_name":"myosin","score":0.9459999799728394},{"id":"https://openalex.org/keywords/immediate-early-genes","display_name":"immediate early genes","score":0.5139999985694885},{"id":"https://openalex.org/keywords/antisense-transfection","display_name":"antisense transfection","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C60278653","wikidata":"https://www.wikidata.org/wiki/Q5008075","display_name":"C2C12","level":4,"score":0.8849120736122131},{"id":"https://openalex.org/C97816823","wikidata":"https://www.wikidata.org/wiki/Q166726","display_name":"Myogenin","level":4,"score":0.8449651002883911},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8093875646591187},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6760424375534058},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.6721770167350769},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.5602399706840515},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4889756441116333},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48257818818092346},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43410351872444153},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.21484985947608948},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11925610899925232},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09870690107345581},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08156198263168335}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018008","descriptor_name":"Myogenin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7756174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7756174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Comparative Study"},{"id":"mag:2469178653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7756174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8327000141143799}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W89874917","https://openalex.org/W97496884","https://openalex.org/W1506352984","https://openalex.org/W1514399329","https://openalex.org/W1517928538","https://openalex.org/W1582530932","https://openalex.org/W1583212265","https://openalex.org/W1605704996","https://openalex.org/W1766643663","https://openalex.org/W1884838825","https://openalex.org/W1932210510","https://openalex.org/W1964733862","https://openalex.org/W1965372133","https://openalex.org/W1966387132","https://openalex.org/W1970587959","https://openalex.org/W1970823660","https://openalex.org/W1974543599","https://openalex.org/W1979012059","https://openalex.org/W1983802599","https://openalex.org/W1984767179","https://openalex.org/W1986885306","https://openalex.org/W1987726188","https://openalex.org/W1997322501","https://openalex.org/W2002974644","https://openalex.org/W2013026863","https://openalex.org/W2013046038","https://openalex.org/W2013446898","https://openalex.org/W2014548112","https://openalex.org/W2014669590","https://openalex.org/W2017804863","https://openalex.org/W2019018701","https://openalex.org/W2042458199","https://openalex.org/W2047036794","https://openalex.org/W2050863963","https://openalex.org/W2051313022","https://openalex.org/W2059925029","https://openalex.org/W2076505402","https://openalex.org/W2078718449","https://openalex.org/W2089559330","https://openalex.org/W2094362923","https://openalex.org/W2103735500","https://openalex.org/W2106827676","https://openalex.org/W2115736681","https://openalex.org/W2115991577","https://openalex.org/W2118929543","https://openalex.org/W2122043314","https://openalex.org/W2128940002","https://openalex.org/W2131192326","https://openalex.org/W2134812217","https://openalex.org/W2136690547","https://openalex.org/W2142207422","https://openalex.org/W2269901971"],"related_works":["https://openalex.org/W2005617754","https://openalex.org/W2066318195","https://openalex.org/W2131738138","https://openalex.org/W1998966709","https://openalex.org/W2109424885","https://openalex.org/W2082873926","https://openalex.org/W1940872897","https://openalex.org/W2031458556","https://openalex.org/W1884838825","https://openalex.org/W2118193978"],"abstract_inverted_index":{"PC4":[0,36,81,104,119,135,172],"(pheochromocytoma":[1],"cell-4)":[2],"is":[3,15,38,48,86],"an":[4,145],"immediate":[5],"early":[6],"gene":[7],"related":[8],"to":[9,71,114],"IFN-gamma,":[10],"the":[11,18,28,42,59,97,116,141,161],"mRNA":[12,37],"of":[13,20,61,80,99,118,130,147],"which":[14,95],"induced":[16],"during":[17,50,177],"course":[19],"neuronal":[21],"differentiation":[22,98],"by":[23,88,128],"nerve":[24],"growth":[25,90],"factor":[26,91],"in":[27,41,83,108,120,139,156],"PC12":[29],"cell":[30,45],"line.":[31],"Here":[32],"we":[33],"report":[34],"that":[35],"also":[39,154],"expressed":[40],"myoblast":[43],"C2C12":[44,84,109,157],"line":[46],"and":[47,69,102,149],"regulated":[49],"differentiation;":[51],"its":[52],"expression":[53,82],"decreases":[54],"within":[55,74],"6":[56],"h":[57],"from":[58],"onset":[60],"differentiation,":[62],"attains":[63],"a":[64,93,137,169,174],"minimum":[65],"after":[66],"12":[67],"h,":[68],"returns":[70],"basal":[72],"level":[73],"36":[75],"h.":[76],"This":[77],"transient":[78],"down-regulation":[79],"myoblasts":[85],"prevented":[87],"transforming":[89],"beta,":[92],"molecule":[94],"inhibits":[96],"muscle.":[100],"Sense":[101],"antisense":[103],"cDNA":[105],"transfection":[106],"strategies":[107],"cells":[110,158],"were":[111],"then":[112],"used":[113],"clarify":[115],"role":[117,170],"muscle":[121,178],"differentiation.":[122,179],"While":[123],"no":[124],"effect":[125],"was":[126,153],"seen":[127],"over-expression":[129],"PC4,":[131],"stable":[132],"transfectants":[133],"underexpressing":[134],"exhibited":[136],"delay":[138],"attaining":[140],"differentiated":[142],"phenotype,":[143],"with":[144,160],"impairment":[146],"myogenin":[148],"myosin":[150],"expression.":[151],"Myogenin":[152],"inhibited":[155],"microinjected":[159],"anti-PC4":[162],"polyclonal":[163],"antibody":[164],"A451.":[165],"We":[166],"thus":[167],"postulate":[168],"for":[171],"as":[173],"positive":[175],"regulator":[176]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}