{"id":"https://openalex.org/W2467705547","doi":"https://doi.org/10.2485/jhtb.25.288","title":"Is Bone Mineral Density Associated with Estrogen Receptor a in Chinese Men? A Pilot Study","display_name":"Is Bone Mineral Density Associated with Estrogen Receptor a in Chinese Men? A Pilot Study","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2467705547","doi":"https://doi.org/10.2485/jhtb.25.288","mag":"2467705547"},"language":"en","primary_location":{"id":"doi:10.2485/jhtb.25.288","doi":"https://doi.org/10.2485/jhtb.25.288","is_oa":true,"landing_page_url":"https://doi.org/10.2485/jhtb.25.288","pdf_url":"https://www.jstage.jst.go.jp/article/jhtb/25/3/25_288/_pdf","source":{"id":"https://openalex.org/S39874079","display_name":"Journal of Hard Tissue Biology","issn_l":"1341-7649","issn":["1341-7649","1880-828X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4376882122","host_organization_name":"Japanese Society of Hard Tissue Research and Technology","host_organization_lineage":["https://openalex.org/P4376882122"],"host_organization_lineage_names":["Japanese Society of Hard Tissue Research and Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hard Tissue Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jhtb/25/3/25_288/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039081905","display_name":"Yu Lin","orcid":"https://orcid.org/0000-0001-6579-484X","observed_orcids":["https://orcid.org/0000-0001-6579-484X"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]},{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210121071","display_name":"Fuzhou Second Hospital","ror":"https://ror.org/02t4nzq07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121071"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Lin","raw_affiliation_strings":["Fujian Academy of Integrative Medicine (Fujian University of Traditional Chinese Medicine)","Joint Surgery Department, the Second Hospital of Fuzhou Affiliated to Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Academy of Integrative Medicine (Fujian University of Traditional Chinese Medicine)","institution_ids":["https://openalex.org/I118783713"]},{"raw_affiliation_string":"Joint Surgery Department, the Second Hospital of Fuzhou Affiliated to Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210121071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437653","display_name":"Yiyuan Zhang","orcid":"https://orcid.org/0000-0003-0792-8015","observed_orcids":["https://orcid.org/0000-0003-0792-8015"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210121071","display_name":"Fuzhou Second Hospital","ror":"https://ror.org/02t4nzq07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121071"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiyuan Zhang","raw_affiliation_strings":["Joint Surgery Department, the Second Hospital of Fuzhou Affiliated to Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Surgery Department, the Second Hospital of Fuzhou Affiliated to Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210121071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068060931","display_name":"Yunmei Huang","orcid":"https://orcid.org/0009-0002-1570-7095","observed_orcids":["https://orcid.org/0009-0002-1570-7095"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunmei Huang","raw_affiliation_strings":["Fujian Academy of Integrative Medicine (Fujian University of Traditional Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Academy of Integrative Medicine (Fujian University of Traditional Chinese Medicine)","institution_ids":["https://openalex.org/I118783713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019984855","display_name":"Wulian Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210121071","display_name":"Fuzhou Second Hospital","ror":"https://ror.org/02t4nzq07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121071"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wulian Wang","raw_affiliation_strings":["Joint Surgery Department, the Second Hospital of Fuzhou Affiliated to Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Surgery Department, the Second Hospital of Fuzhou Affiliated to Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210121071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103001555","display_name":"Eryou Feng","orcid":"https://orcid.org/0000-0002-9586-0227","observed_orcids":["https://orcid.org/0000-0002-9586-0227"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210121071","display_name":"Fuzhou Second Hospital","ror":"https://ror.org/02t4nzq07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121071"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Eryou Feng","raw_affiliation_strings":["Joint Surgery Department, the Second Hospital of Fuzhou Affiliated to Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Surgery Department, the Second Hospital of Fuzhou Affiliated to Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210121071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100771532","display_name":"Yanping Lin","orcid":"https://orcid.org/0000-0002-3376-1856","observed_orcids":["https://orcid.org/0000-0002-3376-1856"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]},{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210121071","display_name":"Fuzhou Second Hospital","ror":"https://ror.org/02t4nzq07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121071"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanping Lin","raw_affiliation_strings":["Fujian Academy of Integrative Medicine (Fujian University of Traditional Chinese Medicine)","Joint Surgery Department, the Second Hospital of Fuzhou Affiliated to Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Academy of Integrative Medicine (Fujian University of Traditional Chinese Medicine)","institution_ids":["https://openalex.org/I118783713"]},{"raw_affiliation_string":"Joint Surgery Department, the Second Hospital of Fuzhou Affiliated to Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210121071"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"3","first_page":"288","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9980000257492065},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.7940000295639038},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8420000076293945},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.5640000104904175},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":0.703000009059906},{"id":"https://openalex.org/keywords/femoral-neck","display_name":"femoral neck","score":0.6830000281333923},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.6039999723434448},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8050000071525574},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.972000002861023},{"id":"https://openalex.org/keywords/tracp-5b","display_name":"TRACP-5b","score":0.7630000114440918},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.7824803590774536},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7571436762809753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.747003436088562},{"id":"https://openalex.org/C2775854910","wikidata":"https://www.wikidata.org/wiki/Q4844892","display_name":"Femoral neck","level":3,"score":0.631236732006073},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.5915462970733643},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.577424168586731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5468428134918213},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.46788400411605835},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.46317771077156067},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4405505955219269},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28658008575439453},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.17254826426506042},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.13237264752388},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1189073920249939},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2485/jhtb.25.288","doi":"https://doi.org/10.2485/jhtb.25.288","is_oa":true,"landing_page_url":"https://doi.org/10.2485/jhtb.25.288","pdf_url":"https://www.jstage.jst.go.jp/article/jhtb/25/3/25_288/_pdf","source":{"id":"https://openalex.org/S39874079","display_name":"Journal of Hard Tissue Biology","issn_l":"1341-7649","issn":["1341-7649","1880-828X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4376882122","host_organization_name":"Japanese Society of Hard Tissue Research and Technology","host_organization_lineage":["https://openalex.org/P4376882122"],"host_organization_lineage_names":["Japanese Society of Hard Tissue Research and Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hard Tissue Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2485/jhtb.25.288","doi":"https://doi.org/10.2485/jhtb.25.288","is_oa":true,"landing_page_url":"https://doi.org/10.2485/jhtb.25.288","pdf_url":"https://www.jstage.jst.go.jp/article/jhtb/25/3/25_288/_pdf","source":{"id":"https://openalex.org/S39874079","display_name":"Journal of Hard Tissue Biology","issn_l":"1341-7649","issn":["1341-7649","1880-828X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4376882122","host_organization_name":"Japanese Society of Hard Tissue Research and Technology","host_organization_lineage":["https://openalex.org/P4376882122"],"host_organization_lineage_names":["Japanese Society of Hard Tissue Research and Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hard Tissue Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5778627525","display_name":null,"funder_award_id":"81302986","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2467705547.pdf","grobid_xml":"https://content.openalex.org/works/W2467705547.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1523220153","https://openalex.org/W1541149029","https://openalex.org/W1565369626","https://openalex.org/W1722531939","https://openalex.org/W1913993984","https://openalex.org/W1923465237","https://openalex.org/W1941816602","https://openalex.org/W1987124529","https://openalex.org/W2001894928","https://openalex.org/W2005309784","https://openalex.org/W2036125852","https://openalex.org/W2036823680","https://openalex.org/W2050332373","https://openalex.org/W2058695789","https://openalex.org/W2070228338","https://openalex.org/W2078814719","https://openalex.org/W2081379880","https://openalex.org/W2096754770","https://openalex.org/W2096761587","https://openalex.org/W2100530025","https://openalex.org/W2103062902","https://openalex.org/W2110752622","https://openalex.org/W2117025246","https://openalex.org/W2139776494","https://openalex.org/W2145305345","https://openalex.org/W2145801998","https://openalex.org/W2168242208","https://openalex.org/W2265344823","https://openalex.org/W2401731965","https://openalex.org/W2417358192","https://openalex.org/W2468924201"],"related_works":["https://openalex.org/W2377873775","https://openalex.org/W2044054235","https://openalex.org/W2078981627","https://openalex.org/W1016677248","https://openalex.org/W2000324791","https://openalex.org/W2361623081","https://openalex.org/W2082215747","https://openalex.org/W2170866858","https://openalex.org/W2388397332","https://openalex.org/W2367679101"],"abstract_inverted_index":{"This":[0],"study":[1],"aimed":[2],"to":[3,73,145],"assess":[4,74],"the":[5,129],"associations":[6,223],"of":[7,46,80,131],"telomerase":[8],"reverse":[9],"transcriptase":[10],"(TERT)":[11],"and":[12,24,35,59,68,77,85,99,107,110,119,142,166,176,192,198,201,209,226],"estrogen":[13],"receptor-\u03b1":[14],"(ER\u03b1)":[15],"levels":[16,45,112],"with":[17,116,149,156,172,196,213,218],"bone":[18,27,90],"mineral":[19],"density":[20],"in":[21,89,128,215,221],"Chinese":[22,216],"men":[23,225],"women.":[25,227],"Cancellous":[26],"samples":[28],"were":[29,62,71,113,154,187],"obtained":[30,155],"from":[31],"femoral":[32],"neck":[33],"fracture":[34],"osteoarthritis":[36],"patients.":[37],"BMD":[38,47,117,120,132,150,157,174,177,190,193,214],"was":[39],"evaluated":[40],"by":[41,64],"X-ray":[42],"absorptiometry.":[43],"Serum":[44],"markers,":[48],"including":[49],"osteocalcin":[50],"(BGP),":[51],"tartrate-resistant":[52],"acid":[53],"phosphatase":[54],"5b":[55],"(TRACP5b),":[56],"estradiol":[57],"(E2)":[58],"testosterone":[60],"(T),":[61],"measured":[63],"ELISA.":[65],"Real-time":[66],"PCR":[67],"Western":[69],"blot":[70],"used":[72],"hTERT,":[75],"ER\u03b1,":[76],"human":[78],"protection":[79],"telomeres":[81],"1":[82],"(hPot1)":[83],"mRNA":[84,101,109],"protein":[86,111,144,168,200],"levels,":[87,102],"respectively,":[88],"specimens.":[91],"Age,":[92],"E2,":[93,140],"T,":[94,141],"TRACP5b,":[95],"BGP,":[96],"TNF-\u03b1,":[97],"NF-kB":[98],"Pot1":[100],"as":[103,105,122],"well":[104],"TERT":[106,143,164,197,208],"ER\u03b1":[108,167,199,210],"all":[114],"correlated":[115],"(FN)":[118,175,194],"(AP)":[121,178,191],"single":[123],"variables,":[124],"except":[125,159],"for":[126,160,189],"sex":[127],"case":[130],"(FN).":[133],"Multiple":[134],"regression":[135],"analysis":[136],"revealed":[137],"sex,":[138,163],"age,":[139],"be":[146],"significantly":[147],"associated":[148,212],"(AP);":[151],"similar":[152],"findings":[153,205],"(FN),":[158],"sex.":[161],"Interestingly,":[162],"mRNA,":[165],"showed":[169],"significant":[170],"correlations":[171,195],"both":[173],"(all":[179],"P<0.01)":[180],"after":[181],"collinearity":[182],"diagnostics.":[183],"Importantly,":[184],"gender":[185],"differences":[186,219],"observed":[188,220],"gene":[202],"levels.":[203],"These":[204],"indicate":[206],"that":[207],"are":[211],"individuals,":[217],"these":[222],"between":[224]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-07-22T00:00:00"}