{"id":"https://openalex.org/W246784873","doi":null,"title":"From Cellular Components to Living Cells (and Back): Evolution of Function in Biological Networks","display_name":"From Cellular Components to Living Cells (and Back): Evolution of Function in Biological Networks","publication_year":2011,"publication_date":"2011-06-15","ids":{"openalex":"https://openalex.org/W246784873","mag":"246784873"},"language":"en","primary_location":{"id":"pmh:oai:www.db-thueringen.de:dbt_mods_00018529","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:gbv:27-20110615-103318-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400120","display_name":"Common Library Network (Der Gemeinsame Bibliotheksverbund)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210149878","host_organization_name":"Verbundzentrale des GBV","host_organization_lineage":["https://openalex.org/I4210149878"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://nbn-resolving.org/urn:nbn:de:gbv:27-20110615-103318-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046892467","display_name":"Thorsten Lenser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lenser, Thorsten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046892467"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy of Biology and Scientific Explanation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/network-structure-and-function","display_name":"network structure and function","score":0.6869999766349792},{"id":"https://openalex.org/keywords/artificial-evolution","display_name":"artificial evolution","score":0.7120000123977661},{"id":"https://openalex.org/keywords/evolutionary-algorithms","display_name":"evolutionary algorithms","score":0.7710000276565552},{"id":"https://openalex.org/keywords/reaction-kinetics","display_name":"reaction kinetics","score":0.39399999380111694},{"id":"https://openalex.org/keywords/pml-nuclear-bodies","display_name":"PML nuclear bodies","score":0.8510000109672546},{"id":"https://openalex.org/keywords/frap-assay","display_name":"FRAP","score":0.6710000038146973},{"id":"https://openalex.org/keywords/model-inference","display_name":"model inference","score":0.8700000047683716},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.6769999861717224},{"id":"https://openalex.org/keywords/stochastic-gene-expression","display_name":"stochastic gene expression","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.6819999814033508},{"id":"https://openalex.org/keywords/monte-carlo-simulation","display_name":"Monte Carlo simulation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/master-equation","display_name":"master equation","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5641688108444214},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5137239694595337},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5015692710876465},{"id":"https://openalex.org/C31170391","wikidata":"https://www.wikidata.org/wiki/Q188619","display_name":"Hierarchy","level":2,"score":0.46689045429229736},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.43432071805000305},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.43151354789733887},{"id":"https://openalex.org/C19273510","wikidata":"https://www.wikidata.org/wiki/Q263847","display_name":"Artificial life","level":2,"score":0.4278469979763031},{"id":"https://openalex.org/C124304363","wikidata":"https://www.wikidata.org/wiki/Q673661","display_name":"Abstraction","level":2,"score":0.4246000051498413},{"id":"https://openalex.org/C2776184637","wikidata":"https://www.wikidata.org/wiki/Q6506039","display_name":"Living systems","level":2,"score":0.42172694206237793},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4107973873615265},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3882395029067993},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3256690502166748},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25563737750053406},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.23388847708702087},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.18228474259376526},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:www.db-thueringen.de:dbt_mods_00018529","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:gbv:27-20110615-103318-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400120","display_name":"Common Library Network (Der Gemeinsame Bibliotheksverbund)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210149878","host_organization_name":"Verbundzentrale des GBV","host_organization_lineage":["https://openalex.org/I4210149878"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dissertation"}],"best_oa_location":{"id":"pmh:oai:www.db-thueringen.de:dbt_mods_00018529","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:gbv:27-20110615-103318-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400120","display_name":"Common Library Network (Der Gemeinsame Bibliotheksverbund)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210149878","host_organization_name":"Verbundzentrale des GBV","host_organization_lineage":["https://openalex.org/I4210149878"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":139,"referenced_works":["https://openalex.org/W26198858","https://openalex.org/W95584486","https://openalex.org/W162935903","https://openalex.org/W241749521","https://openalex.org/W278377992","https://openalex.org/W1480936263","https://openalex.org/W1482637285","https://openalex.org/W1484198052","https://openalex.org/W1512383952","https://openalex.org/W1532337293","https://openalex.org/W1532826969","https://openalex.org/W1553544241","https://openalex.org/W1556421650","https://openalex.org/W1573534773","https://openalex.org/W1576818901","https://openalex.org/W1587411234","https://openalex.org/W1587445693","https://openalex.org/W1589720045","https://openalex.org/W1603664789","https://openalex.org/W1603696475","https://openalex.org/W1603793127","https://openalex.org/W1605438009","https://openalex.org/W1635552303","https://openalex.org/W1637936532","https://openalex.org/W1644749979","https://openalex.org/W1763200058","https://openalex.org/W1835387731","https://openalex.org/W1886596768","https://openalex.org/W1957493983","https://openalex.org/W1963522244","https://openalex.org/W1970768185","https://openalex.org/W1971266246","https://openalex.org/W1973081915","https://openalex.org/W1973441240","https://openalex.org/W1976169445","https://openalex.org/W1976202310","https://openalex.org/W1977940795","https://openalex.org/W1978122953","https://openalex.org/W1978319180","https://openalex.org/W1978486653","https://openalex.org/W1982865896","https://openalex.org/W1986242149","https://openalex.org/W1986482900","https://openalex.org/W1987815409","https://openalex.org/W1989921625","https://openalex.org/W1990600049","https://openalex.org/W1990953761","https://openalex.org/W1992003277","https://openalex.org/W1996195324","https://openalex.org/W1996529795","https://openalex.org/W1998399559","https://openalex.org/W1998475589","https://openalex.org/W1999611553","https://openalex.org/W2000867210","https://openalex.org/W2004875674","https://openalex.org/W2007795630","https://openalex.org/W2009741547","https://openalex.org/W2020561965","https://openalex.org/W2023033376","https://openalex.org/W2023670646","https://openalex.org/W2026754797","https://openalex.org/W2027688256","https://openalex.org/W2032700586","https://openalex.org/W2032811716","https://openalex.org/W2038012561","https://openalex.org/W2043471584","https://openalex.org/W2044775606","https://openalex.org/W2045645277","https://openalex.org/W2047656869","https://openalex.org/W2049197710","https://openalex.org/W2051615976","https://openalex.org/W2051768616","https://openalex.org/W2054311839","https://openalex.org/W2058132311","https://openalex.org/W2058221907","https://openalex.org/W2059291619","https://openalex.org/W2060584527","https://openalex.org/W2066235893","https://openalex.org/W2067703482","https://openalex.org/W2068602646","https://openalex.org/W2068805529","https://openalex.org/W2070102480","https://openalex.org/W2070658593","https://openalex.org/W2073307618","https://openalex.org/W2078692950","https://openalex.org/W2079052324","https://openalex.org/W2086556990","https://openalex.org/W2089191944","https://openalex.org/W2089460976","https://openalex.org/W2090822981","https://openalex.org/W2091198609","https://openalex.org/W2097648520","https://openalex.org/W2099735644","https://openalex.org/W2102653059","https://openalex.org/W2106362845","https://openalex.org/W2106784617","https://openalex.org/W2109110326","https://openalex.org/W2110544560","https://openalex.org/W2110607490","https://openalex.org/W2113372190","https://openalex.org/W2113983551","https://openalex.org/W2115087258","https://openalex.org/W2117526623","https://openalex.org/W2117568376","https://openalex.org/W2118222623","https://openalex.org/W2122980078","https://openalex.org/W2123880844","https://openalex.org/W2125749182","https://openalex.org/W2126149754","https://openalex.org/W2132517266","https://openalex.org/W2137124525","https://openalex.org/W2137789326","https://openalex.org/W2138481654","https://openalex.org/W2140899494","https://openalex.org/W2142072523","https://openalex.org/W2142519388","https://openalex.org/W2143859645","https://openalex.org/W2144144709","https://openalex.org/W2147449506","https://openalex.org/W2147852085","https://openalex.org/W2150273317","https://openalex.org/W2151554678","https://openalex.org/W2151784208","https://openalex.org/W2152710595","https://openalex.org/W2153916382","https://openalex.org/W2155418451","https://openalex.org/W2156425900","https://openalex.org/W2157989234","https://openalex.org/W2164727176","https://openalex.org/W2165603655","https://openalex.org/W2167746224","https://openalex.org/W2169287089","https://openalex.org/W2170645981","https://openalex.org/W2171280873","https://openalex.org/W2171501215","https://openalex.org/W2172166803","https://openalex.org/W2216717106","https://openalex.org/W3023540311","https://openalex.org/W4297845865"],"related_works":["https://openalex.org/W2744839322","https://openalex.org/W2127987907","https://openalex.org/W6990634955","https://openalex.org/W2808199112","https://openalex.org/W7096100906","https://openalex.org/W2071492316","https://openalex.org/W225301010","https://openalex.org/W1977077086","https://openalex.org/W2108942802","https://openalex.org/W3150797327"],"abstract_inverted_index":{"Network":[0],"models":[1],"pervade":[2],"modern":[3],"biology.":[4],"From":[5],"ecosystems":[6],"down":[7],"to":[8,32,61,65,113,130],"molecular":[9],"interactions":[10],"in":[11,145,275],"cells,":[12],"they":[13],"provide":[14],"abstraction":[15],"and":[16,26,64,138,143,193,198,225,255],"explanation":[17,234],"for":[18,36,80,177,186,201,235],"biological":[19,47],"processes.":[20,53],"Thus,":[21],"the":[22,81,87,94,139,209,219],"relation":[23],"between":[24,123],"structure":[25,109],"function":[27],"of":[28,40,83,93,96,154,196,212,218,223,269],"networks":[29,48,63,98],"is":[30,102,111,128,141,162,180,206,259],"central":[31],"any":[33,44],"comprehensive":[34],"attempt":[35],"a":[37,91,150,184,194,202,215,251,262],"theoretical":[38],"understanding":[39],"life.":[41],"Just":[42],"as":[43,121,183],"living":[45],"system,":[46],"are":[49,245],"shaped":[50],"by":[51],"evolutionary":[52,76,89,191],"In":[54,208],"reverse,":[55],"artificial":[56],"evolution":[57,82,95],"can":[58,118],"be":[59,119],"employed":[60],"reconstruct":[62],"study":[66,92],"their":[67,236],"evolution.":[68],"To":[69],"this":[70,148,213],"end,":[71],"I":[72],"have":[73],"implemented":[74],"an":[75,107,233],"algorithm":[77],"specifically":[78],"designed":[79],"network":[84],"models.":[85],"With":[86],"developed":[88],"framework,":[90],"information-processing":[97],"was":[99],"performed.":[100],"It":[101,258],"shown":[103,260],"that":[104,110,116,165,261],"selection":[105],"favours":[106],"organisational":[108],"related":[112],"function,":[114],"such":[115],"computations":[117],"visualised":[120],"transitions":[122],"organisations.":[124],"Furthermore,":[125],"mathematical":[126],"modelling":[127],"applied":[129],"extract":[131],"reaction-kinetic":[132],"constants":[133],"from":[134],"fluorescence":[135],"microscopy":[136],"data,":[137],"model":[140,153,188,204],"presented":[142],"discussed":[144],"detail.":[146],"Using":[147],"approach,":[149],"detailed":[151],"quantitative":[152],"exchange":[155,172],"dynamics":[156],"at":[157],"PML":[158,166,178],"nuclear":[159],"bodies":[160],"(NBs)":[161],"created,":[163],"showing":[164],"NB":[167],"components":[168],"exhibit":[169],"highly":[170],"individual":[171],"kinetics.":[173],"The":[174,240],"FRAP":[175],"data":[176],"NBs":[179],"additionally":[181],"used":[182],"test-case":[185],"automatic":[187],"inference":[189],"using":[190,247],"methods,":[192],"set":[195],"necessary":[197],"sufficient":[199],"criteria":[200],"good":[203],"fit":[205],"revealed.":[207],"last":[210],"part":[211],"thesis,":[214],"stochastic":[216],"\\nanalysis":[217],"genetic":[220],"regulatory":[221,238,243],"system":[222],"DEF-like":[224],"GLO-like":[226],"class":[227],"B":[228],"floral":[229],"homeotic":[230],"genes":[231],"provides":[232],"intricate":[237],"wiring.":[239],"different":[241],"potential":[242],"architectures":[244],"investigated":[246],"Monte":[248],"Carlo":[249],"simulation,":[250],"simplified":[252],"master-equation":[253],"model,":[254],"fixedpoint":[256],"analysis.":[257],"positive":[263],"autoregulatory":[264],"loop":[265],"via":[266],"obligate":[267],"heterodimerisation":[268],"transcription":[270],"factor":[271],"proteins":[272],"reduces":[273],"noise":[274],"cell-fate":[276],"organ":[277],"identity":[278],"decisions.":[279]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
