{"id":"https://openalex.org/W2467734720","doi":null,"title":"[Value of fluoride therapy in osteoporosis].","display_name":"[Value of fluoride therapy in osteoporosis].","publication_year":1997,"publication_date":"1997-10-20","ids":{"openalex":"https://openalex.org/W2467734720","mag":"2467734720","pmid":"https://pubmed.ncbi.nlm.nih.gov/9445832"},"language":"de","primary_location":{"id":"pmid:9445832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9445832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fortschritte der Medizin","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113785403","display_name":"Ringe Jd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210155030","display_name":"Klinikum Leverkusen","ror":"https://ror.org/05mt2wq31","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155030"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J D Ringe","raw_affiliation_strings":["Medizinische Klinik 4, Klinikum Leverkusen, Akademisches Lehrkrankenhaus, Universit\u00e4t zu K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik 4, Klinikum Leverkusen, Akademisches Lehrkrankenhaus, Universit\u00e4t zu K\u00f6ln","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210155030"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113785403"],"corresponding_institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210155030"],"apc_list":null,"apc_paid":null,"fwci":0.4832,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.73751516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"115","issue":"29","first_page":"30","last_page":"2, 34, 36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11969","display_name":"Fluoride Effects and Removal","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoride-treatment","display_name":"fluoride therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sodium-fluoride","display_name":"sodium fluoride","score":0.8420000076293945},{"id":"https://openalex.org/keywords/sodium-monofluorophosphate","display_name":"sodium monofluorophosphate","score":0.9810000061988831},{"id":"https://openalex.org/keywords/osteoblast-activation","display_name":"osteoblast activation","score":0.890999972820282},{"id":"https://openalex.org/keywords/vertebral-fractures","display_name":"vertebral fractures","score":0.8579999804496765},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.828000009059906},{"id":"https://openalex.org/keywords/corticosteroid-induced-osteoporosis","display_name":"corticosteroid-induced osteoporosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bone-mass","display_name":"bone mass","score":0.5770000219345093},{"id":"https://openalex.org/keywords/bone-quality","display_name":"bone quality","score":0.6909999847412109},{"id":"https://openalex.org/keywords/fracture-risk","display_name":"fracture risk","score":0.6700000166893005},{"id":"https://openalex.org/keywords/calcium-and-vitamin-d-supplementation","display_name":"calcium and vitamin D supplementation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2780828025","wikidata":"https://www.wikidata.org/wiki/Q44793182","display_name":"Fluoride","level":2,"score":0.9462774991989136},{"id":"https://openalex.org/C2779234887","wikidata":"https://www.wikidata.org/wiki/Q407520","display_name":"Sodium fluoride","level":3,"score":0.8218947649002075},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7947064638137817},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6592779159545898},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.5617274045944214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46555668115615845},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43239572644233704},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.42838215827941895},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38911959528923035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35350948572158813},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.329873263835907},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.1876392364501953}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005459","descriptor_name":"Fluorides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005598","descriptor_name":"Fractures, Spontaneous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016103","descriptor_name":"Spinal Fractures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9445832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9445832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fortschritte der Medizin","raw_type":"English Abstract"},{"id":"mag:2467734720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9445832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2118065332","https://openalex.org/W2416220204","https://openalex.org/W2492994897","https://openalex.org/W2419199220","https://openalex.org/W2024702117","https://openalex.org/W2411533318","https://openalex.org/W2010835819","https://openalex.org/W2067761103","https://openalex.org/W1970171252","https://openalex.org/W2018344668"],"abstract_inverted_index":{"Fluoride":[0],"salts":[1],"are":[2],"the":[3,9,12,17,24,69,75,102,106,118,121,146,167,171,175,179],"currently":[4],"most":[5],"effective":[6],"stimulators":[7],"of":[8,19,74,105,116,120,138,170],"osteoblasts.":[10],"Since":[11],"therapeutic":[13,46,147],"effect":[14],"depends":[15],"on":[16],"concentration":[18],"fluoride":[20,28,40,57,64],"ions":[21,58],"achieved":[22],"in":[23,27,68,85,92,135,166,178],"plasma,":[25],"differences":[26],"content":[29],"and":[30,88,110,152,160,173],"bioavailability":[31],"must":[32],"be":[33,51],"taken":[34],"into":[35],"account":[36],"when":[37],"using":[38],"sodium":[39,42],"or":[41],"monofluorophosphate.":[43],"The":[44,60],"optimal":[45],"range":[47],"is":[48,65,95,125,128,145],"assumed":[49],"to":[50,53,141],"10":[52],"20":[54],"mg":[55],"bioavailable":[56],"daily.":[59],"classical":[61],"indication":[62],"for":[63],"manifest":[66],"osteoporosis":[67],"elderly":[70],"woman":[71],"with":[72,100,155,158],"fractures":[73],"vertebrae.":[76],"Available":[77],"data,":[78],"however,":[79],"suggest":[80],"that":[81],"its":[82],"early":[83],"use":[84],"both":[86],"men":[87],"women,":[89],"as":[90],"also":[91],"corticoid-induced":[93],"osteoporosis,":[94],"justified.":[96],"Under":[97],"long-term":[98],"treatment":[99],"fluoride,":[101,117],"bone":[103],"mass":[104],"vertebrae":[107],"increases":[108],"dose-dependently":[109],"linearly.":[111],"At":[112],"very":[113],"high":[114],"doses":[115],"quality":[119],"newly":[122],"formed":[123],"bone-which":[124],"often":[126],"excessive":[127],"presumably":[129],"initially":[130],"inadequate.":[131],"A":[132],"moderate":[133],"increase":[134],"bony":[136],"substance":[137],"about":[139],"4":[140],"6%":[142],"a":[143],"year":[144],"objective.":[148],"Regular":[149],"physical":[150],"exercise":[151],"gymnastics,":[153],"together":[154],"requirement-related":[156],"supplementation":[157],"calcium":[159],"vitamin":[161],"D":[162],"ensures":[163],"an":[164],"improvement":[165],"mechanical":[168],"stability":[169],"bone,":[172],"thus":[174],"desired":[176],"reduction":[177],"fracture":[180],"risk.":[181]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
