{"id":"https://openalex.org/W2467850446","doi":null,"title":"[Effect of metoprolol on water drinking activity in Wistar Kyoto rats].","display_name":"[Effect of metoprolol on water drinking activity in Wistar Kyoto rats].","publication_year":1984,"publication_date":"1984-07-01","ids":{"openalex":"https://openalex.org/W2467850446","mag":"2467850446","pmid":"https://pubmed.ncbi.nlm.nih.gov/6489919"},"language":"ja","primary_location":{"id":"pmid:6489919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6489919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"[Hokkaido igaku zasshi] The Hokkaido journal of medical science","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070407720","display_name":"Masabumi Minami","orcid":"https://orcid.org/0000-0002-0144-0679","observed_orcids":["https://orcid.org/0000-0002-0144-0679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Minami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058419126","display_name":"H Togashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Togashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108618526","display_name":"Machiko SANO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Sano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"I Saito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Saito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053628284","display_name":"Ken Morii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Morii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Nomura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Nomura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077245665","display_name":"M Kurosawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kurosawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007404836","display_name":"M Yoshioka","orcid":"https://orcid.org/0000-0003-3390-4420","observed_orcids":["https://orcid.org/0000-0003-3390-4420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Yoshioka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044298809","display_name":"Hiroshi Saito","orcid":"https://orcid.org/0000-0002-3338-478X","observed_orcids":["https://orcid.org/0000-0002-3338-478X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Saito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42524701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"59","issue":"4","first_page":"471","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.13009999692440033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metoprolol","display_name":"metoprolol","score":1.0},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.7419999837875366},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.8619999885559082},{"id":"https://openalex.org/keywords/beta-1-selectivity","display_name":"beta-1 selectivity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/bradycardia","display_name":"bradycardia","score":0.7639999985694885},{"id":"https://openalex.org/keywords/urinary-catecholamine-excretion","display_name":"urinary catecholamine excretion","score":0.8510000109672546},{"id":"https://openalex.org/keywords/aldosterone-excretion","display_name":"aldosterone excretion","score":0.8450000286102295},{"id":"https://openalex.org/keywords/wistar-kyoto-rats","display_name":"Wistar-Kyoto rats","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2781280847","wikidata":"https://www.wikidata.org/wiki/Q409468","display_name":"Metoprolol","level":2,"score":0.985123336315155},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.8367148637771606},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6636946797370911},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.5700945854187012},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5610314011573792},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.553882360458374},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.5400233268737793},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4786318838596344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42635005712509155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38497671484947205}],"mesh":[{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004326","descriptor_name":"Drinking","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008790","descriptor_name":"Metoprolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6489919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6489919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"[Hokkaido igaku zasshi] The Hokkaido journal of medical science","raw_type":"English Abstract"},{"id":"mag:2467850446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6489919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1996094849","https://openalex.org/W3034057270","https://openalex.org/W2025187336","https://openalex.org/W2023692842","https://openalex.org/W2035953551","https://openalex.org/W2334278190","https://openalex.org/W2010360597","https://openalex.org/W4318444695","https://openalex.org/W2304224409","https://openalex.org/W2023550534"],"abstract_inverted_index":{"The":[0],"study":[1],"was":[2],"undertaken":[3],"to":[4,130],"elucidate":[5],"the":[6,40,58,63,81,87,133,167],"effect":[7],"of":[8,30,44,104,117,173,177],"beta":[9,97,168],"1":[10,98,169],"adrenoceptor":[11],"blocking":[12,171],"agent,":[13],"metoprolol,":[14],"on":[15],"water":[16,118,137,184],"drinking":[17,119,138,185],"activity":[18,120,139],"in":[19,39,52,55,72,80,126,128,132,183,187],"Wistar":[20],"Kyoto":[21],"rats":[22,61,67],"(WKY).":[23],"Both":[24],"7":[25],"day":[26],"(10mg/kg/day)":[27],"oral":[28],"administration":[29],"metoprolol":[31,47,82,95,112,134,159,178],"and":[32,145,151],"propranolol":[33,59],"did":[34,108,121,155],"not":[35,109,122,156],"produce":[36],"any":[37,69,124,181],"changes":[38,71,125],"systolic":[41],"blood":[42],"pressure":[43],"WKY.":[45,56,188],"However,":[46],"produced":[48],"a":[49,174],"significant":[50,70],"decrease":[51],"heart":[53,73],"rate":[54],"Neither":[57],"treated":[60],"nor":[62],"control":[64],"(non-drug":[65],"group)":[66],"showed":[68],"rate.":[74],"Heart":[75],"rates":[76,154],"were":[77],"significantly":[78],"changed":[79],"group":[83],"as":[84],"compared":[85],"with":[86,142],"other":[88],"two":[89],"groups.":[90],"This":[91],"finding":[92],"reconfirms":[93],"that":[94,164,179],"has":[96],"selectivity.":[99],"Drinking":[100],"activity,":[101],"an":[102],"indicator":[103],"central":[105],"nervous":[106],"function,":[107],"change":[110,157,182],"after":[111,158],"administration.":[113,160],"Power":[114],"spectral":[115],"analysis":[116],"reveal":[123],"rhythm":[127],"respect":[129],"periodicity":[131],"group.":[135],"Although":[136],"is":[140,166],"synchronized":[141],"urinary":[143,149],"catecholamine":[144,150],"aldosterone":[146,152],"excretion":[147,153],"rates,":[148],"These":[161],"findings":[162],"suggest":[163],"it":[165],"adrenergic":[170],"action":[172],"bradycardia-producing":[175],"dose":[176],"prevented":[180],"behavior":[186]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-07-22T00:00:00"}