{"id":"https://openalex.org/W2468072018","doi":"https://doi.org/10.1016/j.jalz.2015.06.525","title":"P1\u2010310: Suvn\u2010g3031, an h3 receptor inverse agonist, produces procognitive effects without affecting sleep in preclinical models","display_name":"P1\u2010310: Suvn\u2010g3031, an h3 receptor inverse agonist, produces procognitive effects without affecting sleep in preclinical models","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W2468072018","doi":"https://doi.org/10.1016/j.jalz.2015.06.525","mag":"2468072018"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2015.06.525","doi":"https://doi.org/10.1016/j.jalz.2015.06.525","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2015.06.525","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040007646","display_name":"Vijay S. Benade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vijay S. Benade","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025725725","display_name":"Saivishal Daripelli","orcid":"https://orcid.org/0000-0002-7995-8814","observed_orcids":["https://orcid.org/0000-0002-7995-8814"]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saivishal Daripelli","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031141885","display_name":"Jagadeesh Babu Thentu","orcid":"https://orcid.org/0000-0002-1840-5263","observed_orcids":["https://orcid.org/0000-0002-1840-5263"]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jagadeesh Babu Thentu","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109202977","display_name":"Arunkumar Manoharan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arunkumar Manoharan","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079038535","display_name":"Rajesh Babu Medapati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajesh Babu Medapati","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112686504","display_name":"Ramkumar Subramanian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramkumar Subramanian","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059610421","display_name":"Venkat Reddy Mekala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Venkat Reddy Mekala","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103844324","display_name":"Anil Karbhari Shinde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anil K. Shinde","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059481166","display_name":"Rajesh Kumar Badange","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajesh Kumar Badange","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040508823","display_name":"Vinod Goyal","orcid":"https://orcid.org/0000-0002-7325-1914","observed_orcids":["https://orcid.org/0000-0002-7325-1914"]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vinod Kumar Goyal","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101551569","display_name":"Santosh Kumar Pandey","orcid":"https://orcid.org/0000-0003-1753-0051","observed_orcids":["https://orcid.org/0000-0003-1753-0051"]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Santosh Kumar Pandey","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050284513","display_name":"Ramakrishna V. S. Nirogi","orcid":"https://orcid.org/0000-0002-2045-0784","observed_orcids":["https://orcid.org/0000-0002-2045-0784"]},"institutions":[{"id":"https://openalex.org/I4210097346","display_name":"Suven Life Sciences (India)","ror":"https://ror.org/01p9aw348","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210097346"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramakrishna Nirogi","raw_affiliation_strings":["Suven Life Sciences Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suven Life Sciences Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210097346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040007646"],"corresponding_institution_ids":["https://openalex.org/I4210097346"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.3485,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.47930639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"7S_Part_10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.29030001163482666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.29030001163482666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.24959999322891235,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.10760000348091125,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C63180777","wikidata":"https://www.wikidata.org/wiki/Q288395","display_name":"Histamine H3 receptor","level":4,"score":0.65965336561203},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.6182457804679871},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5914105176925659},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5692012310028076},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5439971685409546},{"id":"https://openalex.org/C89951826","wikidata":"https://www.wikidata.org/wiki/Q1671731","display_name":"Inverse agonist","level":4,"score":0.49445152282714844},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.44013741612434387},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42386019229888916},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3995404839515686},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39378610253334045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3042748272418976},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29544031620025635},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2566680312156677},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.14477550983428955}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2015.06.525","doi":"https://doi.org/10.1016/j.jalz.2015.06.525","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2015.06.525","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2008404870","https://openalex.org/W2161764141","https://openalex.org/W2065668260","https://openalex.org/W2537013089","https://openalex.org/W2090151453","https://openalex.org/W2038906622","https://openalex.org/W2908929771","https://openalex.org/W2596568665","https://openalex.org/W3127406149","https://openalex.org/W2170266710"],"abstract_inverted_index":{"Histamine":[0],"H3":[1,36,84,184,236],"receptors":[2],"play":[3],"a":[4,8],"critical":[5],"role":[6],"as":[7],"neuromodulator":[9],"through":[10],"its":[11],"widespread":[12],"distribution":[13],"in":[14,41,71,83,112,131,138,201,213,227,235,242,251,262,273,276,290,299,306,324,331,342],"the":[15,24,48,123,150,166,252,263,310,335],"central":[16],"nervous":[17],"system.":[18],"Blockade":[19],"of":[20,27,44,51,92,105,125,134,149,155,267,281,340],"this":[21],"receptor":[22,37,69,237],"augments":[23],"pre-synaptic":[25],"release":[26],"histamine":[28,108,249],"and":[29,62,89,99,109,142,158,174,186,197,203,244,248,283,295,312,316,338],"other":[30],"neurotransmitters":[31],"including":[32],"acetylcholine.":[33],"Currently,":[34],"several":[35],"antagonists/inverse":[38],"agonists":[39],"are":[40,330],"different":[42],"stages":[43],"clinical":[45],"trials":[46],"for":[47,75,320],"potential":[49],"treatment":[50],"narcolepsy,":[52],"cognitive":[53],"impairments":[54],"associated":[55],"with":[56,153,278],"Alzheimer's":[57],"disease,":[58,60],"Parkinson's":[59],"schizophrenia":[61],"attention":[63],"deficit":[64,212,226],"hyperactivity":[65],"disorder.":[66],"In":[67,143],"vivo":[68],"occupancy":[70,238],"rats":[72,243,307],"was":[73,81,114,119,136,270,284],"evaluated":[74,82,137],"SUVN-G3031":[76,80,106,126,135,146,169,191,206,258,269,302,341],"using":[77,116],"non-radiolabled":[78],"tracer.":[79],"agonist":[85],"induced":[86,194,210,224],"dipsogenia":[87],"assay,":[88],"rat":[90],"models":[91],"cognition":[93],"like":[94],"object":[95,214],"recognition":[96,215],"task,":[97],"T-maze":[98,218],"Morris":[100,228],"water":[101,195,229],"maze":[102,230],"task.":[103,219,231],"Effect":[104],"on":[107,127],"acetylcholine":[110,247],"modulation":[111],"brain":[113,175,202],"studied":[115],"microdialysis.":[117],"Electroencephalography":[118],"used":[120],"to":[121,240,286,333],"study":[122],"effects":[124,305],"wake":[128,265],"promoting":[129],"activity":[130],"rats.":[132,268],"Safety":[133],"rodents/":[139],"non":[140,288],"rodents":[141],"vitro":[144],"models.":[145],"is":[147],"one":[148],"lead":[151],"molecule":[152,178],"hKi":[154],"8.7":[156],"nM":[157],"has":[159],"more":[160],"than":[161],"100":[162],"fold":[163],"selectivity":[164],"against":[165],"related":[167],"GPCRs.":[168],"exhibited":[170,179],"desired":[171,317],"pharmacokinetic":[172,318],"property":[173],"penetration.":[176],"This":[177],"an":[180],"excellent":[181],"separation":[182],"between":[183],"affinity":[185],"hERG":[187],"ion":[188],"channel":[189],"inhibition.":[190],"blocked":[192],"R-\u03b1-methylhistamine":[193],"intake":[196],"increased":[198],"tele-methylhistamine":[199],"levels":[200,250],"cerebrospinal":[204],"fluid.":[205],"significantly":[207,245],"reversed":[208,222],"time":[209],"memory":[211,225],"test":[216,298],"&":[217],"It":[220],"also":[221],"scopolamine":[223],"Oral":[232],"administration":[233],"resulted":[234],"up":[239],"85%":[241],"raised":[246],"cortex.":[253],"At":[254],"therapeutically":[255],"effective":[256],"doses,":[257],"produced":[259,303],"no":[260],"change":[261],"sleep/":[264],"profile":[266,319],"well":[271],"tolerated":[272],"toxicity":[274],"studies":[275,329],"animals":[277],"wide":[279],"margin":[280],"safety,":[282,336],"found":[285],"be":[287],"genotoxic":[289],"bacterial":[291],"reverse":[292],"mutation":[293],"assay":[294],"chromosomal":[296],"aberration":[297],"human":[300,345],"lymphocytes.":[301],"procognitive":[304],"without":[308],"affecting":[309],"sleep":[311],"it":[313],"possess":[314],"safety":[315],"further":[321],"development.":[322],"First":[323],"human,":[325],"US":[326],"IND":[327],"Phase-I":[328],"progress":[332],"evaluate":[334],"tolerability":[337],"pharmacokinetics":[339],"healthy":[343],"adult":[344],"volunteers.":[346]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-07-22T00:00:00"}