{"id":"https://openalex.org/W2467478866","doi":"https://doi.org/10.1152/ajpheart.1985.248.6.h783","title":"Cell biology and protein composition of cardiac gap junctions","display_name":"Cell biology and protein composition of cardiac gap junctions","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W2467478866","doi":"https://doi.org/10.1152/ajpheart.1985.248.6.h783","mag":"2467478866","pmid":"https://pubmed.ncbi.nlm.nih.gov/2408491"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1985.248.6.h783","doi":"https://doi.org/10.1152/ajpheart.1985.248.6.h783","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1985.248.6.h783","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029927773","display_name":"Chellakere K. Manjunath","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. K. Manjunath","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110082068","display_name":"Ernest W. Page","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Page","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2102,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.79798908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"248","issue":"6","first_page":"H783","last_page":"H791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-gap-junctions","display_name":"cardiac gap junctions","score":0.996999979019165},{"id":"https://openalex.org/keywords/connexons","display_name":"connexons","score":0.9909999966621399},{"id":"https://openalex.org/keywords/connexin-47","display_name":"connexin 47","score":0.7329999804496765},{"id":"https://openalex.org/keywords/serine-protease-cleavage","display_name":"serine protease cleavage","score":0.8119999766349792},{"id":"https://openalex.org/keywords/rabbit-heart","display_name":"rabbit heart","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C201685922","wikidata":"https://www.wikidata.org/wiki/Q420047","display_name":"Connexon","level":5,"score":0.8864908814430237},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.8165658712387085},{"id":"https://openalex.org/C118322738","wikidata":"https://www.wikidata.org/wiki/Q7452050","display_name":"Septate junctions","level":4,"score":0.6072731614112854},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5211963057518005},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5190413594245911},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4699181616306305},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.45051780343055725},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.4407734274864197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41829216480255127},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4127649962902069},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.4117574989795685},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3434997797012329},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3384479284286499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3280627727508545},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2511078715324402},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.13605892658233643},{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.11726701259613037},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1985.248.6.h783","doi":"https://doi.org/10.1152/ajpheart.1985.248.6.h783","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1985.248.6.h783","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:2408491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2408491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1392648815","display_name":null,"funder_award_id":"HL 10503","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5754078603","display_name":null,"funder_award_id":"HL 20592","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2026275114","https://openalex.org/W2218614576","https://openalex.org/W2043477921","https://openalex.org/W2417404361","https://openalex.org/W2109971610","https://openalex.org/W2421424807","https://openalex.org/W1103612","https://openalex.org/W1796266773","https://openalex.org/W2149805770","https://openalex.org/W2424805025"],"abstract_inverted_index":{"The":[0,113],"gap":[1,46,83,88,144,155],"junctions":[2,47,84,89],"that":[3,70,102],"electrically":[4],"couple":[5],"mammalian":[6,81],"myocardial":[7],"cells":[8,152],"have":[9],"high":[10,132],"(12,000-17,000/micron2)surface":[11],"densities":[12],"of":[13,40,80,93,148,162],"channel-containing":[14],"elements":[15],"(connexons),":[16],"undulating":[17],"surfaces,":[18],"and":[19,56,110],"approximately":[20],"hexagonally":[21],"arrayed":[22],"connexons":[23,149],"disposed":[24],"in":[25,90,108,153],"small":[26],"domains":[27],"rotated":[28],"with":[29,37],"respect":[30],"to":[31,119,140],"one":[32],"another.":[33],"Optical":[34],"diffraction":[35],"combined":[36],"image":[38],"processing":[39],"negatively":[41],"stained":[42],"isolated":[43],"rabbit":[44],"heart":[45],"shows":[48],"six":[49,72],"protein":[50,63,160],"subunits":[51,79,161],"surrounding":[52],"the":[53,71,91,154,163],"cell-to-cell":[54],"channel":[55],"suggestive":[57],"(but":[58],"not":[59],"conclusive)":[60],"evidence":[61],"for":[62],"connections":[64],"between":[65,159],"connexons.":[66,164],"Biochemical":[67],"studies":[68],"indicate":[69],"identical":[73],"relative":[74],"molecular":[75],"weight":[76],"(Mr)":[77],"47,000":[78],"cardiac":[82],"differ":[85],"from":[86,127,150],"liver":[87],"presence":[92],"a":[94],"covalently":[95],"bound":[96],"Mr":[97],"17,500":[98],"cytoplasmic":[99,114],"surface":[100,115],"component":[101,116],"can":[103],"be":[104],"visualized":[105],"electron":[106],"microscopically":[107],"thin-sectioned":[109],"freeze-etched":[111],"hearts.":[112],"is":[117],"susceptible":[118],"cleavage":[120],"by":[121,131],"an":[122],"alkaline":[123],"serine":[124],"protease":[125],"released":[126],"mast":[128],"cell":[129],"granules":[130],"ionic":[133],"strength":[134],"solutions":[135],"(0.6":[136],"M":[137],"KI)":[138],"used":[139],"extract":[141],"myofibrils":[142],"during":[143],"junction":[145],"purification.":[146],"Interlocking":[147],"coupled":[151],"involves":[156],"hydrogen":[157],"bonding":[158]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
