{"id":"https://openalex.org/W2467341106","doi":null,"title":"Measuring blood perfusion in the brain using arterial spin labelled MRI","display_name":"Measuring blood perfusion in the brain using arterial spin labelled MRI","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2467341106","mag":"2467341106"},"language":"en","primary_location":{"id":"pmh:hdl:10068/905141","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/905141","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063225564","display_name":"Laura M. Parkes","orcid":"https://orcid.org/0000-0001-6488-507X","observed_orcids":["https://orcid.org/0000-0001-6488-507X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Laura M. Parkes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063225564"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-perfusion","display_name":"cerebral perfusion","score":0.7900000214576721},{"id":"https://openalex.org/keywords/perfusion-quantification","display_name":"perfusion quantification","score":0.9459999799728394},{"id":"https://openalex.org/keywords/two-compartment-model","display_name":"two-compartment model","score":0.8240000009536743},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7630000114440918},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7549999952316284},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.796999990940094},{"id":"https://openalex.org/keywords/arteriovenous-malformation","display_name":"arteriovenous malformation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/motor-activation","display_name":"motor activation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/normal-appearing-white-matter","display_name":"normal-appearing white matter","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.9167840480804443},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.6926445960998535},{"id":"https://openalex.org/C154281038","wikidata":"https://www.wikidata.org/wiki/Q629232","display_name":"Cerebral perfusion pressure","level":3,"score":0.5433261394500732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5198400616645813},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46852582693099976},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.44623878598213196},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.42413851618766785},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3756621778011322},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3703114688396454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.343290776014328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1303042471408844},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07238543033599854},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/905141","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/905141","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10102088","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10102088/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:2467341106","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/402080","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4255196931","https://openalex.org/W2106072096","https://openalex.org/W3158888707","https://openalex.org/W2036725789","https://openalex.org/W1591277533","https://openalex.org/W2736777746","https://openalex.org/W2080966182","https://openalex.org/W3029074101","https://openalex.org/W2039241269","https://openalex.org/W7133284007"],"abstract_inverted_index":{"Perfusion":[0,135],"is":[1,47,74,87,105,121,137,144,164,195,209],"a":[2,29,48,169,179,182,198],"fundamental":[3],"biological":[4],"function,":[5],"giving":[6,28,197],"an":[7,127],"indication":[8],"of":[9,15,25,32,44,51,56,67,133,155,178,189,201,220,246,266],"tissue":[10,141],"metabolism,":[11],"through":[12],"the":[13,42,68,78,91,94,116,176,247,250,281],"rate":[14],"blood":[16,95],"supply.":[17],"Changes":[18],"in":[19,90,111,216,225,237,257,263,273,280],"perfusion":[20,36,57,119,151,162,167,192,199,208,221,253,261,278],"accompany":[21],"almost":[22],"all":[23,131],"forms":[24],"brain":[26,53,92,96,207],"disease":[27],"wide":[30],"range":[31],"potential":[33],"applications":[34],"for":[35,109,130,139],"imaging.":[37],"Arterial":[38],"spin":[39],"labelled":[40],"MRI,":[41],"subject":[43,171],"this":[45,86],"thesis,":[46],"good":[49],"method":[50],"measuring":[52],"perfusion.":[54,134],"Issues":[55],"quantification,":[58],"i.e.":[59],"accuracy":[60],"and":[61,143,181,232,239,249],"precision":[62],"are":[63,223,255,271],"addressed.":[64],"Current":[65],"models":[66],"perfusing":[69],"system":[70],"assume":[71],"that":[72,85,115,160],"water":[73,99],"freely":[75],"diffusible":[76],"across":[77],"capillary":[79],"wall.":[80],"Several":[81],"published":[82],"values":[83],"show":[84,114],"not":[88],"true":[89],"where":[93],"barrier":[97],"restricts":[98],"passage.":[100],"A":[101,153,184],"corrected":[102],"two-compartment":[103],"model":[104],"presented,":[106],"with":[107,149,193,276],"simplifications":[108],"use":[110],"vivo.":[112],"Simulations":[113],"change":[117,222],"to":[118,146,211,287],"estimation":[120],"large.":[122],"In":[123],"vivo":[124],"modelling":[125],"shows":[126,159],"improved":[128],"fit":[129],"extremes":[132],"reproducibility":[136],"measured":[138],"different":[140,260,264],"volumes":[142],"found":[145,210,272],"compare":[147],"favourably":[148],"other":[150],"techniques.":[152],"study":[154],"thirty-two":[156],"normal":[157,282,288],"volunteers":[158],"inter-subject":[161],"variation":[163],"large,":[165],"but":[166],"within":[168],"single":[170],"remains":[172],"fairly":[173],"stable":[174],"over":[175],"course":[177],"day":[180],"week.":[183],"significant":[185,277],"(p<0.05)":[186],"negative":[187],"correlation":[188],"grey":[190],"matter":[191,285],"age":[194],"reported,":[196],"decrease":[200],"0.5%":[202],"per":[203],"year.":[204],"Female":[205],"whole":[206],"be":[212],"16%":[213],"higher":[214],"than":[215],"males":[217],"(p=0.02).":[218],"Measurements":[219],"made":[224],"stroke,":[226],"arteriovenous":[227],"malformation":[228],"(AVM),":[229],"motor":[230,240],"activation":[231,241],"multiple":[233,274],"sclerosis.":[234],"The":[235],"examples":[236],"stroke":[238],"serve":[242],"as":[243],"important":[244],"validation":[245],"technique":[248],"modelling.":[251],"Gross":[252],"abnormalities":[254],"detected":[256],"AVM":[258],"showing":[259],"characteristics":[262],"regions":[265],"AVM.":[267],"More":[268],"subtle":[269],"changes":[270],"sclerosis,":[275],"increases":[279],"appearing":[283],"white":[284],"compared":[286],"controls.":[289]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-07-22T00:00:00"}