{"id":"https://openalex.org/W2468949596","doi":null,"title":"Changes of autoantibodies against oxidatively modified low density lipoproteins during long-term LDL-apheresis.","display_name":"Changes of autoantibodies against oxidatively modified low density lipoproteins during long-term LDL-apheresis.","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2468949596","mag":"2468949596","pmid":"https://pubmed.ncbi.nlm.nih.gov/10782563"},"language":"en","primary_location":{"id":"pmid:10782563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10782563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, nutrition & metabolism","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111679573","display_name":"Z. Turk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Z Turk","raw_affiliation_strings":["University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Zagreb Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Zagreb Croatia","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034444078","display_name":"Vladimir Mrzljak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Mrzljak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079160619","display_name":"Nik\u0161a Turk","orcid":"https://orcid.org/0000-0002-0168-9407","observed_orcids":["https://orcid.org/0000-0002-0168-9407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Turk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109048816","display_name":"\u017deljko Metelko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Metelko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"12","issue":"6","first_page":"413","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.05339999869465828,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ldl-apheresis","display_name":"LDL apheresis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ldl-oxidation","display_name":"LDL oxidation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.7929999828338623},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/xanthoma-regression","display_name":"xanthoma regression","score":0.9549999833106995},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.8100000023841858},{"id":"https://openalex.org/keywords/apolipoprotein-a","display_name":"apolipoprotein(a)","score":0.8989999890327454},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.5189999938011169},{"id":"https://openalex.org/keywords/igg-antibody-titres","display_name":"IgG antibody titres","score":0.4259999990463257},{"id":"https://openalex.org/keywords/apheresis-duration","display_name":"apheresis duration","score":0.35499998927116394},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.5339999794960022},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2778751355","wikidata":"https://www.wikidata.org/wiki/Q1797967","display_name":"LDL apheresis","level":4,"score":0.8159452676773071},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.8054527640342712},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.7242971658706665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6384873390197754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6129209995269775},{"id":"https://openalex.org/C2776738589","wikidata":"https://www.wikidata.org/wiki/Q618446","display_name":"Apheresis","level":3,"score":0.5922753810882568},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5657676458358765},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.547390341758728},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.5206671953201294},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.5148833990097046},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5033189654350281},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44250309467315674},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3160422444343567},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.17024284601211548}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006950","descriptor_name":"Hyperlipidemia, Familial Combined","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006950","descriptor_name":"Hyperlipidemia, Familial Combined","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006950","descriptor_name":"Hyperlipidemia, Familial Combined","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10782563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10782563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, nutrition & metabolism","raw_type":"Journal Article"},{"id":"mag:2468949596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10782563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2902046180","doi":null,"is_oa":false,"landing_page_url":"https://www.bib.irb.hr/38003","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2902046180","https://openalex.org/W2750370527","https://openalex.org/W2761513705","https://openalex.org/W2341810545","https://openalex.org/W2117261917","https://openalex.org/W2086923723","https://openalex.org/W1986491900","https://openalex.org/W2316642208","https://openalex.org/W2050361173","https://openalex.org/W1979905860"],"abstract_inverted_index":{"The":[0,16,57,87,107,277],"oxidation":[1,31],"of":[2,14,18,27,60,89,118,173,181,185,200,218,274,279,292],"low-density":[3],"lipoproteins":[4],"(LDL)":[5],"is":[6],"considered":[7,79],"a":[8,81,198,289],"key":[9],"event":[10],"in":[11,28,168,191,197],"the":[12,24,85,101,166,183,216,286,293],"initiation":[13],"atherosclerosis.":[15],"aim":[17],"this":[19,169],"study":[20,102,269],"was":[21,52,98,176,189,283],"to":[22,84,165,193],"follow-up":[23],"biological":[25],"marker":[26],"vivo":[29],"LDL":[30,34,95,240],"(oxidatively":[32],"modified":[33,94],"autoantibody":[35],"titres)":[36],"during":[37,285],"long-term":[38],"LDL-apheresis":[39,49,275],"treatment.":[40,86],"A":[41],"patient":[42],"suffering":[43],"from":[44],"severe":[45],"combined":[46],"hyperlipidaemia":[47],"underwent":[48],"biweekly":[50],"and":[51,73,103,222],"followed":[53,99],"for":[54],"two":[55],"years.":[56],"significant":[58],"reduction":[59],"baseline":[61],"total":[62,65,227],"cholesterol":[63,228,241,248],"(58%),":[64],"triglycerides":[66,234],"(80%),":[67],"LDL-cholesterol":[68],"(48%),":[69],"apoprotein":[70],"B":[71,255],"(50%)":[72],"apolipoprotein":[74],"(a)":[75,262],"(61%)":[76],"may":[77],"be":[78],"as":[80,113],"good":[82],"response":[83],"titre":[88,195,217],"autoantibodies":[90,219,280],"(IgG)":[91],"against":[92,220,281],"oxidatively":[93],"(malondialdehyde-derived":[96],"LDL)":[97],"throughout":[100],"showed":[104,223,270],"dynamic":[105],"changes.":[106],"measured":[108],"values":[109],"were":[110,213],"multiple":[111],"compared":[112],"mean+/-SD":[114],"over":[115],"each":[116],"semester":[117,122,129,136,141,151,156,161],"apheresis":[119],"application:":[120],"I":[121,148],"70.0+/-8.3":[123],"U/ml,":[124,131,138,143],"n":[125,132,144],"=":[126,133,145,206,232,238,245,252,259,266],"12;":[127,134,146],"II":[128,150,153],"58.0+/-13.8":[130],"III":[135,155,158],"37.6+/-6.0":[137],"n=12;":[139],"IV":[140,160],"34.3+/-7.0":[142],"ANOVA:":[147],"vs.":[149,154,159,229,235,242,249,256,263],"p<0.083,":[152],"p<0.00053,":[157],"p<0.248.":[162],"In":[163,179],"parallel":[164],"changes":[167],"biochemical":[170],"parameter,":[171],"regression":[172],"numerous":[174],"xanthomas":[175],"clinically":[177],"observed.":[178],"spite":[180],"this,":[182],"presence":[184],"oxidised-LDL":[186],"(oxLDL)":[187],"antibodies":[188],"enhanced":[190],"comparison":[192],"antibody":[194],"detected":[196],"group":[199],"age-matched":[201],"normolipaemic":[202],"healthy":[203],"controls":[204],"(n":[205],"15;":[207],"19.4+/-8.6;":[208],"p<0.01).":[209],"Classical":[210],"lipoprotein":[211],"parameters":[212],"correlated":[214],"with":[215],"oxLDL":[221,282],"low":[224],"correlation":[225],"coefficients:":[226],"oxLDLab,":[230,236,243,250,257,264],"r":[231,237,244,251,258,265],"0.36;":[233],"0.43;":[239],"0.14;":[246],"HDL":[247],"-0.33;":[253],"apo":[254,261],"0.25;":[260],"-0.05.":[267],"Our":[268],"an":[271],"additional":[272],"benefit":[273],"therapy.":[276],"production":[278],"reduced":[284],"treatment,":[287],"indicating":[288],"lower":[290],"level":[291],"atherogenic":[294],"antigen.":[295]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}