{"id":"https://openalex.org/W2467956497","doi":null,"title":"[Prophylactic thyroidectomy in multiple endocrine neoplasia syndrome].","display_name":"[Prophylactic thyroidectomy in multiple endocrine neoplasia syndrome].","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2467956497","mag":"2467956497","pmid":"https://pubmed.ncbi.nlm.nih.gov/20405652"},"language":"es","primary_location":{"id":"pmid:20405652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20405652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056234074","display_name":"V Mariju\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"V Mariju\u00e1n","raw_affiliation_strings":["Hospital Materno-Infantil La Fe. Valencia. aliena1981@hotmail.com","Hospital Materno-Infantil La Fe. Valencia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Materno-Infantil La Fe. Valencia. aliena1981@hotmail.com","institution_ids":["https://openalex.org/I3019010403"]},{"raw_affiliation_string":"Hospital Materno-Infantil La Fe. Valencia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113205570","display_name":"Schurman Leon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Le\u00f3n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"F Moreno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Moreno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Carles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Carles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Roca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Roca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020297276","display_name":"Carlos Garc\u00eda-Sala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Garc\u00eda-Sala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112160186","display_name":"J L Ponce Marco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Ponce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2423,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.69806447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"22","issue":"4","first_page":"189","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-2a","display_name":"multiple endocrine neoplasia type 2A","score":0.9700000286102295},{"id":"https://openalex.org/keywords/prophylactic-thyroidectomy","display_name":"prophylactic thyroidectomy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ret-proto-oncogene-mutation","display_name":"RET proto-oncogene mutation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.875},{"id":"https://openalex.org/keywords/pheochromocytoma","display_name":"pheochromocytoma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/primary-hyperparathyroidism","display_name":"primary hyperparathyroidism","score":0.9139999747276306},{"id":"https://openalex.org/keywords/age-at-surgery","display_name":"age at surgery","score":0.6079999804496765},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.625},{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/urinary-metanephrines","display_name":"urinary metanephrines","score":0.906000018119812},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lymph-node-dissection","display_name":"lymph node dissection","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9164849519729614},{"id":"https://openalex.org/C2776783082","wikidata":"https://www.wikidata.org/wiki/Q412766","display_name":"Metanephrine","level":3,"score":0.753415584564209},{"id":"https://openalex.org/C2780103800","wikidata":"https://www.wikidata.org/wiki/Q1553018","display_name":"Multiple endocrine neoplasia","level":3,"score":0.7370272874832153},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.7231616973876953},{"id":"https://openalex.org/C2779512018","wikidata":"https://www.wikidata.org/wiki/Q536269","display_name":"Pheochromocytoma","level":2,"score":0.6178925633430481},{"id":"https://openalex.org/C2777074255","wikidata":"https://www.wikidata.org/wiki/Q1351681","display_name":"Thyroidectomy","level":3,"score":0.5954679846763611},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.5722982287406921},{"id":"https://openalex.org/C2776667971","wikidata":"https://www.wikidata.org/wiki/Q6807316","display_name":"Medullary carcinoma","level":4,"score":0.543192446231842},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.49274495244026184},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.4834462106227875},{"id":"https://openalex.org/C2775945674","wikidata":"https://www.wikidata.org/wiki/Q1344835","display_name":"Hyperparathyroidism","level":2,"score":0.4751149117946625},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4544515907764435},{"id":"https://openalex.org/C2776787253","wikidata":"https://www.wikidata.org/wiki/Q380064","display_name":"Endocrine surgery","level":3,"score":0.42862385511398315},{"id":"https://openalex.org/C2779644188","wikidata":"https://www.wikidata.org/wiki/Q415976","display_name":"RET proto-oncogene","level":5,"score":0.4142061173915863},{"id":"https://openalex.org/C2776512331","wikidata":"https://www.wikidata.org/wiki/Q604075","display_name":"Multiple endocrine neoplasia type 2","level":5,"score":0.41412997245788574},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34762901067733765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.330147385597229},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.1311284601688385},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.07508662343025208},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009377","descriptor_name":"Multiple Endocrine Neoplasia","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013965","descriptor_name":"Thyroidectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:20405652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20405652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2061326870","https://openalex.org/W1593077870","https://openalex.org/W2025526034","https://openalex.org/W2064498815","https://openalex.org/W2036601905","https://openalex.org/W2121769139","https://openalex.org/W1884965467","https://openalex.org/W2523338623","https://openalex.org/W2112727332","https://openalex.org/W2035766541"],"abstract_inverted_index":{"Multiple":[0],"endocrine":[1],"neoplasia":[2],"(MEN)":[3],"2a":[4,37],"consists":[5],"on":[6,102],"medullary":[7,166],"thyroid":[8,167],"carcinoma,":[9],"pheochromocytoma":[10],"and":[11,87,89,152,214,229,233],"hyperparathyroidism.":[12],"The":[13,97,119],"identification":[14],"of":[15,25,35,78,138,173,183,201,223],"the":[16,23,26,32,42,50,113,117,125,158,191,195,204],"RET":[17,122],"proto-oncogene":[18],"in":[19,38,46,106,112,135,143,157,170,181,190,225],"1993":[20],"has":[21],"changed":[22],"prognosis":[24],"disease.":[27],"We":[28,57],"have":[29],"retrospectively":[30],"studied":[31],"patients":[33,60,226],"diagnosed":[34,61],"MEN":[36,63],"our":[39],"centre":[40],"for":[41],"last":[43],"7":[44],"years":[45,72,81,231,252],"order":[47],"to":[48,54,70,250],"establish":[49],"most":[51,120],"adequate":[52],"age":[53,75],"undergo":[55],"surgery.":[56,96,162],"present":[58],"ten":[59],"with":[62],"2a,":[64],"whose":[65],"ages":[66],"ranged":[67],"from":[68,203,248],"1.5":[69],"11":[71],"old.":[73,253],"Mean":[74],"at":[76,245],"time":[77],"operation:":[79],"6,4":[80],"An":[82],"ultrasound":[83],"study,":[84],"calcitonin":[85,176],"determinations":[86],"cathecholamines":[88,213],"urinary":[90,215],"metanephrine":[91,216],"levels":[92],"were":[93,165,179,188],"obtained":[94],"before":[95],"surgical":[98],"treatment":[99],"is":[100,124],"based":[101],"total":[103,104],"thyroidectomy,":[105],"selected":[107],"cases":[108,222],"lymph":[109,192],"node":[110],"resection":[111],"central":[114],"zone":[115],"lf":[116],"neck.":[118],"frequent":[121],"mutation":[123],"one":[126,182],"affecting":[127],"codon":[128,144],"634":[129],"(exon":[130],"10),":[131],"which":[132],"was":[133],"found":[134,189],"children.":[136],"Both":[137],"them":[139],"had":[140],"an":[141],"alteration":[142],"611":[145],"(exon11).":[146],"No":[147,185],"complications":[148],"appeared":[149],"after":[150,161],"surgery":[151],"hospital":[153],"discharge":[154],"took":[155],"place":[156],"2nd-4th":[159],"day":[160],"Pathological":[163],"findings":[164],"microcarcinoma":[168],"(MTMC)":[169],"3":[171,221,228,249],"out":[172,200],"10":[174,202],"patients,":[175,206],"preoperative":[177],"tests":[178],"high":[180],"them.":[184],"tumoral":[186],"cells":[187],"nodes.":[193],"During":[194],"follow":[196],"up":[197],"period,":[198],"9":[199],"operated":[205],"maintained":[207],"normal":[208],"calcitonin,":[209],"CEA,":[210],"PTH,":[211],"calcium,":[212],"levels.":[217],"Since":[218],"there":[219],"are":[220,237],"MTC":[224],"between":[227],"6":[230],"old,":[232],"diagnostic":[234],"test":[235],"data":[236],"not":[238],"conclusive,":[239],"we":[240],"thoroughly":[241],"recommend":[242],"prophyilactic":[243],"thyroidectomy":[244],"early":[246],"ages,":[247],"4":[251]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}