{"id":"https://openalex.org/W2467997710","doi":null,"title":"The role of excitotoxicity and metabolic failure in the pathogenesis of neurological disorders.","display_name":"The role of excitotoxicity and metabolic failure in the pathogenesis of neurological disorders.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2467997710","mag":"2467997710","pmid":"https://pubmed.ncbi.nlm.nih.gov/9713834"},"language":"en","primary_location":{"id":"pmid:9713834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9713834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology (Budapest, Hungary)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090539793","display_name":"Lourdes Massieu","orcid":"https://orcid.org/0000-0001-6057-4231","observed_orcids":["https://orcid.org/0000-0001-6057-4231"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"L Massieu","raw_affiliation_strings":["Departamento de Neurociencias, Instituto de Fisiolog\u00eda Celular, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico, DF","Departamento de Neurociencias, Instituto de Fisiolog\u00eda Celular, Universidad Nacional Aut\u00f3noma de Mexico, Mexico DF"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Neurociencias, Instituto de Fisiolog\u00eda Celular, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico, DF","institution_ids":["https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Neurociencias, Instituto de Fisiolog\u00eda Celular, Universidad Nacional Aut\u00f3noma de Mexico, Mexico DF","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"last","author":{"id":null,"display_name":"O Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Garc\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2356,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.46875443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"1","first_page":"99","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.9449999928474426},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hypoxic-ischemic-brain-injury","display_name":"hypoxic-ischemic brain injury","score":0.7789999842643738},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nmda-receptor-activation","display_name":"NMDA receptor activation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.8159999847412109},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7059999704360962},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.7519999742507935},{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ion-gradients","display_name":"ion gradients","score":0.6779999732971191},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.9496145248413086},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.8929237127304077},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7359753251075745},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.6052229404449463},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4794858396053314},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.46999797224998474},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.44171392917633057},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.43067386746406555},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4057430624961853},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4007418155670166},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3882290720939636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37441784143447876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31610098481178284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2311340868473053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20649763941764832},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.13194572925567627}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027322","descriptor_name":"Amino Acid Transport System X-AG","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9713834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9713834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology (Budapest, Hungary)","raw_type":"Journal Article"},{"id":"mag:2467997710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9713834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2152985670","https://openalex.org/W1999379012","https://openalex.org/W2124548597","https://openalex.org/W119562113","https://openalex.org/W1983651051","https://openalex.org/W1972591818","https://openalex.org/W2012576004","https://openalex.org/W567189545","https://openalex.org/W2088831200","https://openalex.org/W4230991046"],"abstract_inverted_index":{"Glutamate":[0,86],"neurotoxicity":[1],"has":[2,32],"been":[3,33,58],"implicated":[4],"in":[5,13,60,90,106],"acute":[6],"neurological":[7],"disorders":[8],"such":[9,17],"as":[10,18],"ischemia,":[11],"and":[12,27,53,81],"chronic":[14],"neurodegenerative":[15],"diseases":[16],"Huntington's":[19],"disease":[20],"(HD).":[21],"Recently,":[22],"a":[23,95],"link":[24],"between":[25],"excitotoxicity":[26],"impairment":[28,77],"of":[29,45,64,70,78,83,110],"energy":[30],"metabolism":[31,71],"proposed.":[34],"Important":[35],"evidence":[36],"suggests":[37],"that":[38],"metabolic":[39,49,55],"inhibition":[40,69],"exacerbates":[41],"the":[42,65,111],"toxic":[43],"effect":[44],"glutamate.":[46],"During":[47],"hypoxic/ischemia":[48],"disturbances":[50],"are":[51],"obvious,":[52],"several":[54],"defects":[56],"have":[57],"found":[59],"HD":[61],"patients.":[62],"Disruption":[63],"ionic":[66],"gradients":[67],"during":[68],"can":[72],"lead":[73],"to":[74,99,118],"glutamate":[75,79,116],"release,":[76],"transport,":[80],"activation":[82,88],"NMDA":[84],"receptors.":[85],"receptor":[87],"results":[89,105],"calcium":[91,112],"influx":[92],"which":[93],"is":[94],"determinant":[96],"step":[97],"leading":[98],"cell":[100,119],"death.":[101,120],"Additionally":[102],"mitochondrial":[103],"failure":[104],"an":[107],"inadequate":[108],"buffering":[109],"load":[113],"induced":[114],"by":[115],"contributing":[117]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}