{"id":"https://openalex.org/W2467960033","doi":"https://doi.org/10.1126/science.aaf5605","title":"A maleness gene in the malaria mosquito Anopheles gambiae","display_name":"A maleness gene in the malaria mosquito Anopheles gambiae","publication_year":2016,"publication_date":"2016-06-30","ids":{"openalex":"https://openalex.org/W2467960033","doi":"https://doi.org/10.1126/science.aaf5605","mag":"2467960033","pmid":"https://pubmed.ncbi.nlm.nih.gov/27365445"},"language":"en","primary_location":{"id":"doi:10.1126/science.aaf5605","doi":"https://doi.org/10.1126/science.aaf5605","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.aaf5605","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052136942","display_name":"Elzbieta Krzywi\u0144ska","orcid":"https://orcid.org/0000-0002-0337-0782","observed_orcids":["https://orcid.org/0000-0002-0337-0782"]},"institutions":[{"id":"https://openalex.org/I1287548271","display_name":"The Pirbright Institute","ror":"https://ror.org/04xv01a59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1287548271","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Elzbieta Krzywinska","raw_affiliation_strings":["The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK","institution_ids":["https://openalex.org/I1287548271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109335517","display_name":"Nathan J. Dennison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"funder","lineage":["https://openalex.org/I194839184"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nathan J. Dennison","raw_affiliation_strings":["Department of Life Sciences, Imperial College, South Kensington Campus, London SW7 2AZ, UK","Vector Biology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Imperial College, South Kensington Campus, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Vector Biology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK","institution_ids":["https://openalex.org/I194839184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049461959","display_name":"Gareth John Lycett","orcid":"https://orcid.org/0000-0002-2422-053X","observed_orcids":["https://orcid.org/0000-0002-2422-053X"]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"funder","lineage":["https://openalex.org/I194839184"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth J. Lycett","raw_affiliation_strings":["Vector Biology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vector Biology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK","institution_ids":["https://openalex.org/I194839184"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052864102","display_name":"Jaroslaw Krzywinski","orcid":"https://orcid.org/0000-0001-6363-9790","observed_orcids":["https://orcid.org/0000-0001-6363-9790"]},"institutions":[{"id":"https://openalex.org/I1287548271","display_name":"The Pirbright Institute","ror":"https://ror.org/04xv01a59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1287548271","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"funder","lineage":["https://openalex.org/I194839184"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jaroslaw Krzywinski","raw_affiliation_strings":["The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK","Vector Biology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK","institution_ids":["https://openalex.org/I1287548271"]},{"raw_affiliation_string":"Vector Biology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK","institution_ids":["https://openalex.org/I194839184"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052136942","https://openalex.org/A5052864102","https://openalex.org/A5109335517"],"corresponding_institution_ids":["https://openalex.org/I1287548271","https://openalex.org/I194839184","https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":7.1974,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.97690516,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"353","issue":"6294","first_page":"67","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anopheles-gambiae","display_name":"Anopheles gambiae","score":0.8790000081062317},{"id":"https://openalex.org/keywords/m-factor","display_name":"M factor","score":0.7170000076293945},{"id":"https://openalex.org/keywords/sex-determination","display_name":"sex determination","score":0.828000009059906},{"id":"https://openalex.org/keywords/doublesex-gene","display_name":"doublesex gene","score":0.6570000052452087},{"id":"https://openalex.org/keywords/y-chromosome","display_name":"Y chromosome","score":0.5960000157356262},{"id":"https://openalex.org/keywords/male-lethality","display_name":"male lethality","score":0.7760000228881836},{"id":"https://openalex.org/keywords/malaria-vector-control","display_name":"malaria vector control","score":0.7770000100135803},{"id":"https://openalex.org/keywords/sex-linked-genes","display_name":"sex-linked genes","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C2776802408","wikidata":"https://www.wikidata.org/wiki/Q135237","display_name":"Anopheles gambiae","level":3,"score":0.8981132507324219},{"id":"https://openalex.org/C2776514529","wikidata":"https://www.wikidata.org/wiki/Q5300147","display_name":"Doublesex","level":5,"score":0.8842774629592896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8768970966339111},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6131700277328491},{"id":"https://openalex.org/C2781375639","wikidata":"https://www.wikidata.org/wiki/Q158597","display_name":"Anopheles","level":3,"score":0.6027082204818726},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.6019105315208435},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5662881135940552},{"id":"https://openalex.org/C2778060650","wikidata":"https://www.wikidata.org/wiki/Q22964789","display_name":"Gene drive","level":4,"score":0.4721149206161499},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.44488224387168884},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.35469672083854675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3249672055244446},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1290389597415924},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0920683741569519},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.06405258178710938}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000852","descriptor_name":"Anopheles","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D000852","descriptor_name":"Anopheles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007303","descriptor_name":"Insect Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014998","descriptor_name":"Y Chromosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019849","descriptor_name":"Sex Determination Processes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/science.aaf5605","doi":"https://doi.org/10.1126/science.aaf5605","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.aaf5605","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:27365445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27365445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:archive.lstmed.ac.uk:5963","doi":null,"is_oa":false,"landing_page_url":"https://archive.lstmed.ac.uk/5963/1/Krzywinska_science_manuscript_word_accepted.docx","pdf_url":null,"source":{"id":"https://openalex.org/S4306400185","display_name":"LSTM Online Archive (Liverpool School of Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I194839184","host_organization_name":"Liverpool School of Tropical Medicine","host_organization_lineage":["https://openalex.org/I194839184"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1324307114","display_name":"Deciphering molecular basis of mosquito development and vectorial capacity to facilitate novel approaches to vector-borne disease control","funder_award_id":"BBS/E/I/00001854","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2172582759","display_name":"Post Genomic Functional Genetic Analysis of Parasite/Insect Interaction","funder_award_id":"BB/F021933/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4420149952","display_name":null,"funder_award_id":"HHSN272200900039C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5963564278","display_name":null,"funder_award_id":"HHSN272200900039C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8356105870","display_name":null,"funder_award_id":"CRSC120816JKUND","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G9000005735","display_name":null,"funder_award_id":"089045/Z/09/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320315463","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84"},{"id":"https://openalex.org/F4320320354","display_name":"Pirbright Institute","ror":"https://ror.org/04xv01a59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W89248094","https://openalex.org/W1527846216","https://openalex.org/W1908529059","https://openalex.org/W1919573053","https://openalex.org/W1920574243","https://openalex.org/W1975417448","https://openalex.org/W1995785668","https://openalex.org/W1999718282","https://openalex.org/W1999870633","https://openalex.org/W2006015474","https://openalex.org/W2018628396","https://openalex.org/W2028775910","https://openalex.org/W2029098371","https://openalex.org/W2029272045","https://openalex.org/W2031606564","https://openalex.org/W2038248574","https://openalex.org/W2045504523","https://openalex.org/W2049776068","https://openalex.org/W2055043387","https://openalex.org/W2059282068","https://openalex.org/W2060178110","https://openalex.org/W2061312063","https://openalex.org/W2065140836","https://openalex.org/W2084518266","https://openalex.org/W2085421027","https://openalex.org/W2090632804","https://openalex.org/W2106678197","https://openalex.org/W2110447200","https://openalex.org/W2113962028","https://openalex.org/W2119916602","https://openalex.org/W2121214853","https://openalex.org/W2121878323","https://openalex.org/W2127812211","https://openalex.org/W2132928157","https://openalex.org/W2140282079","https://openalex.org/W2155257264","https://openalex.org/W2155896486","https://openalex.org/W2157227311","https://openalex.org/W2169580261","https://openalex.org/W2266458160","https://openalex.org/W2280681614","https://openalex.org/W2281026738","https://openalex.org/W2313423684"],"related_works":["https://openalex.org/W2475350494","https://openalex.org/W2905993863","https://openalex.org/W2467139536","https://openalex.org/W2522611053","https://openalex.org/W2467512909","https://openalex.org/W625074148","https://openalex.org/W2594599809","https://openalex.org/W7119788509","https://openalex.org/W2045605395","https://openalex.org/W1908529059"],"abstract_inverted_index":{"The":[0],"molecular":[1],"pathways":[2],"controlling":[3],"gender":[4],"are":[5],"highly":[6],"variable":[7],"and":[8,37,60],"have":[9,35],"been":[10],"identified":[11],"in":[12,46],"only":[13],"a":[14,26,39,63],"few":[15],"nonmammalian":[16],"model":[17],"species.":[18],"In":[19],"many":[20],"insects,":[21],"maleness":[22],"is":[23,77],"conferred":[24],"by":[25],"Y":[27],"chromosome-linked":[28],"M":[29,44],"factor":[30,45],"of":[31,57,69,83,99],"unknown":[32],"nature.":[33],"We":[34],"isolated":[36],"characterized":[38],"gene,":[40],"Yob,":[41,52],"for":[42,97,105],"the":[43,47,55,70],"malaria":[48,106],"mosquito":[49],"Anopheles":[50,103],"gambiae":[51],"activated":[53],"at":[54],"beginning":[56],"zygotic":[58],"transcription":[59],"expressed":[61],"throughout":[62],"male's":[64],"life,":[65],"controls":[66],"male-specific":[67],"splicing":[68],"doublesex":[71],"gene.":[72],"Silencing":[73],"embryonic":[74,81],"Yob":[75,84],"expression":[76],"male-lethal,":[78],"whereas":[79],"ectopic":[80],"delivery":[82],"transcripts":[85],"yields":[86],"male-only":[87,101],"broods.":[88],"This":[89],"female-killing":[90],"property":[91],"may":[92],"be":[93],"an":[94],"invaluable":[95],"tool":[96],"creation":[98],"conditional":[100],"transgenic":[102],"strains":[104],"control":[107],"programs.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-07-22T00:00:00"}