{"id":"https://openalex.org/W2467887695","doi":"https://doi.org/10.1371/journal.ppat.1005748","title":"Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFN\u03b3-Like Response","display_name":"Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFN\u03b3-Like Response","publication_year":2016,"publication_date":"2016-07-07","ids":{"openalex":"https://openalex.org/W2467887695","doi":"https://doi.org/10.1371/journal.ppat.1005748","mag":"2467887695","pmid":"https://pubmed.ncbi.nlm.nih.gov/27387064","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4936752"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1005748","doi":"https://doi.org/10.1371/journal.ppat.1005748","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005748","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005748&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005748&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009735504","display_name":"Thomas Harwardt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Harwardt","raw_affiliation_strings":["Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085436465","display_name":"Simone Lukas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simone Lukas","raw_affiliation_strings":["Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083807095","display_name":"Marion Zenger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marion Zenger","raw_affiliation_strings":["Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087849009","display_name":"Tobias Reitberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Reitberger","raw_affiliation_strings":["Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073476519","display_name":"Daniela Danzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniela Danzer","raw_affiliation_strings":["Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064568448","display_name":"\u00dcbner Theresa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Theresa \u00dcbner","raw_affiliation_strings":["Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018448161","display_name":"Diane C. Munday","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Diane C. Munday","raw_affiliation_strings":["Biomedical Sciences Research Complex, University of St Andrews, St Andrews, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Research Complex, University of St Andrews, St Andrews, United Kingdom","institution_ids":["https://openalex.org/I16835326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082282790","display_name":"Michael M. Nevels","orcid":"https://orcid.org/0000-0002-7115-407X","observed_orcids":["https://orcid.org/0000-0002-7115-407X"]},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]},{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Michael Nevels","raw_affiliation_strings":["Biomedical Sciences Research Complex, University of St Andrews, St Andrews, United Kingdom","Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7115-407X","affiliations":[{"raw_affiliation_string":"Biomedical Sciences Research Complex, University of St Andrews, St Andrews, United Kingdom","institution_ids":["https://openalex.org/I16835326"]},{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053166356","display_name":"Christina Paulus","orcid":"https://orcid.org/0000-0002-4123-5629","observed_orcids":["https://orcid.org/0000-0002-4123-5629"]},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]},{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Christina Paulus","raw_affiliation_strings":["Biomedical Sciences Research Complex, University of St Andrews, St Andrews, United Kingdom","Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Research Complex, University of St Andrews, St Andrews, United Kingdom","institution_ids":["https://openalex.org/I16835326"]},{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053166356","https://openalex.org/A5082282790"],"corresponding_institution_ids":["https://openalex.org/I16835326","https://openalex.org/I4210140742","https://openalex.org/I60668342"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":2409,"currency":"EUR","value_usd":2598},"fwci":4.8716,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.95219856,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"12","issue":"7","first_page":"e1005748","last_page":"e1005748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.5029000043869019,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.5029000043869019,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8849999904632568},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/il-6-signaling","display_name":"IL-6 signaling","score":0.7730000019073486},{"id":"https://openalex.org/keywords/il-6-receptor","display_name":"IL-6 receptor","score":0.7889999747276306},{"id":"https://openalex.org/keywords/jak1","display_name":"JAK1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7749999761581421},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.49399998784065247},{"id":"https://openalex.org/keywords/viral-replication-restriction","display_name":"viral replication restriction","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.5400000214576721},{"id":"https://openalex.org/keywords/stat3-binding-sites","display_name":"STAT3 binding sites","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.7425247430801392},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.7258148789405823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6601738929748535},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.5721656084060669},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.515207827091217},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4925406873226166},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.46568384766578674},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4546507000923157},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4058187007904053},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3710026741027832},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3142848014831543},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3074270486831665},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21209940314292908},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11601820588111877}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1005748","doi":"https://doi.org/10.1371/journal.ppat.1005748","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005748","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005748&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4936752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4936752","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:27387064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27387064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:34494","doi":null,"is_oa":false,"landing_page_url":"http://orcid.org/0000-0002-7115-407X>","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:0042f25a39564c1e908b29862357b1e0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0042f25a39564c1e908b29862357b1e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 12, Iss 7, p e1005748 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/3474197","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Human_Cytomegalovirus_Immediate-Early_1_Protein_Rewires_Upstream_STAT3_to_Downstream_STAT1_Signaling_Switching_an_IL6-Type_to_an_IFN_-Like_Response/3474197","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:research-repository.st-andrews.ac.uk:10023/9124","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10023/9124","pdf_url":null,"source":{"id":"https://openalex.org/S4306400230","display_name":"St Andrews Research Repository (St Andrews Research Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16835326","host_organization_name":"University of St Andrews","host_organization_lineage":["https://openalex.org/I16835326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"doi:10.5283/epub.34494","doi":"https://doi.org/10.5283/epub.34494","is_oa":true,"landing_page_url":"https://doi.org/10.5283/epub.34494","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1005748","doi":"https://doi.org/10.1371/journal.ppat.1005748","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005748","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005748&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.61080002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4025430629","display_name":null,"funder_award_id":"PA 815/2-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2467887695.pdf","grobid_xml":"https://content.openalex.org/works/W2467887695.grobid-xml"},"referenced_works_count":181,"referenced_works":["https://openalex.org/W125742586","https://openalex.org/W1481036493","https://openalex.org/W1481183414","https://openalex.org/W1486822318","https://openalex.org/W1511170523","https://openalex.org/W1538370504","https://openalex.org/W1562695264","https://openalex.org/W1601185603","https://openalex.org/W1601667381","https://openalex.org/W1623819487","https://openalex.org/W1743711678","https://openalex.org/W1779691448","https://openalex.org/W1795403715","https://openalex.org/W1809966404","https://openalex.org/W1810441673","https://openalex.org/W1810927385","https://openalex.org/W1826236781","https://openalex.org/W1883822573","https://openalex.org/W1898584802","https://openalex.org/W1957027480","https://openalex.org/W1963112395","https://openalex.org/W1964000992","https://openalex.org/W1965372133","https://openalex.org/W1968537310","https://openalex.org/W1969633526","https://openalex.org/W1969704076","https://openalex.org/W1971510009","https://openalex.org/W1977896329","https://openalex.org/W1981525236","https://openalex.org/W1981558989","https://openalex.org/W1981892114","https://openalex.org/W1982161030","https://openalex.org/W1982448036","https://openalex.org/W1983262257","https://openalex.org/W1983453744","https://openalex.org/W1983800149","https://openalex.org/W1983989619","https://openalex.org/W1984339902","https://openalex.org/W1984733998","https://openalex.org/W1986669563","https://openalex.org/W1987395342","https://openalex.org/W1987594887","https://openalex.org/W1991308016","https://openalex.org/W1993757260","https://openalex.org/W1994257969","https://openalex.org/W1994882633","https://openalex.org/W2001743184","https://openalex.org/W2004057537","https://openalex.org/W2004770182","https://openalex.org/W2007127557","https://openalex.org/W2008210462","https://openalex.org/W2009177754","https://openalex.org/W2010406049","https://openalex.org/W2010592156","https://openalex.org/W2012917093","https://openalex.org/W2013344201","https://openalex.org/W2015636800","https://openalex.org/W2015666319","https://openalex.org/W2016810616","https://openalex.org/W2019050142","https://openalex.org/W2019590755","https://openalex.org/W2021340905","https://openalex.org/W2022819740","https://openalex.org/W2023930134","https://openalex.org/W2024377138","https://openalex.org/W2026123089","https://openalex.org/W2028067246","https://openalex.org/W2028382828","https://openalex.org/W2028544780","https://openalex.org/W2030246164","https://openalex.org/W2030573627","https://openalex.org/W2030624761","https://openalex.org/W2032471037","https://openalex.org/W2033136975","https://openalex.org/W2033225657","https://openalex.org/W2033448230","https://openalex.org/W2035914733","https://openalex.org/W2036156710","https://openalex.org/W2036263889","https://openalex.org/W2036343954","https://openalex.org/W2037316198","https://openalex.org/W2038107886","https://openalex.org/W2038976543","https://openalex.org/W2043025538","https://openalex.org/W2044728514","https://openalex.org/W2045310262","https://openalex.org/W2049596485","https://openalex.org/W2052908887","https://openalex.org/W2054712629","https://openalex.org/W2054989124","https://openalex.org/W2059195164","https://openalex.org/W2059903333","https://openalex.org/W2061070237","https://openalex.org/W2061600924","https://openalex.org/W2065447003","https://openalex.org/W2067476313","https://openalex.org/W2071886635","https://openalex.org/W2073002157","https://openalex.org/W2073558615","https://openalex.org/W2073974060","https://openalex.org/W2074012862","https://openalex.org/W2075325752","https://openalex.org/W2076372272","https://openalex.org/W2077619366","https://openalex.org/W2077860499","https://openalex.org/W2079297432","https://openalex.org/W2079596789","https://openalex.org/W2079701917","https://openalex.org/W2090513105","https://openalex.org/W2091478221","https://openalex.org/W2091582623","https://openalex.org/W2092916151","https://openalex.org/W2094750435","https://openalex.org/W2094854714","https://openalex.org/W2096372976","https://openalex.org/W2097567176","https://openalex.org/W2097904070","https://openalex.org/W2098492050","https://openalex.org/W2099171741","https://openalex.org/W2099287558","https://openalex.org/W2099303824","https://openalex.org/W2099578825","https://openalex.org/W2100837269","https://openalex.org/W2104719053","https://openalex.org/W2104840383","https://openalex.org/W2106219094","https://openalex.org/W2106588382","https://openalex.org/W2107713440","https://openalex.org/W2109032735","https://openalex.org/W2110670582","https://openalex.org/W2111260652","https://openalex.org/W2112333537","https://openalex.org/W2112949761","https://openalex.org/W2113253427","https://openalex.org/W2113605746","https://openalex.org/W2115653742","https://openalex.org/W2116609639","https://openalex.org/W2117271390","https://openalex.org/W2118195499","https://openalex.org/W2119609500","https://openalex.org/W2123375391","https://openalex.org/W2124238701","https://openalex.org/W2124342322","https://openalex.org/W2126155653","https://openalex.org/W2127707170","https://openalex.org/W2128159409","https://openalex.org/W2128719261","https://openalex.org/W2132173287","https://openalex.org/W2133132321","https://openalex.org/W2133947803","https://openalex.org/W2135401517","https://openalex.org/W2138149983","https://openalex.org/W2140013858","https://openalex.org/W2140018049","https://openalex.org/W2140594956","https://openalex.org/W2142189521","https://openalex.org/W2144773116","https://openalex.org/W2145237733","https://openalex.org/W2147491616","https://openalex.org/W2149615892","https://openalex.org/W2153496521","https://openalex.org/W2153620197","https://openalex.org/W2153805460","https://openalex.org/W2154307789","https://openalex.org/W2156322878","https://openalex.org/W2157071824","https://openalex.org/W2157408286","https://openalex.org/W2158046192","https://openalex.org/W2159812354","https://openalex.org/W2160320495","https://openalex.org/W2161086529","https://openalex.org/W2164236637","https://openalex.org/W2168421200","https://openalex.org/W2168635191","https://openalex.org/W2187131173","https://openalex.org/W2258028385","https://openalex.org/W2273547594","https://openalex.org/W2277932334","https://openalex.org/W4247413509","https://openalex.org/W4285719527","https://openalex.org/W4313377034"],"related_works":["https://openalex.org/W2140018049","https://openalex.org/W2024377138","https://openalex.org/W7095528385","https://openalex.org/W2038107886","https://openalex.org/W2043025538","https://openalex.org/W7097754670","https://openalex.org/W1968537310","https://openalex.org/W2102302996","https://openalex.org/W6887841897","https://openalex.org/W1882708317"],"abstract_inverted_index":{"The":[0,75],"human":[1],"cytomegalovirus":[2],"(hCMV)":[3],"major":[4],"immediate-early":[5],"1":[6],"protein":[7,159,269],"(IE1)":[8],"is":[9,27,34,60,172,202],"best":[10],"known":[11],"for":[12,107,162],"activating":[13],"transcription":[14],"to":[15,44,91,117,140,170,206,210,217,243,248,271],"facilitate":[16],"viral":[17,196,244,287],"replication.":[18,197,288],"Here":[19],"we":[20],"present":[21,174],"transcriptome":[22],"data":[23],"indicating":[24],"that":[25,200,253,266],"IE1":[26,46,149,201,237],"as":[28,32,103],"significant":[29],"a":[30,104,157,179,268,273],"repressor":[31,232],"it":[33],"an":[35,186,282],"activator":[36,234,275],"of":[37,50,67,97,110,122,144,236,276],"host":[38],"gene":[39],"expression.":[40],"Human":[41],"cells":[42,155,176],"induced":[43,72],"express":[45],"exhibit":[47],"global":[48],"repression":[49,59,77],"IL6-":[51],"and":[52,65,78,99,190,204,224,233,238],"oncostatin":[53],"M-responsive":[54],"STAT3":[55,111,145,163],"target":[56,69],"genes.":[57,227],"This":[58],"followed":[61],"by":[62,73],"STAT1":[63,68,142],"phosphorylation":[64],"activation":[66,80,146],"genes":[70],"normally":[71],"IFN\u03b3.":[74],"observed":[76],"subsequent":[79],"are":[81],"both":[82],"mediated":[83],"through":[84,255],"the":[85,94,113,123,128,256,277],"same":[86],"region":[87,101],"(amino":[88],"acids":[89],"410":[90],"445)":[92],"in":[93,147,154,175,194,221,246,259,285],"C-terminal":[95],"domain":[96],"IE1,":[98,267],"this":[100,133,191],"serves":[102],"binding":[105],"site":[106],"STAT3.":[108],"Depletion":[109],"phenocopies":[112],"STAT1-dependent":[114],"IFN\u03b3-like":[115,212],"response":[116,169,192,247],"IE1.":[118],"In":[119],"contrast,":[120],"depletion":[121],"IL6":[124,138,171],"receptor":[125],"(IL6ST)":[126],"or":[127,181,250],"STAT":[129],"kinase":[130],"JAK1":[131],"prevents":[132],"response.":[134],"Accordingly,":[135],"treatment":[136],"with":[137,178],"leads":[139],"prolonged":[141],"instead":[143],"wild-type":[148,180],"expressing":[150,156],"cells,":[151],"but":[152,184],"not":[153,185],"mutant":[158,188],"(IE1dl410-420)":[160],"deficient":[161],"binding.":[164],"A":[165],"very":[166],"similar":[167],"STAT1-directed":[168],"also":[173,264],"infected":[177],"revertant":[182],"hCMV,":[183],"IE1dl410-420":[187],"virus,":[189],"results":[193,263],"restricted":[195],"We":[198],"conclude":[199],"sufficient":[203],"necessary":[205],"rewire":[207],"upstream":[208],"IL6-type":[209],"downstream":[211],"signaling,":[213],"two":[214],"pathways":[215],"linked":[216],"opposing":[218],"actions,":[219],"resulting":[220],"repressed":[222],"STAT3-":[223],"activated":[225],"STAT1-responsive":[226],"These":[228],"findings":[229],"relate":[230],"transcriptional":[231],"functions":[235],"suggest":[239],"unexpected":[240],"outcomes":[241],"relevant":[242],"pathogenesis":[245],"cytokines":[249],"growth":[251],"factors":[252],"signal":[254],"IL6ST-JAK1-STAT3":[257],"axis":[258],"hCMV-infected":[260],"cells.":[261],"Our":[262],"reveal":[265],"considered":[270],"be":[272],"key":[274],"hCMV":[278],"productive":[279],"cycle,":[280],"has":[281],"unanticipated":[283],"role":[284],"tempering":[286]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-07-22T00:00:00"}