{"id":"https://openalex.org/W2467951067","doi":"https://doi.org/10.1002/adfm.201601207","title":"Selective Photothermal Tumor Therapy Using Nanodiamond\u2010Based Nanoclusters with Folic Acid","display_name":"Selective Photothermal Tumor Therapy Using Nanodiamond\u2010Based Nanoclusters with Folic Acid","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2467951067","doi":"https://doi.org/10.1002/adfm.201601207","mag":"2467951067"},"language":"en","primary_location":{"id":"doi:10.1002/adfm.201601207","doi":"https://doi.org/10.1002/adfm.201601207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adfm.201601207","pdf_url":null,"source":{"id":"https://openalex.org/S135204980","display_name":"Advanced Functional Materials","issn_l":"1616-301X","issn":["1616-301X","1616-3028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-3","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Functional Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078999967","display_name":"Taekyung Ryu","orcid":"https://orcid.org/0000-0001-5242-9923","observed_orcids":["https://orcid.org/0000-0001-5242-9923"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae\u2010Kyung Ryu","raw_affiliation_strings":["Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-743 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-743 Republic of Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110861563","display_name":"Seung Woon Baek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung Woon Baek","raw_affiliation_strings":["Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-743 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-743 Republic of Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026947683","display_name":"Rae Hyung Kang","orcid":"https://orcid.org/0000-0001-9380-6553","observed_orcids":["https://orcid.org/0000-0001-9380-6553"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Rae Hyung Kang","raw_affiliation_strings":["Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-743 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-743 Republic of Korea","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103244076","display_name":"Sung\u2010Wook Choi","orcid":"https://orcid.org/0000-0002-5075-8798","observed_orcids":["https://orcid.org/0000-0002-5075-8798"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sung\u2010Wook Choi","raw_affiliation_strings":["Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-743 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-743 Republic of Korea","institution_ids":["https://openalex.org/I87111246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103244076"],"corresponding_institution_ids":["https://openalex.org/I87111246"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":3.2325,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.92390779,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"26","issue":"35","first_page":"6428","last_page":"6436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11342","display_name":"Carbon and Quantum Dots Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/folic-acid-conjugation","display_name":"folic acid conjugation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.8460000157356262},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.5839999914169312},{"id":"https://openalex.org/keywords/near-infrared-laser","display_name":"near-infrared laser","score":0.8700000047683716},{"id":"https://openalex.org/keywords/kb-cells","display_name":"KB cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6320000290870667},{"id":"https://openalex.org/keywords/tumor-shrinkage","display_name":"tumor shrinkage","score":0.6000000238418579},{"id":"https://openalex.org/keywords/surface-functionalization","display_name":"surface functionalization","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2778402822","wikidata":"https://www.wikidata.org/wiki/Q22302226","display_name":"Nanoclusters","level":2,"score":0.9761444330215454},{"id":"https://openalex.org/C2780306303","wikidata":"https://www.wikidata.org/wiki/Q24784504","display_name":"Folate receptor","level":4,"score":0.7653920650482178},{"id":"https://openalex.org/C182606246","wikidata":"https://www.wikidata.org/wiki/Q7187926","display_name":"Photothermal therapy","level":2,"score":0.7488908767700195},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6711538434028625},{"id":"https://openalex.org/C2777715892","wikidata":"https://www.wikidata.org/wiki/Q16870989","display_name":"Nanodiamond","level":3,"score":0.6009734869003296},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5240083932876587},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.48175597190856934},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3914109468460083},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3548947274684906},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.32844191789627075},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32811933755874634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1696566939353943},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11633899807929993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11503022909164429},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09972727298736572},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.07918033003807068},{"id":"https://openalex.org/C2776921476","wikidata":"https://www.wikidata.org/wiki/Q5283","display_name":"Diamond","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/adfm.201601207","doi":"https://doi.org/10.1002/adfm.201601207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adfm.201601207","pdf_url":null,"source":{"id":"https://openalex.org/S135204980","display_name":"Advanced Functional Materials","issn_l":"1616-301X","issn":["1616-301X","1616-3028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-3","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Functional Materials","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3355884764","display_name":null,"funder_award_id":"NRF-2015R1A4A1042350","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"}],"funders":[{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1560482245","https://openalex.org/W1903778810","https://openalex.org/W1954228318","https://openalex.org/W1969437382","https://openalex.org/W1972154409","https://openalex.org/W1973359919","https://openalex.org/W1974892535","https://openalex.org/W1986218064","https://openalex.org/W1986858561","https://openalex.org/W2000518811","https://openalex.org/W2000725843","https://openalex.org/W2011529228","https://openalex.org/W2013476969","https://openalex.org/W2027137358","https://openalex.org/W2028085568","https://openalex.org/W2028119065","https://openalex.org/W2036181729","https://openalex.org/W2037774202","https://openalex.org/W2044125214","https://openalex.org/W2049405595","https://openalex.org/W2053519377","https://openalex.org/W2057427618","https://openalex.org/W2073765250","https://openalex.org/W2075832148","https://openalex.org/W2078057254","https://openalex.org/W2079566206","https://openalex.org/W2080558701","https://openalex.org/W2082731263","https://openalex.org/W2083241496","https://openalex.org/W2124156519","https://openalex.org/W2129519417","https://openalex.org/W2135219744","https://openalex.org/W2161900304","https://openalex.org/W2166395219","https://openalex.org/W2166963893","https://openalex.org/W2170857216","https://openalex.org/W2313232242","https://openalex.org/W2321892255","https://openalex.org/W4234241831"],"related_works":["https://openalex.org/W2523111130","https://openalex.org/W3083971141","https://openalex.org/W2968028831","https://openalex.org/W2082355295","https://openalex.org/W1834247112","https://openalex.org/W3199763334","https://openalex.org/W2047620771","https://openalex.org/W3159239025","https://openalex.org/W2080558701","https://openalex.org/W2791164424"],"abstract_inverted_index":{"This":[0],"paper":[1],"describes":[2],"the":[3],"fabrication":[4],"and":[5,29,93],"evaluation":[6],"of":[7,38,137],"folic":[8],"acid":[9],"(FA)\u2010conjugated":[10],"nanodiamond":[11],"(ND)":[12],"nanoclusters":[13,20,58,91,116,139],"for":[14,54,78],"selective":[15],"photothermal":[16],"tumor":[17,79,143,149],"therapy.":[18],"ND":[19,41,157],"with":[21,31,114],"surface":[22],"carboxyl":[23],"groups":[24],"are":[25,59,117],"aminated":[26],"using":[27],"ethylenediamine":[28],"conjugated":[30],"FA":[32],"via":[33],"carbodiimide":[34],"chemistry.":[35],"The":[36],"temperature":[37],"an":[39,131],"aqueous":[40],"dispersion":[42],"(10":[43],"\u03bcg":[44],"mL\u22121)":[45],"is":[46,140],"increased":[47],"to":[48,70,156],"54":[49],"\u00b0C":[50],"upon":[51,98],"laser":[52,101,128,152],"exposure":[53,153],"5":[55],"min.":[56],"FA\u2010ND":[57,90,115,138],"preferentially":[60],"taken":[61],"up":[62],"by":[63,126],"KB":[64,96,111],"cells":[65,80,97,112],"(folate":[66,72],"receptor":[67,73],"positive)":[68],"compared":[69,155],"WI\u201038":[71],"negative)":[74],"cells,":[75],"suggesting":[76],"specificity":[77],"that":[81,89,109],"overexpress":[82],"folate":[83],"receptors.":[84],"Cell":[85],"viability":[86],"tests":[87],"reveal":[88],"effectively":[92],"selectively":[94],"ablate":[95],"near\u2010infrared":[99],"(NIR)":[100],"exposure.":[102,129],"In":[103,130],"addition,":[104],"fluorescence":[105],"microscopy":[106],"images":[107],"confirm":[108],"only":[110],"treated":[113],"ablated":[118],"in":[119,124,146],"a":[120,134],"spot":[121],"(200":[122],"\u03bcm":[123],"diameter)":[125],"NIR":[127],"animal":[132],"model,":[133],"large":[135],"amount":[136],"accumulated":[141],"into":[142],"tissue,":[144],"resulting":[145],"dramatically":[147],"reduced":[148],"volume":[150],"post\u2010NIR":[151],"as":[154],"nanoclusters.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-07-22T00:00:00"}