{"id":"https://openalex.org/W2467782813","doi":"https://doi.org/10.1038/srep28600","title":"iTRAQ-Based Proteomics Screen identifies LIPOCALIN-2 (LCN-2) as a potential biomarker for colonic lateral-spreading tumors","display_name":"iTRAQ-Based Proteomics Screen identifies LIPOCALIN-2 (LCN-2) as a potential biomarker for colonic lateral-spreading tumors","publication_year":2016,"publication_date":"2016-06-24","ids":{"openalex":"https://openalex.org/W2467782813","doi":"https://doi.org/10.1038/srep28600","mag":"2467782813","pmid":"https://pubmed.ncbi.nlm.nih.gov/27339395"},"language":"en","primary_location":{"id":"doi:10.1038/srep28600","doi":"https://doi.org/10.1038/srep28600","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep28600","pdf_url":"https://www.nature.com/articles/srep28600.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep28600.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071939690","display_name":"Xianfei Wang","orcid":"https://orcid.org/0000-0003-3669-6866","observed_orcids":["https://orcid.org/0000-0003-3669-6866"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianfei Wang","raw_affiliation_strings":["Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China","Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China","institution_ids":["https://openalex.org/I4210108565"]},{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100382831","display_name":"Aimin Li","orcid":"https://orcid.org/0000-0001-9459-5540","observed_orcids":["https://orcid.org/0000-0001-9459-5540","https://orcid.org/0009-0005-4067-4223","https://orcid.org/0009-0009-9768-9177"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aimin Li","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yubin Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yubin Guo","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yadong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yadong Wang","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102955346","display_name":"Xinhua Zhao","orcid":"https://orcid.org/0000-0003-0772-8240","observed_orcids":["https://orcid.org/0000-0003-0772-8240"]},"institutions":[{"id":"https://openalex.org/I4210095398","display_name":"Mianyang Central Hospital","ror":"https://ror.org/00s528j33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095398"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinhua Zhao","raw_affiliation_strings":["Department of Gastroenterology, Mianyang Central Hospital, Mianyang, China","Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Mianyang Central Hospital, Mianyang, China","institution_ids":["https://openalex.org/I4210095398"]},{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103697254","display_name":"Li Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092654","display_name":"Longgang Central Hospital","ror":"https://ror.org/00j5y7k81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092654"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Xiang","raw_affiliation_strings":["Department of Gastroenterology, Longgang Central Hospital, Shen Zhen, China","Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Longgang Central Hospital, Shen Zhen, China","institution_ids":["https://openalex.org/I4210092654"]},{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041081475","display_name":"Zelong Han","orcid":"https://orcid.org/0000-0003-4217-8117","observed_orcids":["https://orcid.org/0000-0003-4217-8117"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zelong Han","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387859","display_name":"Yue Li","orcid":"https://orcid.org/0000-0003-3747-1482","observed_orcids":["https://orcid.org/0000-0003-3747-1482","https://orcid.org/0000-0002-0843-1118"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Li","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wen Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Xu","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064792206","display_name":"Kangmin Zhuang","orcid":"https://orcid.org/0000-0002-5473-3547","observed_orcids":["https://orcid.org/0000-0002-5473-3547"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kangmin Zhuang","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034913681","display_name":"Qun Yan","orcid":"https://orcid.org/0000-0001-7347-618X","observed_orcids":["https://orcid.org/0000-0001-7347-618X","https://orcid.org/0009-0003-5489-0707"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qun Yan","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009655111","display_name":"Jietao Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jietao Zhong","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003962764","display_name":"Jing Xiong","orcid":"https://orcid.org/0000-0001-7397-1893","observed_orcids":["https://orcid.org/0000-0001-7397-1893"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Xiong","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064119771","display_name":"Side Liu","orcid":"https://orcid.org/0000-0001-8192-988X","observed_orcids":["https://orcid.org/0000-0001-8192-988X"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Side Liu","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.3163,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.5586433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"28600","last_page":"28600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.2754000127315521,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.2754000127315521,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.2070000022649765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.10520000010728836,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laterally-spreading-tumors","display_name":"laterally spreading tumors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9240000247955322},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5870000123977661},{"id":"https://openalex.org/keywords/colonic-neoplasms","display_name":"colonic neoplasms","score":0.8100000023841858},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.7400000095367432},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.7720000147819519},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6439999938011169},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C20299238","wikidata":"https://www.wikidata.org/wiki/Q363928","display_name":"Lipocalin","level":2,"score":0.7842204570770264},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7603616118431091},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.610053539276123},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.5227584838867188},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4765504002571106},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4158240556716919},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.4114454686641693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4112895727157593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3925039768218994},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3696032464504242},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.363484263420105},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26386088132858276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17847704887390137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11684751510620117},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071068","descriptor_name":"Lipocalin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071068","descriptor_name":"Lipocalin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071068","descriptor_name":"Lipocalin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/srep28600","doi":"https://doi.org/10.1038/srep28600","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep28600","pdf_url":"https://www.nature.com/articles/srep28600.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:27339395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27339395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4919649","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4919649","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/srep28600","doi":"https://doi.org/10.1038/srep28600","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep28600","pdf_url":"https://www.nature.com/articles/srep28600.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6654373414","display_name":"\u8840\u7ba1\u7d27\u5f20\u7d20II\u53ca\u8840\u7ba1\u7d27\u5f20\u7d20\uff081-7\uff09\u5bf9\u809d\u810f\u7ebf\u7c92\u4f53\u81ea\u566c\u53caNLRP3\u708e\u75c7\u5c0f\u4f53\u7684\u8c03\u63a7\u4f5c\u7528\uff1aNASH\u7684\u65b0\u673a\u5236","funder_award_id":"81470844","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326242","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2467782813.pdf","grobid_xml":"https://content.openalex.org/works/W2467782813.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W182713024","https://openalex.org/W1588950918","https://openalex.org/W1595533237","https://openalex.org/W1945087438","https://openalex.org/W1964753576","https://openalex.org/W1967142047","https://openalex.org/W1967535690","https://openalex.org/W1969938538","https://openalex.org/W1977009545","https://openalex.org/W1980453995","https://openalex.org/W1982429622","https://openalex.org/W1983084541","https://openalex.org/W1983609115","https://openalex.org/W1988877630","https://openalex.org/W1991910205","https://openalex.org/W2003128698","https://openalex.org/W2009124022","https://openalex.org/W2011689779","https://openalex.org/W2028820493","https://openalex.org/W2033046719","https://openalex.org/W2034141105","https://openalex.org/W2043439690","https://openalex.org/W2043999088","https://openalex.org/W2047245179","https://openalex.org/W2049682385","https://openalex.org/W2053943711","https://openalex.org/W2069706896","https://openalex.org/W2070402245","https://openalex.org/W2070544749","https://openalex.org/W2084728604","https://openalex.org/W2085894544","https://openalex.org/W2094112735","https://openalex.org/W2115295953","https://openalex.org/W2122790967","https://openalex.org/W2144545582"],"related_works":["https://openalex.org/W2374940911","https://openalex.org/W2116355203","https://openalex.org/W2487678993","https://openalex.org/W1980621866","https://openalex.org/W2467782813","https://openalex.org/W2062711653","https://openalex.org/W2554891500","https://openalex.org/W2951279040","https://openalex.org/W4310730543","https://openalex.org/W2052437713"],"abstract_inverted_index":{"The":[0],"improvement":[1],"and":[2,31,82,93,120,152],"implementation":[3],"of":[4,13,26,33,80,95,122],"a":[5,145,155],"colonoscopy":[6],"technique":[7],"has":[8],"led":[9],"to":[10,21,45],"increased":[11],"detection":[12],"laterally":[14],"spreading":[15],"tumors":[16],"(LSTs),":[17],"which":[18],"are":[19],"presumed":[20],"constitute":[22],"an":[23],"aggressive":[24],"type":[25],"colonic":[27],"neoplasm.":[28],"Early":[29],"diagnosis":[30],"treatment":[32],"LSTs":[34,65,77,99],"is":[35],"clinically":[36],"challenging.":[37],"To":[38],"overcome":[39],"this":[40,56],"problem,":[41],"we":[42,58],"employed":[43],"iTRAQ":[44],"identify":[46],"LST-specific":[47],"protein":[48,107,114],"biomarkers":[49],"potentially":[50],"involved":[51],"in":[52,64,98,103,116,159],"LST":[53,123,149],"progression.":[54],"In":[55],"study,":[57],"identified":[59],"2,001":[60],"differentially":[61],"expressed":[62],"proteins":[63,97],"using":[66],"iTRAQ-based":[67],"proteomics":[68],"technology.":[69],"Lipocalin-2":[70],"(LCN-2)":[71],"was":[72,100,109],"the":[73,117],"most":[74],"up-regulated":[75],"protein.":[76],"expression":[78],"levels":[79],"LCN-2":[81,106,143],"matrix":[83],"metallopeptidase-9":[84],"(MMP-9)":[85],"showed":[86],"positive":[87],"correlation":[88],"with":[89,112],"worse":[90],"pathological":[91],"grading,":[92],"up-regulation":[94,115],"these":[96],"also":[101],"reflected":[102],"serum.":[104],"Furthermore,":[105],"overexpression":[108],"positively":[110],"correlated":[111],"MMP-9":[113],"tumor":[118],"tissue":[119],"serum":[121],"patients":[124],"(former":[125],"rs":[126,133],"=":[127,130,134,137],"0.631,":[128],"P":[129,136],"0.000;":[131],"latter":[132],"0.815,":[135],"0.000).":[138],"Our":[139],"results":[140],"suggest":[141],"that":[142],"constitutes":[144],"potential":[146],"biomarker":[147],"for":[148],"disease":[150],"progression":[151],"might":[153],"be":[154],"novel":[156],"therapeutic":[157],"target":[158],"LSTs.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}