{"id":"https://openalex.org/W2469013752","doi":null,"title":"[Mechanisms of cell death in hypoxic stress].","display_name":"[Mechanisms of cell death in hypoxic stress].","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2469013752","mag":"2469013752","pmid":"https://pubmed.ncbi.nlm.nih.gov/10570775"},"language":"ja","primary_location":{"id":"pmid:10570775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10570775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Geka Gakkai zasshi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H Ura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Ura","raw_affiliation_strings":["First Department of Surgery, Sapporo Medical University, Japan","First Dept. of Surgery, Sapporo Medical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Sapporo Medical University, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"First Dept. of Surgery, Sapporo Medical University, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Hirata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Hirata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001029461","display_name":"T Katsuramaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Katsuramaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.19885528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"100","issue":"10","first_page":"656","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-induced-cell-death","display_name":"hypoxia-induced cell death","score":0.8949999809265137},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.972000002861023},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.7710000276565552},{"id":"https://openalex.org/keywords/death-signaling-pathways","display_name":"death signaling pathways","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.8471158742904663},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.8217615485191345},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8035004734992981},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6752363443374634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5848353505134583},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.580058217048645},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5023009777069092},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.47592857480049133},{"id":"https://openalex.org/C56483683","wikidata":"https://www.wikidata.org/wiki/Q7876087","display_name":"UVB-induced apoptosis","level":5,"score":0.4699689745903015},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41805315017700195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2954816222190857},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.25776946544647217},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2547169625759125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22128775715827942},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12793931365013123},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10329359769821167},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10570775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10570775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Geka Gakkai zasshi","raw_type":"Journal Article"},{"id":"mag:2469013752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10570775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1493701663","https://openalex.org/W42062634","https://openalex.org/W2116199074","https://openalex.org/W2148685097","https://openalex.org/W1994682771","https://openalex.org/W2056695281","https://openalex.org/W1994727872","https://openalex.org/W2033368083","https://openalex.org/W2082654353","https://openalex.org/W2407389652"],"abstract_inverted_index":{"The":[0,146],"present":[1],"article":[2],"attempts":[3],"to":[4,23,46,69,170],"summarize":[5],"and":[6,32,47,74,95,112,133],"introduce":[7],"the":[8,50,100,106,142,176],"mechanisms":[9],"of":[10,28,49,80,99,114,136,166,175,178],"hypoxia-induced":[11,123],"cell":[12,24,34,64,81,89,110,179],"death.":[13,180],"Necrosis":[14],"is":[15,56],"associated":[16],"with":[17],"rapid":[18],"metabolic":[19],"collapse":[20],"that":[21,87,131,148],"leads":[22],"swelling,":[25],"early":[26],"loss":[27],"plasma":[29],"membrane":[30,102],"integrity,":[31],"ultimate":[33],"rupture,":[35],"in":[36,63,109,141],"which":[37,61],"cytosolic":[38],"contents":[39],"leak":[40],"from":[41],"necrotic":[42],"cells":[43,151],"causing":[44],"injury":[45,68],"inflammation":[48],"surrounding":[51,70],"tissue.":[52],"In":[53],"contrast,":[54],"apoptosis":[55,73,96,119,132,153],"an":[57],"energy-requiring,":[58],"gene-directed":[59],"process,":[60],"results":[62],"suicide":[65],"without":[66],"any":[67],"tissues.":[71],"Although":[72],"necrosis":[75,94,124,137,155],"are":[76,156,168],"conceptually":[77],"distinct":[78],"pathways":[79],"death,":[82,111],"recent":[83],"advances":[84],"have":[85],"revealed":[86],"hypoxic":[88],"damage":[90],"can":[91],"induce":[92],"both":[93],"simultaneously.":[97],"Loss":[98],"mitochondrial":[101],"potential":[103],"(MMP)":[104],"precedes":[105],"morphological":[107],"changes":[108],"overexpression":[113],"Bcl-2":[115],"or":[116,154],"Bcl-XL":[117],"blocks":[118],"as":[120,122],"well":[121],"by":[125],"maintaining":[126],"MMP.":[127],"These":[128],"findings":[129],"indicate":[130],"some":[134],"types":[135],"share":[138],"common":[139],"features":[140],"death":[143],"signaling":[144],"pathway.":[145],"factors":[147],"determine":[149],"whether":[150],"undergo":[152],"still":[157],"unclear,":[158],"but":[159],"intracellular":[160],"ATP":[161],"levels":[162],"and/or":[163],"their":[164],"rate":[165],"decline":[167],"considered":[169],"be":[171],"one":[172],"possible":[173],"determinant":[174],"manifestation":[177]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-07-22T00:00:00"}