{"id":"https://openalex.org/W2467795684","doi":"https://doi.org/10.1152/jappl.1989.67.4.1388","title":"Influence of tone on responses to acetylcholine in the rabbit pulmonary vascular bed","display_name":"Influence of tone on responses to acetylcholine in the rabbit pulmonary vascular bed","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W2467795684","doi":"https://doi.org/10.1152/jappl.1989.67.4.1388","mag":"2467795684","pmid":"https://pubmed.ncbi.nlm.nih.gov/2793740"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1989.67.4.1388","doi":"https://doi.org/10.1152/jappl.1989.67.4.1388","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1989.67.4.1388","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031010713","display_name":"Albert L. Hyman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. L. Hyman","raw_affiliation_strings":["Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108535774","display_name":"Philip J. Kadowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. J. Kadowitz","raw_affiliation_strings":["Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":null,"apc_paid":null,"fwci":1.4937,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.84626469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"67","issue":"4","first_page":"1388","last_page":"1394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.6327999830245972,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.6327999830245972,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.1873999983072281,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.06350000202655792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pulmonary-vasculature","display_name":"pulmonary vasculature","score":0.7739999890327454},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pressor-response","display_name":"pressor response","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.843999981880188},{"id":"https://openalex.org/keywords/muscarinic-m1-receptor","display_name":"M1 muscarinic receptor","score":0.8870000243186951},{"id":"https://openalex.org/keywords/m2-muscarinic-receptor","display_name":"M2 muscarinic receptor","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pirenzepine","display_name":"pirenzepine","score":0.8679999709129333},{"id":"https://openalex.org/keywords/meclofenamate","display_name":"meclofenamate","score":0.8619999885559082},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/gallamine","display_name":"gallamine","score":0.8450000286102295},{"id":"https://openalex.org/keywords/vascular-resistance","display_name":"vascular resistance","score":0.5550000071525574},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2778616617","wikidata":"https://www.wikidata.org/wiki/Q419550","display_name":"Pirenzepine","level":4,"score":0.8778204917907715},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.8683298826217651},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.7918411493301392},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.7623289823532104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6085779070854187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5818639993667603},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5779972076416016},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5451974868774414},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.287699818611145},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1378956437110901}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005703","descriptor_name":"Gallamine Triethiodide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005703","descriptor_name":"Gallamine Triethiodide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005703","descriptor_name":"Gallamine Triethiodide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008469","descriptor_name":"Meclofenamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008469","descriptor_name":"Meclofenamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008469","descriptor_name":"Meclofenamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010890","descriptor_name":"Pirenzepine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010890","descriptor_name":"Pirenzepine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010890","descriptor_name":"Pirenzepine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1989.67.4.1388","doi":"https://doi.org/10.1152/jappl.1989.67.4.1388","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1989.67.4.1388","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:2793740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2793740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1227780350","display_name":null,"funder_award_id":"HL-11802","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3034031937","display_name":null,"funder_award_id":"HL 15580","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2271483674","https://openalex.org/W2190217256","https://openalex.org/W2343536438","https://openalex.org/W2138545610","https://openalex.org/W2244929487","https://openalex.org/W2336587347","https://openalex.org/W1996219789","https://openalex.org/W7096979400","https://openalex.org/W7146668384","https://openalex.org/W2043654428"],"abstract_inverted_index":{"Pulmonary":[0],"vascular":[1,51,182],"responses":[2,35,106,119,141,155],"to":[3,36,55,120,142,163],"acetylcholine":[4,24,37,63,121,172],"were":[5,41,107,128],"compared":[6],"under":[7,38,122,201],"resting":[8,18,39,123],"and":[9,47,104,124,184,229],"high":[10,57,86,125,202],"tone":[11,19,87,126,203],"conditions":[12,40,127],"of":[13,23,62,93,116,148,160,212,226,239],"the":[14,76,81,90,94,112,157,161,169,179,224,240,243],"intact-chest":[15],"rabbit.":[16],"Under":[17,85],"conditions,":[20,88,204],"intralobar":[21],"injections":[22],"increased":[25],"lobar":[26,50,65],"arterial":[27,66],"pressure":[28],"in":[29,178],"a":[30,56,72,192,205,209,213,233],"dose-related":[31],"manner.":[32],"The":[33,144,165],"pressor":[34,77,91,103,176],"blocked":[42,97,108,129],"by":[43,98,109,130,191,232],"meclofenamate,":[44],"indomethacin,":[45,101],"atropine,":[46],"pirenzepine.":[48,117],"When":[49],"resistance":[52],"was":[53,96],"raised":[54],"steady":[58],"level,":[59],"low":[60],"doses":[61,70],"decreased":[64],"pressure,":[67],"whereas":[68,102,135],"higher":[69],"elicited":[71],"biphasic":[73,214],"response":[74,95,162,188,207,215,219],"with":[75],"component":[78,92,159,211],"predominating":[79],"at":[80],"highest":[82],"dose":[83,115,147],"studied.":[84],"only":[89],"meclofenamate":[99],"or":[100,111,156,208],"depressor":[105,154,158],"atropine":[110],"600-micrograms/kg":[113],"iv":[114,146],"Pressor":[118],"pirenzepine":[131,149],"(50":[132],"micrograms/kg":[133],"iv),":[134],"gallamine":[136],"had":[137,150],"no":[138,151],"effect":[139,152],"on":[140,153,223],"acetylcholine.":[143,164],"50-micrograms/kg":[145],"present":[166],"data":[167,197],"support":[168],"concept":[170],"that":[171,186,236],"has":[173],"significant":[174],"cyclooxygenase-dependent":[175],"activity":[177],"rabbit":[180],"pulmonary":[181],"bed":[183],"suggest":[185],"this":[187],"is":[189,216,220,230,237],"mediated":[190,231],"muscarinic":[193,234],"M1-type":[194],"receptor.":[195],"These":[196],"also":[198],"show":[199],"that,":[200],"vasodilator":[206,210],"unmasked.":[217],"This":[218],"not":[221],"dependent":[222],"release":[225],"cyclooxygenase":[227],"products":[228],"receptor":[235],"neither":[238],"M1-":[241],"nor":[242],"M2-type.":[244]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-07-22T00:00:00"}
