{"id":"https://openalex.org/W2468069443","doi":null,"title":"Diabetic nephropathy in the rat: differing renal effects of an angiotensin converting enzyme inhibitor and a calcium inhibitor.","display_name":"Diabetic nephropathy in the rat: differing renal effects of an angiotensin converting enzyme inhibitor and a calcium inhibitor.","publication_year":1988,"publication_date":"1988-06-01","ids":{"openalex":"https://openalex.org/W2468069443","mag":"2468069443","pmid":"https://pubmed.ncbi.nlm.nih.gov/2852570"},"language":"en","primary_location":{"id":"pmid:2852570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2852570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes research (Edinburgh, Scotland)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020638253","display_name":"M. Whitty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M R Whitty","raw_affiliation_strings":["Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108440184","display_name":"B. Jackson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Jackson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6628,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.82049307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"2","first_page":"91","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":1.0},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/enalapril","display_name":"enalapril","score":0.9160000085830688},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.9449999928474426},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":1.0},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9229999780654907},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.8259999752044678},{"id":"https://openalex.org/keywords/renal-blood-pressure","display_name":"renal blood pressure","score":0.5669999718666077},{"id":"https://openalex.org/keywords/filtration-fraction","display_name":"filtration fraction","score":0.6890000104904175},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.8429999947547913},{"id":"https://openalex.org/keywords/unilateral-nephrectomy","display_name":"unilateral nephrectomy","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2775940317","wikidata":"https://www.wikidata.org/wiki/Q422185","display_name":"Enalapril","level":4,"score":0.8479928374290466},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7681752443313599},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7554254531860352},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7161687612533569},{"id":"https://openalex.org/C119584498","wikidata":"https://www.wikidata.org/wiki/Q5449277","display_name":"Filtration fraction","level":4,"score":0.6857016086578369},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.628576397895813},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.6175205111503601},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5768380761146545},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.5652729272842407},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.5408580303192139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5090886950492859},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4894057810306549},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.4847557246685028},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4769424498081207},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.45384377241134644},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4329882264137268},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3428648114204407},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.2649359107017517},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.2030368149280548}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004656","descriptor_name":"Enalapril","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2852570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2852570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes research (Edinburgh, Scotland)","raw_type":"Journal Article"},{"id":"mag:2468069443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2852570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2084447309","https://openalex.org/W2080991684","https://openalex.org/W1982039761","https://openalex.org/W2051178050","https://openalex.org/W2135845657","https://openalex.org/W1989009537","https://openalex.org/W2159312282","https://openalex.org/W2053762239","https://openalex.org/W2073935745","https://openalex.org/W2395650639"],"abstract_inverted_index":{"The":[0,209],"renal":[1,217],"functional":[2],"alterations":[3],"that":[4,172],"occurred":[5,219],"in":[6,9,157],"streptozotocin-induced":[7],"diabetes":[8],"uninephrectomized":[10],"rats":[11,61,101,160,182],"were":[12,102],"studied":[13],"over":[14],"a":[15,63],"three-month":[16],"period.":[17],"Diabetic":[18,100],"animals":[19],"had":[20,62,202],"elevated":[21],"systemic":[22],"systolic":[23,35,64,112],"blood":[24,36,65,113],"pressure,":[25],"creatinine":[26,43,76],"clearance":[27,44,77],"and":[28,50,87,124,214,225],"urinary":[29,51],"protein":[30,52,88],"excretion.":[31],"After":[32],"three":[33,143,168],"months,":[34,169],"pressure":[37,66,114],"was":[38,45,161,183],"131":[39],"+/-":[40,47,55,69,80,92,117,126,146,163,185,194,207],"2":[41,127],"mmHg,":[42],"1.52":[46],"0.06":[48],"ml/min":[49,82],"excretion":[53,89,155],"70.8":[54],"17.9":[56],"mg/24":[57,94,148,165],"h.":[58],"Non-diabetic":[59],"control":[60],"of":[67,78,90,140,173,179,212,223,233],"117":[68],"3":[70,118],"mmHg":[71,119,128],"(p":[72,83,96,120,129],"less":[73,84,97,121,130,151,197],"than":[74,85,98,122,131,152,198],"0.001),":[75,86],"1.15":[79],"0.05":[81],"8.22":[91],"0.2":[93],"h":[95,166],"0.001).":[99],"treated":[103,159],"with":[104,135,188],"enalapril":[105,136,189,213],"or":[106],"verapamil,":[107],"5":[108],"mg.kg-1.day-1":[109],"which":[110],"reduced":[111,137],"to":[115,171],"108":[116],"0.001)":[123,132],"114":[125],"respectively.":[133],"Treatment":[134,187],"the":[138,228],"degree":[139],"proteinuria":[141],"at":[142,167],"months":[144],"(36.4":[145],"3.0":[147],"h,":[149],"p":[150,196],"0.05).":[153],"Protein":[154],"rate":[156],"verapamil":[158,201,215],"57.7":[162],"10.1":[164],"similar":[170,221],"untreated":[174,180],"diabetic":[175,181],"rats.":[176],"Filtration":[177],"fraction":[178,192],"0.40":[184],"0.04.":[186],"lowered":[190],"filtration":[191],"(0.26":[193],"0.02,":[195],"0.01)":[199],"whilst":[200],"no":[203],"significant":[204],"effect":[205],"(0.37":[206],"0.02).":[208],"differing":[210],"effects":[211,232],"on":[216],"function":[218],"despite":[220],"degrees":[222],"hypotension,":[224],"may":[226],"reflect":[227],"different":[229],"intrarenal":[230],"haemodynamic":[231],"these":[234],"drugs.":[235]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
