{"id":"https://openalex.org/W2467365263","doi":"https://doi.org/10.1111/trf.13687","title":"Where do Trypanosoma cruzi go? The distribution of parasites in blood components from fractionated infected whole blood","display_name":"Where do Trypanosoma cruzi go? The distribution of parasites in blood components from fractionated infected whole blood","publication_year":2016,"publication_date":"2016-06-19","ids":{"openalex":"https://openalex.org/W2467365263","doi":"https://doi.org/10.1111/trf.13687","mag":"2467365263","pmid":"https://pubmed.ncbi.nlm.nih.gov/27321651"},"language":"en","primary_location":{"id":"doi:10.1111/trf.13687","doi":"https://doi.org/10.1111/trf.13687","is_oa":false,"landing_page_url":"https://doi.org/10.1111/trf.13687","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048448598","display_name":"Beatriz Cancino\u2010Faure","orcid":"https://orcid.org/0000-0001-6472-2924","observed_orcids":["https://orcid.org/0000-0001-6472-2924"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Cancino\u2010Faure","raw_affiliation_strings":["Laboratori de Parasitologia, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farm\u00e0cia Universitat de Barcelona Barcelona Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratori de Parasitologia, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farm\u00e0cia Universitat de Barcelona Barcelona Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080047931","display_name":"Roser Fisa","orcid":"https://orcid.org/0000-0003-0699-7609","observed_orcids":["https://orcid.org/0000-0003-0699-7609"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Roser Fisa","raw_affiliation_strings":["Laboratori de Parasitologia, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farm\u00e0cia Universitat de Barcelona Barcelona Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratori de Parasitologia, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farm\u00e0cia Universitat de Barcelona Barcelona Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035234507","display_name":"Cristina Riera","orcid":"https://orcid.org/0000-0002-3522-5598","observed_orcids":["https://orcid.org/0000-0002-3522-5598"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Riera","raw_affiliation_strings":["Laboratori de Parasitologia, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farm\u00e0cia Universitat de Barcelona Barcelona Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratori de Parasitologia, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farm\u00e0cia Universitat de Barcelona Barcelona Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048062634","display_name":"Enrique Girona\u2010Llobera","orcid":"https://orcid.org/0000-0003-4035-3460","observed_orcids":["https://orcid.org/0000-0003-4035-3460"]},"institutions":[{"id":"https://openalex.org/I4210138061","display_name":"Research Institute of Health Sciences","ror":"https://ror.org/03nmxrr49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210138061"]},{"id":"https://openalex.org/I4210151792","display_name":"Banc de Sang i Teixits","ror":"https://ror.org/053d4n634","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210151792"]},{"id":"https://openalex.org/I50441567","display_name":"Universitat de les Illes Balears","ror":"https://ror.org/03e10x626","country_code":"ES","type":"education","lineage":["https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Enrique Girona\u2010Llobera","raw_affiliation_strings":["Fundaci\u00f3 Banc de Sang i Teixits de las Illes Balears","IUNICS Institut Universitari d' Investigaci\u00f3 en Ci\u00e8ncies de la Salut, Universitat de les Illes Balears Majorca Balearic Islands Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3 Banc de Sang i Teixits de las Illes Balears","institution_ids":["https://openalex.org/I4210151792"]},{"raw_affiliation_string":"IUNICS Institut Universitari d' Investigaci\u00f3 en Ci\u00e8ncies de la Salut, Universitat de les Illes Balears Majorca Balearic Islands Spain","institution_ids":["https://openalex.org/I4210138061","https://openalex.org/I50441567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044363138","display_name":"Teresa Jimen\u00e9z\u2010Marco","orcid":"https://orcid.org/0000-0001-9631-6541","observed_orcids":["https://orcid.org/0000-0001-9631-6541"]},"institutions":[{"id":"https://openalex.org/I4210138061","display_name":"Research Institute of Health Sciences","ror":"https://ror.org/03nmxrr49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210138061"]},{"id":"https://openalex.org/I4210151792","display_name":"Banc de Sang i Teixits","ror":"https://ror.org/053d4n634","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210151792"]},{"id":"https://openalex.org/I50441567","display_name":"Universitat de les Illes Balears","ror":"https://ror.org/03e10x626","country_code":"ES","type":"education","lineage":["https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Teresa Jimenez\u2010Marco","raw_affiliation_strings":["Fundaci\u00f3 Banc de Sang i Teixits de las Illes Balears","IUNICS Institut Universitari d' Investigaci\u00f3 en Ci\u00e8ncies de la Salut, Universitat de les Illes Balears Majorca Balearic Islands Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3 Banc de Sang i Teixits de las Illes Balears","institution_ids":["https://openalex.org/I4210151792"]},{"raw_affiliation_string":"IUNICS Institut Universitari d' Investigaci\u00f3 en Ci\u00e8ncies de la Salut, Universitat de les Illes Balears Majorca Balearic Islands Spain","institution_ids":["https://openalex.org/I4210138061","https://openalex.org/I50441567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080047931"],"corresponding_institution_ids":["https://openalex.org/I71999127"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":0.7837,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.73753255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"56","issue":"9","first_page":"2233","last_page":"2238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1405","display_name":"Management of Technology and Innovation"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":1.0},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/transfusion-transmitted-infections","display_name":"transfusion-transmitted infections","score":0.9330000281333923},{"id":"https://openalex.org/keywords/platelet-concentrates","display_name":"platelet concentrates","score":0.6639999747276306},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/buffy-coat","display_name":"buffy coat","score":0.8849999904632568},{"id":"https://openalex.org/keywords/leukodepletion","display_name":"leukocyte depletion","score":0.9900000095367432},{"id":"https://openalex.org/keywords/parasite-load","display_name":"infection intensity","score":0.8579999804496765},{"id":"https://openalex.org/keywords/triatomine-bugs","display_name":"Chagas disease vectors","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.8363478183746338},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.5674392580986023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5574178695678711},{"id":"https://openalex.org/C112418997","wikidata":"https://www.wikidata.org/wiki/Q649558","display_name":"Chagas disease","level":2,"score":0.5449473261833191},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4491196274757385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.332461953163147},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.2904369831085205},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016913","descriptor_name":"Blood Component Transfusion","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016913","descriptor_name":"Blood Component Transfusion","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D017713","descriptor_name":"Platelet Transfusion","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017713","descriptor_name":"Platelet Transfusion","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D059208","descriptor_name":"Parasite Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/trf.13687","doi":"https://doi.org/10.1111/trf.13687","is_oa":false,"landing_page_url":"https://doi.org/10.1111/trf.13687","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmid:27321651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27321651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4757682858","display_name":null,"funder_award_id":"PI 10/00533","funder_id":"https://openalex.org/F4320338067","funder_display_name":"Institute of Infection and Immunity"},{"id":"https://openalex.org/G6279808587","display_name":null,"funder_award_id":"72130155","funder_id":"https://openalex.org/F4320334812","funder_display_name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"}],"funders":[{"id":"https://openalex.org/F4320334812","display_name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/02ap3w078"},{"id":"https://openalex.org/F4320338067","display_name":"Institute of Infection and Immunity","ror":"https://ror.org/05wdecy17"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1520121206","https://openalex.org/W1563713995","https://openalex.org/W1584164370","https://openalex.org/W1851610228","https://openalex.org/W1859605094","https://openalex.org/W1964446929","https://openalex.org/W1972065659","https://openalex.org/W1975680994","https://openalex.org/W1975918191","https://openalex.org/W2015909500","https://openalex.org/W2058484100","https://openalex.org/W2059624704","https://openalex.org/W2063338129","https://openalex.org/W2068391140","https://openalex.org/W2068794323","https://openalex.org/W2083176001","https://openalex.org/W2086805346","https://openalex.org/W2087448541","https://openalex.org/W2102748706","https://openalex.org/W2109634529","https://openalex.org/W2113655983","https://openalex.org/W2119386841","https://openalex.org/W2121183668","https://openalex.org/W2141928845","https://openalex.org/W2168826823","https://openalex.org/W2169406325","https://openalex.org/W2170706082","https://openalex.org/W2431531238"],"related_works":["https://openalex.org/W1851610228","https://openalex.org/W2086805346","https://openalex.org/W2109634529","https://openalex.org/W7034455787","https://openalex.org/W1530448241","https://openalex.org/W2610319730","https://openalex.org/W7098265342","https://openalex.org/W2063338129","https://openalex.org/W7100332044","https://openalex.org/W4415106091"],"abstract_inverted_index":{"BACKGROUND:":[0],"Platelets":[1],"(PLTs)":[2],"are":[3],"the":[4,18,39,65,126,136,178,192],"blood":[5,22,26,43,59,128],"component":[6,60],"most":[7],"frequently":[8],"involved":[9],"in":[10,17,57,89,108,135,161,182,191,225,229],"Trypanosoma":[11],"cruzi":[12,62,75,222],"transfusion":[13],"transmission":[14],"cases":[15],"reported":[16],"literature,":[19],"although":[20],"whole":[21],"(WB)":[23],"and":[24,98,101,143,166,228],"red":[25],"cells":[27],"(RBCs)":[28],"have":[29],"also":[30],"been":[31],"incriminated.":[32],"However,":[33],"there":[34],"is":[35,200],"little":[36],"knowledge":[37],"of":[38,51,204,236],"parasite":[40,76,106,120,141,152,162,176,187],"distribution":[41],"among":[42,125],"components.":[44,129],"STUDY":[45],"DESIGN":[46],"AND":[47],"METHODS:":[48],"The":[49,73,105,130,185],"aim":[50],"this":[52],"study":[53],"was":[54,78,122,133,189],"to":[55],"investigate":[56],"which":[58,155],"T.":[61,70,74,221],"parasites":[63,116],"concentrate":[64],"most,":[66],"after":[67,99,154],"fractionating":[68],"artificially":[69],"cruzi-infected":[71],"WB.":[72],"load":[77,107],"studied":[79],"by":[80,147,170,195],"a":[81,158,201,233],"specific":[82],"quantitative":[83],"real-time":[84],"polymerase":[85],"chain":[86],"reaction":[87],"(qPCR)":[88],"WB,":[90],"buffy":[91],"coat":[92],"(BC),":[93],"PLT":[94],"concentrates,":[95],"RBCs":[96,144,156,196],"before":[97,145,197],"leukoreduction,":[100],"plasma":[102],"(PL).":[103],"RESULTS:":[104],"WB":[109],"experimentally":[110],"infected":[111],"with":[112,209,232],"1.5":[113],"\u00d7":[114,118,139,150],"10(6)":[115],"(2.78":[117],"10(3)":[119,140,151],"equivalents/mL)":[121,142],"unevenly":[123],"distributed":[124],"separated":[127],"highest":[131,186],"level":[132],"found":[134],"BC":[137],"(6.94":[138],"leukoreduction":[146],"filtration":[148],"(2.51":[149],"equivalents/mL),":[153],"presented":[157],"99.9%":[159],"reduction":[160],"levels.":[163],"Both":[164],"PL":[165],"PLTs,":[167],"partially":[168],"leukoreduced":[169],"centrifugation":[171],"but":[172],"nonfiltered,":[173],"had":[174],"low":[175],"levels,":[177],"lowest":[179],"concentration":[180,188],"being":[181],"PL.":[183],"CONCLUSIONS:":[184],"detected":[190],"BC,":[193],"followed":[194],"leukoreduction.":[198],"There":[199],"notable":[202],"risk":[203],"transfusion-transmitted":[205,220],"Chagas":[206],"disease":[207],"associated":[208],"nonleukoreduced":[210],"RBCs.":[211],"Leukoreduction":[212],"may":[213],"be":[214],"an":[215],"effective":[216],"prevention":[217],"strategy":[218],"for":[219],"infection,":[223],"especially":[224],"endemic":[226],"countries":[227,231],"nonendemic":[230],"high":[234],"rate":[235],"immigration":[237],"from":[238],"Latin":[239],"America.":[240]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}