{"id":"https://openalex.org/W2468464956","doi":"https://doi.org/10.1016/s0022-5347(17)36546-1","title":"Collagen and Bladder Function in Streptozotocin-Diabetic Rats: Effects of Insulin and Aminoguanidine","display_name":"Collagen and Bladder Function in Streptozotocin-Diabetic Rats: Effects of Insulin and Aminoguanidine","publication_year":1992,"publication_date":"1992-07-01","ids":{"openalex":"https://openalex.org/W2468464956","doi":"https://doi.org/10.1016/s0022-5347(17)36546-1","mag":"2468464956","pmid":"https://pubmed.ncbi.nlm.nih.gov/1535382"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)36546-1","doi":"https://doi.org/10.1016/s0022-5347(17)36546-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)36546-1","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045336219","display_name":"Berit \u0395ika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Berit Eika","raw_affiliation_strings":["Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania","From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark","Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042687042","display_name":"Robert M. Levin","orcid":"https://orcid.org/0000-0003-1578-6870","observed_orcids":["https://orcid.org/0000-0003-1578-6870"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Robert M. Levin","raw_affiliation_strings":["Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania","From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark","Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2799810409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112100529","display_name":"Penelope A. Longhurst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Penelope A. Longhurst","raw_affiliation_strings":["Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania","From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark","Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; From the Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2799810409"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":3.0228,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.92464539,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"148","issue":"1","first_page":"167","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.15760000050067902,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.6809999942779541},{"id":"https://openalex.org/keywords/bladder-function","display_name":"bladder function","score":0.9480000138282776},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8080000281333923},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/aminoguanidine","display_name":"aminoguanidine","score":1.0},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9620000123977661},{"id":"https://openalex.org/keywords/length-tension-relationship","display_name":"length-tension relationship","score":0.7720000147819519},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.816077470779419},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.722876787185669},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7117687463760376},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5771991014480591},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5600783228874207},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.5564889907836914},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48297443985939026},{"id":"https://openalex.org/C179687394","wikidata":"https://www.wikidata.org/wiki/Q4826281","display_name":"Autofluorescence","level":3,"score":0.4539581835269928},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4397158622741699},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.41251420974731445},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1814795732498169},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1477767825126648},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-5347(17)36546-1","doi":"https://doi.org/10.1016/s0022-5347(17)36546-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)36546-1","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:1535382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1535382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/1f5bf9ed-12f9-486d-8c1e-989f84ff9c1b","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/1f5bf9ed-12f9-486d-8c1e-989f84ff9c1b","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eika, B, Levin, R M & Longhurst, P A 1992, 'Collagen and bladder function in stretozotocin-diabetic rats : effects of insulin and aminoguandine', J. Urol., vol. 148, pp. 167-172.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G124642987","display_name":"METABOLIC REGULATION OF URINARY BLADDER FUNCTION","funder_award_id":"R01DK033559","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2543615451","display_name":null,"funder_award_id":"DK 41610","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1556333628","https://openalex.org/W1564784842","https://openalex.org/W1566830427","https://openalex.org/W1976068063","https://openalex.org/W1978421101","https://openalex.org/W2008729040","https://openalex.org/W2028070036","https://openalex.org/W2029815876","https://openalex.org/W2032055976","https://openalex.org/W2034462747","https://openalex.org/W2035508902","https://openalex.org/W2042598400","https://openalex.org/W2043397658","https://openalex.org/W2057921787","https://openalex.org/W2075800553","https://openalex.org/W2090421214","https://openalex.org/W2098513539","https://openalex.org/W2109966264","https://openalex.org/W2112660114","https://openalex.org/W2128921346","https://openalex.org/W2144732441","https://openalex.org/W2315359754","https://openalex.org/W2330440631","https://openalex.org/W2337292567","https://openalex.org/W2396304323","https://openalex.org/W2398421370","https://openalex.org/W2404112754","https://openalex.org/W2405292153","https://openalex.org/W2412858907","https://openalex.org/W2439636577","https://openalex.org/W4240373434"],"related_works":["https://openalex.org/W7134867353","https://openalex.org/W2591065648","https://openalex.org/W1964363743","https://openalex.org/W2388278809","https://openalex.org/W7097024449","https://openalex.org/W2084126217","https://openalex.org/W2035508902","https://openalex.org/W2000290630","https://openalex.org/W3098609990","https://openalex.org/W4254523290"],"abstract_inverted_index":{"The":[0,46,122],"effects":[1],"of":[2,32,49,66,73,92,97,128,152,163,181,189,198,207,251,277],"insulin":[3,237],"(5":[4],"U/day":[5],"subcutaneously":[6],"for":[7,16,281],"60":[8,17],"days)":[9,18],"and":[10,29,69,88,116,125,168,200,222,230],"aminoguanidine":[11,157,242],"(25":[12],"mg./kg./day":[13],"via":[14],"gavage":[15],"on":[19],"collagen":[20,123,129,178,249],"concentration,":[21],"resistance":[22,169],"to":[23,55,76,149,170,195],"enzymatic":[24,132,171],"digestion":[25,133,172],"with":[26,107,114,120],"Pronase":[27],"E,":[28],"the":[30,126,136,153,182,196,248,252,264,271,275],"accumulation":[31,162],"advanced":[33,57,164],"glycosylation":[34,58,165],"end":[35,59,166],"products":[36,167],"in":[37,42,64,78,141,161,177,203,212,228,256,261,263],"bladder":[38,67,79,86,93,183,190,232,253,282],"tissue":[39,52,68,138],"were":[40,100,234],"studied":[41],"male":[43],"streptozotocin-diabetic":[44],"rats.":[45,145,205],"characteristic":[47],"autofluorescence":[48,139],"glycosylated":[50],"connective":[51,137],"was":[53,62,81,147,192],"used":[54],"quantitate":[56],"products.":[60],"Fluorescence":[61],"measured":[63,185],"digests":[65],"expressed":[70],"as":[71,184,258,260],"fluorescence/micrograms.":[72],"hydroxyproline.":[74],"Correlation":[75],"alterations":[77],"function":[80,233],"made":[82],"by":[83,131,186,236,241],"studying":[84],"in-vivo":[85,229],"micturition":[87,214,220],"in-vitro":[89,231],"length-tension":[90,187],"relations":[91,188],"strips.":[94],"Five":[95],"groups":[96],"age-matched":[98],"rats":[99],"studied:":[101],"1)":[102],"controls,":[103],"2)":[104],"controls":[105],"treated":[106,113,119],"aminoguanidine,":[108,115],"3)":[109],"diabetics,":[110],"4)":[111],"diabetics":[112,118],"5)":[117],"insulin.":[121],"concentration":[124],"amount":[127,197,257],"released":[130],"decreased":[134],"while":[135,156],"increased":[140,202],"bladders":[142],"from":[143],"diabetic":[144,204,265],"Insulin":[146],"able":[148],"prevent":[150],"all":[151],"observed":[154],"changes":[155,160,176,255],"protected":[158],"against":[159,175],"but":[173,239],"not":[174,240],"concentration.":[179],"Stretchability":[180],"strips":[191],"inversely":[193],"proportional":[194],"collagen,":[199,278],"therefore":[201],"Diabetes":[206],"two":[208],"months":[209],"duration":[210],"resulted":[211],"altered":[213],"pattern":[215],"(increased":[216],"fluid":[217],"consumption,":[218],"diuresis,":[219],"frequency,":[221],"average":[223],"volume":[224],"per":[225],"micturition).":[226],"Alterations":[227],"prevented":[235],"treatment":[238],"treatment.":[243],"We":[244],"have":[245],"shown":[246],"that":[247,270],"component":[250],"wall":[254],"well":[259],"quality":[262],"rat.":[266],"Our":[267],"data":[268],"suggest":[269],"amount,":[272],"rather":[273],"than":[274],"properties":[276],"is":[279],"important":[280],"function.":[283]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-07-22T00:00:00"}