{"id":"https://openalex.org/W2469066751","doi":"https://doi.org/10.1016/j.smim.2016.06.002","title":"Complement inhibition in C3 glomerulopathy","display_name":"Complement inhibition in C3 glomerulopathy","publication_year":2016,"publication_date":"2016-06-01","ids":{"openalex":"https://openalex.org/W2469066751","doi":"https://doi.org/10.1016/j.smim.2016.06.002","mag":"2469066751","pmid":"https://pubmed.ncbi.nlm.nih.gov/27402056"},"language":"en","primary_location":{"id":"doi:10.1016/j.smim.2016.06.002","doi":"https://doi.org/10.1016/j.smim.2016.06.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.smim.2016.06.002","pdf_url":null,"source":{"id":"https://openalex.org/S161731549","display_name":"Seminars in Immunology","issn_l":"1044-5323","issn":["1044-5323","1096-3618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042194566","display_name":"Carla Nester","orcid":"https://orcid.org/0000-0002-0629-7576","observed_orcids":["https://orcid.org/0000-0002-0629-7576"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla M. Nester","raw_affiliation_strings":["Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Divisions of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA","Divisions of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA","Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Divisions of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Divisions of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014833790","display_name":"Richard J. Smith","orcid":"https://orcid.org/0000-0003-1201-6731","observed_orcids":["https://orcid.org/0000-0003-1201-6731"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard J.H. Smith","raw_affiliation_strings":["Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Divisions of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address: richard-smith@uiowa.edu","Divisions of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA","Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Divisions of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address: richard-smith@uiowa.edu","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Divisions of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014833790"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":4370,"currency":"USD","value_usd":4370},"apc_paid":null,"fwci":0.7903,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.60305659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"28","issue":"3","first_page":"241","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.1597999930381775,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c3-glomerulopathy","display_name":"C3 glomerulopathy","score":0.996999979019165},{"id":"https://openalex.org/keywords/complement-inhibition","display_name":"complement inhibition","score":0.8309999704360962},{"id":"https://openalex.org/keywords/complement-dysregulation","display_name":"complement dysregulation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/complement-c3-deposition","display_name":"C3 deposition","score":0.906000018119812},{"id":"https://openalex.org/keywords/glomerular-disease","display_name":"glomerular disease","score":0.8690000176429749},{"id":"https://openalex.org/keywords/disease-classification","display_name":"disease classification","score":0.48399999737739563},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7509999871253967},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2780199430","wikidata":"https://www.wikidata.org/wiki/Q3347169","display_name":"Glomerulopathy","level":4,"score":0.8873814344406128},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.7071300745010376},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.615034818649292},{"id":"https://openalex.org/C133397671","wikidata":"https://www.wikidata.org/wiki/Q3347171","display_name":"Renal pathology","level":3,"score":0.5679724216461182},{"id":"https://openalex.org/C74092355","wikidata":"https://www.wikidata.org/wiki/Q1056943","display_name":"Molecular pathology","level":3,"score":0.49650460481643677},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4743567705154419},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.4712567627429962},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.4271474778652191},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3779065012931824},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3678779602050781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32936161756515503},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.31768298149108887},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22310307621955872},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.1870204210281372},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12915566563606262},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10062679648399353},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0661579966545105},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015433","descriptor_name":"Glomerulonephritis, Membranous","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015433","descriptor_name":"Glomerulonephritis, Membranous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015433","descriptor_name":"Glomerulonephritis, Membranous","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.smim.2016.06.002","doi":"https://doi.org/10.1016/j.smim.2016.06.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.smim.2016.06.002","pdf_url":null,"source":{"id":"https://openalex.org/S161731549","display_name":"Seminars in Immunology","issn_l":"1044-5323","issn":["1044-5323","1096-3618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Immunology","raw_type":"journal-article"},{"id":"pmid:27402056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27402056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W172501607","https://openalex.org/W205927857","https://openalex.org/W268623627","https://openalex.org/W347094963","https://openalex.org/W1534555782","https://openalex.org/W1569990619","https://openalex.org/W1964816580","https://openalex.org/W1965972308","https://openalex.org/W1966820620","https://openalex.org/W1967237155","https://openalex.org/W1969991924","https://openalex.org/W1980344266","https://openalex.org/W1983107482","https://openalex.org/W1983962997","https://openalex.org/W1988891719","https://openalex.org/W1993590923","https://openalex.org/W1995298765","https://openalex.org/W2007500736","https://openalex.org/W2021435063","https://openalex.org/W2022255109","https://openalex.org/W2022763040","https://openalex.org/W2025677314","https://openalex.org/W2038220053","https://openalex.org/W2040189142","https://openalex.org/W2046427044","https://openalex.org/W2056763841","https://openalex.org/W2068933681","https://openalex.org/W2071219763","https://openalex.org/W2074855979","https://openalex.org/W2077144266","https://openalex.org/W2079140345","https://openalex.org/W2090524740","https://openalex.org/W2092372695","https://openalex.org/W2093780976","https://openalex.org/W2096987199","https://openalex.org/W2098613222","https://openalex.org/W2101494871","https://openalex.org/W2102975355","https://openalex.org/W2103573567","https://openalex.org/W2107516496","https://openalex.org/W2114983857","https://openalex.org/W2119057191","https://openalex.org/W2122794090","https://openalex.org/W2123753762","https://openalex.org/W2124330580","https://openalex.org/W2125341483","https://openalex.org/W2125990774","https://openalex.org/W2126299539","https://openalex.org/W2126878361","https://openalex.org/W2134800117","https://openalex.org/W2136648677","https://openalex.org/W2136670693","https://openalex.org/W2138581004","https://openalex.org/W2139588645","https://openalex.org/W2140350573","https://openalex.org/W2143082949","https://openalex.org/W2143620060","https://openalex.org/W2145540059","https://openalex.org/W2149494252","https://openalex.org/W2150267510","https://openalex.org/W2151241196","https://openalex.org/W2154607428","https://openalex.org/W2155315092","https://openalex.org/W2155682255","https://openalex.org/W2167821466","https://openalex.org/W2180897493","https://openalex.org/W2189473737","https://openalex.org/W2198068262","https://openalex.org/W2284643917","https://openalex.org/W2316611324","https://openalex.org/W2328670182","https://openalex.org/W2330016901","https://openalex.org/W4313347715","https://openalex.org/W6607075905"],"related_works":["https://openalex.org/W2063874378","https://openalex.org/W4283312476","https://openalex.org/W4254569804","https://openalex.org/W4389804448","https://openalex.org/W4403848544","https://openalex.org/W2914604561","https://openalex.org/W1999291797","https://openalex.org/W2549792558","https://openalex.org/W2069258445","https://openalex.org/W4403921140"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}